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The map label for this gene is yedX [C]

Identifier: 222110256

GI number: 222110256

Start: 1084851

End: 1085201

Strand: Direct

Name: yedX [C]

Synonym: Dtpsy_1043

Alternate gene names: 222110256

Gene position: 1084851-1085201 (Clockwise)

Preceding gene: 222110255

Following gene: 222110258

Centisome position: 28.57

GC content: 66.1

Gene sequence:

>351_bases
ATGGGCCTCAGCACCCACGTTCTTGACACCATGCACGGTTGCCCCGCGGCGGGCATGGTGGTGGCGCTGTATGCCACGCA
GGGTGACCAGGCCACGCTGGTCAAGCGCCTGGTGCTCAACCCCGATGGGCGCACCGATGCGCCGCTGTTCGACAACGCCA
GCCTGCGCACCGGCACCTACCGGCTGACGTTTGATGTGGGGGCGTATTTCAAGGCGAAAGGCGTGATGCTGCCCGAGCCC
TCATTCCTGGACCGCGTGAGCCTGGACTTCGGCATCGCCCACGCCGACCAGCATTACCACGTGCCGCTGCTGGTCAGCCC
CTGGAGCTATTCCACCTACCGCGGGTCCTGA

Upstream 100 bases:

>100_bases
GTTCGTAGGGACGGGGAGCGTATCACTTGCCTGCCCATTCGCCAGCGGATTCCTCATCACCATCGGCGGGCCGCGGCTTG
CCATTGCAGGAGACTTCACC

Downstream 100 bases:

>100_bases
TGCTGCAAGCCCGCGCTGTGTGCCGCGCGGCGCAGGGCAAGGCGGAGCTAATTCCTTGCGAGTCGCGCATGCCTGCTTTG
GGCGGGCTGCGGCGGTGCAG

Product: hydroxyisourate hydrolase

Products: NA

Alternate protein names: HIU hydrolase; HIUHase [H]

Number of amino acids: Translated: 116; Mature: 115

Protein sequence:

>116_residues
MGLSTHVLDTMHGCPAAGMVVALYATQGDQATLVKRLVLNPDGRTDAPLFDNASLRTGTYRLTFDVGAYFKAKGVMLPEP
SFLDRVSLDFGIAHADQHYHVPLLVSPWSYSTYRGS

Sequences:

>Translated_116_residues
MGLSTHVLDTMHGCPAAGMVVALYATQGDQATLVKRLVLNPDGRTDAPLFDNASLRTGTYRLTFDVGAYFKAKGVMLPEP
SFLDRVSLDFGIAHADQHYHVPLLVSPWSYSTYRGS
>Mature_115_residues
GLSTHVLDTMHGCPAAGMVVALYATQGDQATLVKRLVLNPDGRTDAPLFDNASLRTGTYRLTFDVGAYFKAKGVMLPEPS
FLDRVSLDFGIAHADQHYHVPLLVSPWSYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=114, Percent_Identity=37.719298245614, Blast_Score=78, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115532922, Length=116, Percent_Identity=44.8275862068966, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115532920, Length=116, Percent_Identity=44.8275862068966, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115534555, Length=116, Percent_Identity=41.3793103448276, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 12660; Mature: 12528

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00768 TRANSTHYRETIN_1 ; PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLSTHVLDTMHGCPAAGMVVALYATQGDQATLVKRLVLNPDGRTDAPLFDNASLRTGTY
CCCCCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
RLTFDVGAYFKAKGVMLPEPSFLDRVSLDFGIAHADQHYHVPLLVSPWSYSTYRGS
EEEEECCCEEEECCEECCCCCCCCEEECCCCEEECCCCEEEEEEECCCCCCEECCC
>Mature Secondary Structure 
GLSTHVLDTMHGCPAAGMVVALYATQGDQATLVKRLVLNPDGRTDAPLFDNASLRTGTY
CCCCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
RLTFDVGAYFKAKGVMLPEPSFLDRVSLDFGIAHADQHYHVPLLVSPWSYSTYRGS
EEEEECCCEEEECCEECCCCCCCCEEECCCCEEECCCCEEEEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]