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The map label for this gene is ndk [H]

Identifier: 222110299

GI number: 222110299

Start: 1134154

End: 1134579

Strand: Direct

Name: ndk [H]

Synonym: Dtpsy_1086

Alternate gene names: 222110299

Gene position: 1134154-1134579 (Clockwise)

Preceding gene: 222110298

Following gene: 222110300

Centisome position: 29.87

GC content: 62.21

Gene sequence:

>426_bases
ATGGCTATCGAACGCACCCTTTCCATCATCAAGCCGGACGCAGTTGCCAAGAACGTGATCGGTCAGATCTATGCGCGCTT
TGAAGCCGCGGGCCTGAAGATTGTCGCTGCGCGCATGATCCACCTGTCGCGCGCCGAAGCCGAGCAGTTCTACGCAGTGC
ACAAGGAGCGCCCCTTCTTCAAGGATCTGGTGGACTTCATGATTTCCGGCCCCGTGATGGTGCAGGCCCTGGAGGGTGAG
AACGCCGTCCTGAAGAACCGCGAACTCATGGGCGCGACCGACCCCAAGAAGGCGGCGCCCGGCACGATCCGCGCCGACTT
CGCGGACAGCATCGACGCCAATGCGGTGCACGGCTCCGACGCTGCCGAAACCGCCCAGGTGGAAGTGGCCTTCTTCTTCC
CTGGCCTGAACATCTACTCGCGCTAA

Upstream 100 bases:

>100_bases
GGGCCGCGCCGCGGCGGCCGTTAGGGGATTGGCGTAAAGCTAAAATTGATGGTTTGCCTTCAGGGCAAAAATACCGCAAC
ACCTCACTAGGAAAATCAAC

Downstream 100 bases:

>100_bases
TGCAGTGGCTCCGCGTGCCGGGCGGTCCTGGTTTGGCCGCCCCCGCGCGGATGCGCTATGTGGGCGTGGACATCCGTGAA
CGTTATGACCACGAACCTTC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAARMIHLSRAEAEQFYAVHKERPFFKDLVDFMISGPVMVQALEGE
NAVLKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSDAAETAQVEVAFFFPGLNIYSR

Sequences:

>Translated_141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAARMIHLSRAEAEQFYAVHKERPFFKDLVDFMISGPVMVQALEGE
NAVLKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSDAAETAQVEVAFFFPGLNIYSR
>Mature_140_residues
AIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAARMIHLSRAEAEQFYAVHKERPFFKDLVDFMISGPVMVQALEGEN
AVLKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSDAAETAQVEVAFFFPGLNIYSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=43.1818181818182, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI38045913, Length=131, Percent_Identity=40.4580152671756, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI4557797, Length=131, Percent_Identity=40.4580152671756, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=39.2307692307692, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=35.8208955223881, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=35.8208955223881, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=35.7664233576642, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI30023828, Length=143, Percent_Identity=34.965034965035, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI148839372, Length=134, Percent_Identity=35.0746268656716, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=34.5588235294118, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=61.6541353383459, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=130, Percent_Identity=43.8461538461538, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=41.5384615384615, Blast_Score=123, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45549037, Length=130, Percent_Identity=44.6153846153846, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=32.5925925925926, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24645457, Length=136, Percent_Identity=30.8823529411765, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15382; Mature: 15251

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAARMIHLSRAEAEQFYAVHKERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KDLVDFMISGPVMVQALEGENAVLKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AAETAQVEVAFFFPGLNIYSR
CCCCEEEEEEEEECCCCCCCC
>Mature Secondary Structure 
AIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAARMIHLSRAEAEQFYAVHKERPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KDLVDFMISGPVMVQALEGENAVLKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AAETAQVEVAFFFPGLNIYSR
CCCCEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA