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The map label for this gene is echA8 [H]

Identifier: 222110209

GI number: 222110209

Start: 1036495

End: 1037298

Strand: Direct

Name: echA8 [H]

Synonym: Dtpsy_0995

Alternate gene names: 222110209

Gene position: 1036495-1037298 (Clockwise)

Preceding gene: 222110208

Following gene: 222110210

Centisome position: 27.3

GC content: 69.53

Gene sequence:

>804_bases
ATGGCCGCAGGAGAGGCCGCCGGCCGCGGCGTGGTGCGCGTGACGCTGCGCCACGAGGGCCGGCTCAACGCCATGTCGCG
CGCCATGTGGCGCCAGTTGCGCACGGTGTTCCAGGACATCCAGCGCAGCGATGGCGTGCGCTGCGTGCTCATCGAGGGGG
CAGGGGAGGCGTTCTGTGCGGGGGGGGATATTTCCGAGTACCCCGCCTTTCGCTTCGACCCCGCGCAGCTGCGCGACTTC
CACGAGAGCGATGTCTGGGGCGGGCTGGCGGCCATGCTGGACTGCGACGTACCCATCGTCGCGCGCATCGCAGGCGCCTG
CATGGGCGCGGGCGTGGAGATCGCCAGCTGCTGCGACATCCGCATTGCCGCTGCCGGCGCGCGTTTCGGCGCGCCCATCG
CCAAGCTGGGCTTTCCGATGGCGCCGCGCGAGGCTGCCTTGGTGGCGGGCGCCGTGGGCGACGTGACGGCGCGCCAGATG
CTGTTGGAGGCGGCCACCTTCAGCGCCGCCGAGATGGCGCAGCGGGGCTTTCTGAGCCGCGTGGTCGACACCGAGCAGCT
GGATGCGCAAGCCCTGGGCACGGCGCTGCGCATCGCAGCCTTGGCGCCCGGTGCGGCCCGGCTCAACAAGCAGACCTTGC
GCGCTATACGGAAGAATGTGCCGCTAGCGCCCGACCAGCAAGCGCAAGCAGCTTCTGATTTGATAGCAAATAACGCACTG
GCCGACCCCTACGCCTATGCCGACAGCGCCGAACACCGCGAGGGTATCAACGCCTTCCTGGCCAAGCGCGCTCCCGTTTT
CTGA

Upstream 100 bases:

>100_bases
CTGGAGTGATGTAGCCCCCCACTGCGGCGCCCCTCCAGTGGCGCCGCCTCCACCCCCACGAAGAGAGTCCGATCGCATGC
CAGGTGAAGTTGTCGCGGCC

Downstream 100 bases:

>100_bases
ATCCTTTGTGTGTGCACCACCATGAGCTCCTCCTCCCAGAACCTGTTTTCCGCGCTGCGCGCCGCCTTTCCTGCTGACCT
GGACCAGACCGCCGTCGAGG

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MAAGEAAGRGVVRVTLRHEGRLNAMSRAMWRQLRTVFQDIQRSDGVRCVLIEGAGEAFCAGGDISEYPAFRFDPAQLRDF
HESDVWGGLAAMLDCDVPIVARIAGACMGAGVEIASCCDIRIAAAGARFGAPIAKLGFPMAPREAALVAGAVGDVTARQM
LLEAATFSAAEMAQRGFLSRVVDTEQLDAQALGTALRIAALAPGAARLNKQTLRAIRKNVPLAPDQQAQAASDLIANNAL
ADPYAYADSAEHREGINAFLAKRAPVF

Sequences:

>Translated_267_residues
MAAGEAAGRGVVRVTLRHEGRLNAMSRAMWRQLRTVFQDIQRSDGVRCVLIEGAGEAFCAGGDISEYPAFRFDPAQLRDF
HESDVWGGLAAMLDCDVPIVARIAGACMGAGVEIASCCDIRIAAAGARFGAPIAKLGFPMAPREAALVAGAVGDVTARQM
LLEAATFSAAEMAQRGFLSRVVDTEQLDAQALGTALRIAALAPGAARLNKQTLRAIRKNVPLAPDQQAQAASDLIANNAL
ADPYAYADSAEHREGINAFLAKRAPVF
>Mature_266_residues
AAGEAAGRGVVRVTLRHEGRLNAMSRAMWRQLRTVFQDIQRSDGVRCVLIEGAGEAFCAGGDISEYPAFRFDPAQLRDFH
ESDVWGGLAAMLDCDVPIVARIAGACMGAGVEIASCCDIRIAAAGARFGAPIAKLGFPMAPREAALVAGAVGDVTARQML
LEAATFSAAEMAQRGFLSRVVDTEQLDAQALGTALRIAALAPGAARLNKQTLRAIRKNVPLAPDQQAQAASDLIANNALA
DPYAYADSAEHREGINAFLAKRAPVF

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=27.8625954198473, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI70995211, Length=227, Percent_Identity=27.7533039647577, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI194097323, Length=254, Percent_Identity=24.4094488188976, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1787660, Length=260, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87082183, Length=252, Percent_Identity=26.1904761904762, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=28.7937743190661, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788597, Length=267, Percent_Identity=26.9662921348315, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=25.2830188679245, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17534483, Length=224, Percent_Identity=27.6785714285714, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=260, Percent_Identity=26.1538461538462, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=272, Percent_Identity=26.4705882352941, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=257, Percent_Identity=25.2918287937743, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=212, Percent_Identity=23.1132075471698, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=210, Percent_Identity=25.2380952380952, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24653139, Length=279, Percent_Identity=28.3154121863799, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920382, Length=214, Percent_Identity=25.7009345794392, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20129971, Length=265, Percent_Identity=26.7924528301887, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24653477, Length=265, Percent_Identity=26.7924528301887, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28152; Mature: 28020

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAGEAAGRGVVRVTLRHEGRLNAMSRAMWRQLRTVFQDIQRSDGVRCVLIEGAGEAFCA
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEC
GGDISEYPAFRFDPAQLRDFHESDVWGGLAAMLDCDVPIVARIAGACMGAGVEIASCCDI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCE
RIAAAGARFGAPIAKLGFPMAPREAALVAGAVGDVTARQMLLEAATFSAAEMAQRGFLSR
EEEECCCHHCCCHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVDTEQLDAQALGTALRIAALAPGAARLNKQTLRAIRKNVPLAPDQQAQAASDLIANNAL
HHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
ADPYAYADSAEHREGINAFLAKRAPVF
CCCHHHCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAGEAAGRGVVRVTLRHEGRLNAMSRAMWRQLRTVFQDIQRSDGVRCVLIEGAGEAFCA
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEC
GGDISEYPAFRFDPAQLRDFHESDVWGGLAAMLDCDVPIVARIAGACMGAGVEIASCCDI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCE
RIAAAGARFGAPIAKLGFPMAPREAALVAGAVGDVTARQMLLEAATFSAAEMAQRGFLSR
EEEECCCHHCCCHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVDTEQLDAQALGTALRIAALAPGAARLNKQTLRAIRKNVPLAPDQQAQAASDLIANNAL
HHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
ADPYAYADSAEHREGINAFLAKRAPVF
CCCHHHCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]