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The map label for this gene is hflK [H]

Identifier: 222110310

GI number: 222110310

Start: 1145098

End: 1146453

Strand: Direct

Name: hflK [H]

Synonym: Dtpsy_1097

Alternate gene names: 222110310

Gene position: 1145098-1146453 (Clockwise)

Preceding gene: 222110309

Following gene: 222110311

Centisome position: 30.16

GC content: 61.28

Gene sequence:

>1356_bases
ATGAACCTTCTTAACCGGGCCTCTCGCTGGGCCGTGCTGCCTGAGCGTATTCGGGGAATGTTCAATCTCAACGATCCTCG
TTGGGGCCGTGGGGACGATAAGGGCGAGGGTGGACAGCGCCCTGATTCGGAGCGCCCTTCTCCGGATAACTCACAGCGTC
CACGTGGACGTGACCAGAATCCTTCGGGACAGCCACCGGACCTGGATGAGTTGTGGCGTGATCTGAACCGCAAGCTGGGT
GGGTTGTTTGGCGGCGGCGGGTCGCGTGGCCCCGCTTCTGGTGGCGGCAATGGTGGTTTCCAGCCAGACATGAAGAACGC
GGGAGTTGGCGTGGGATTGATCGCCGCCATAGCGGTGCTGATCTGGCTGGGCACTGGCTTTTTCATCGTGCAAGAAGGCC
AGCAAGCGGTGATCACCCAGTTCGGCAAGTACAAGAGCACGGTCAACGCCGGCTTCAATTGGCGTCTGCCTTACCCCATT
CAGCGCCATGAACTGGTGTTCGTGACCCAGATCCGGTCCGCTGATGTGGGGCGGGATAGCGTCATCAAGAGCACGGGACT
GCGTGAGTCCGCCATGCTGACCGAAGACGAGAACATCGTCGAAATCAAGTTCGCAGTGCAATATCGTTTGAATGACGCGC
GTGCGTGGCTGTTCGAGAGCCGCAACCCGGCCGAAGCCGTGGTTCAGGCGGCAGAGACGGCGGTGCGCGAAGTCGTGGGC
AAAATGCGCATGGATACCGCCTTGGCGGAAGAGCGGGACCAGATTGCTCCGCGCGTGCGCAACCTGATGCAGACCATCTT
GGACCGATACAAGGTCGGCGTGGAAGTCGTTGGCATCAACCTGCAGCAAGGGGGGGTGCGCCCTCCTGAGCAAGTACAGG
CGGCTTTTGATGACGTGCTCAAGGCGGGCCAGGAGCGGGAGCGCGCTAAGAACGAAGCCCAGGCTTATGCCAATGATGTG
GTTCCGCGTGCCACGGGTACGGCGTCCCGCTTGATCGAGGAGGCGGCAGCCTACAAGGCGCGCATCGTGGCGCAGGCGCA
GGGTGACACACAGCGCTTCAGCGCCGTCCTTGCTGAATACCAGAAGGCGCCGCAGGTGACGCGAGACCGCATGTATCTGG
AGAGCATGCAGCAGATTTACGGCAATGTGACCAAGGTACTGGTGGAGTCGCGGCAAGGATCCAACTTGCTGTACCTGCCG
TTGGACAAGATCATGCAGAGCGTTTCACAGCAGACTTCGGCGGCTGCGGCGACCGATACGCCGCCAGCGACAGTCCCTCC
TGCCGCGACCTCTCAATTTCCCGGCGATTCTCGGTTGCGTGATGCCAACCGTTCGCGCGAACGTGAGTCCCGATAG

Upstream 100 bases:

>100_bases
AGGCATGCCCCCTGAGACGGCGGCTGAATTGAAGGGCGAGTGGGACTGATTGGGCACAATGCTGGTGTTCTATTGCTATT
GAGAGTACGAGAATTCGCGC

Downstream 100 bases:

>100_bases
GAGAGCCGTGTGAACAGAATCGGATTTATCGCATCGACAGTTCTGCTGTTGCTGGCATTGCTCAGCTCGATGGTGTTCGT
CGTCGACCAACGCCAGTTTG

Product: hflk protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNLLNRASRWAVLPERIRGMFNLNDPRWGRGDDKGEGGQRPDSERPSPDNSQRPRGRDQNPSGQPPDLDELWRDLNRKLG
GLFGGGGSRGPASGGGNGGFQPDMKNAGVGVGLIAAIAVLIWLGTGFFIVQEGQQAVITQFGKYKSTVNAGFNWRLPYPI
QRHELVFVTQIRSADVGRDSVIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPAEAVVQAAETAVREVVG
KMRMDTALAEERDQIAPRVRNLMQTILDRYKVGVEVVGINLQQGGVRPPEQVQAAFDDVLKAGQERERAKNEAQAYANDV
VPRATGTASRLIEEAAAYKARIVAQAQGDTQRFSAVLAEYQKAPQVTRDRMYLESMQQIYGNVTKVLVESRQGSNLLYLP
LDKIMQSVSQQTSAAAATDTPPATVPPAATSQFPGDSRLRDANRSRERESR

Sequences:

>Translated_451_residues
MNLLNRASRWAVLPERIRGMFNLNDPRWGRGDDKGEGGQRPDSERPSPDNSQRPRGRDQNPSGQPPDLDELWRDLNRKLG
GLFGGGGSRGPASGGGNGGFQPDMKNAGVGVGLIAAIAVLIWLGTGFFIVQEGQQAVITQFGKYKSTVNAGFNWRLPYPI
QRHELVFVTQIRSADVGRDSVIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPAEAVVQAAETAVREVVG
KMRMDTALAEERDQIAPRVRNLMQTILDRYKVGVEVVGINLQQGGVRPPEQVQAAFDDVLKAGQERERAKNEAQAYANDV
VPRATGTASRLIEEAAAYKARIVAQAQGDTQRFSAVLAEYQKAPQVTRDRMYLESMQQIYGNVTKVLVESRQGSNLLYLP
LDKIMQSVSQQTSAAAATDTPPATVPPAATSQFPGDSRLRDANRSRERESR
>Mature_451_residues
MNLLNRASRWAVLPERIRGMFNLNDPRWGRGDDKGEGGQRPDSERPSPDNSQRPRGRDQNPSGQPPDLDELWRDLNRKLG
GLFGGGGSRGPASGGGNGGFQPDMKNAGVGVGLIAAIAVLIWLGTGFFIVQEGQQAVITQFGKYKSTVNAGFNWRLPYPI
QRHELVFVTQIRSADVGRDSVIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPAEAVVQAAETAVREVVG
KMRMDTALAEERDQIAPRVRNLMQTILDRYKVGVEVVGINLQQGGVRPPEQVQAAFDDVLKAGQERERAKNEAQAYANDV
VPRATGTASRLIEEAAAYKARIVAQAQGDTQRFSAVLAEYQKAPQVTRDRMYLESMQQIYGNVTKVLVESRQGSNLLYLP
LDKIMQSVSQQTSAAAATDTPPATVPPAATSQFPGDSRLRDANRSRERESR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=282, Percent_Identity=36.8794326241135, Blast_Score=214, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 49660; Mature: 49660

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLNRASRWAVLPERIRGMFNLNDPRWGRGDDKGEGGQRPDSERPSPDNSQRPRGRDQN
CCHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSGQPPDLDELWRDLNRKLGGLFGGGGSRGPASGGGNGGFQPDMKNAGVGVGLIAAIAVL
CCCCCCCHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
IWLGTGFFIVQEGQQAVITQFGKYKSTVNAGFNWRLPYPIQRHELVFVTQIRSADVGRDS
HHHCCCEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCCCHHH
VIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPAEAVVQAAETAVREVVG
HHHHCCCCHHHCCCCCCCEEEEEEEEEEEECHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
KMRMDTALAEERDQIAPRVRNLMQTILDRYKVGVEVVGINLQQGGVRPPEQVQAAFDDVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHH
KAGQERERAKNEAQAYANDVVPRATGTASRLIEEAAAYKARIVAQAQGDTQRFSAVLAEY
HCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QKAPQVTRDRMYLESMQQIYGNVTKVLVESRQGSNLLYLPLDKIMQSVSQQTSAAAATDT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCC
PPATVPPAATSQFPGDSRLRDANRSRERESR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLLNRASRWAVLPERIRGMFNLNDPRWGRGDDKGEGGQRPDSERPSPDNSQRPRGRDQN
CCHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSGQPPDLDELWRDLNRKLGGLFGGGGSRGPASGGGNGGFQPDMKNAGVGVGLIAAIAVL
CCCCCCCHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
IWLGTGFFIVQEGQQAVITQFGKYKSTVNAGFNWRLPYPIQRHELVFVTQIRSADVGRDS
HHHCCCEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCCCHHH
VIKSTGLRESAMLTEDENIVEIKFAVQYRLNDARAWLFESRNPAEAVVQAAETAVREVVG
HHHHCCCCHHHCCCCCCCEEEEEEEEEEEECHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
KMRMDTALAEERDQIAPRVRNLMQTILDRYKVGVEVVGINLQQGGVRPPEQVQAAFDDVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHH
KAGQERERAKNEAQAYANDVVPRATGTASRLIEEAAAYKARIVAQAQGDTQRFSAVLAEY
HCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QKAPQVTRDRMYLESMQQIYGNVTKVLVESRQGSNLLYLPLDKIMQSVSQQTSAAAATDT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCC
PPATVPPAATSQFPGDSRLRDANRSRERESR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]