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The map label for this gene is ilvD1 [H]

Identifier: 222110202

GI number: 222110202

Start: 1028920

End: 1030776

Strand: Direct

Name: ilvD1 [H]

Synonym: Dtpsy_0988

Alternate gene names: 222110202

Gene position: 1028920-1030776 (Clockwise)

Preceding gene: 222110200

Following gene: 222110203

Centisome position: 27.1

GC content: 67.96

Gene sequence:

>1857_bases
ATGCCCGCATACCGTTCCAAGACCTCCACCGCCGGCCGCAACATGGCAGGGGCCCGCTCCCTGTGGCGCGCCACCGGCAT
GAAAGACGCCGATTTCTCCAAGCCCATCATCGCGGTGGTCAACTCGTTCACCCAGTTCGTGCCCGGCCATGTGCATCTGA
AAGACCTGGGCCAGCTCGTGGCGCGCGAGATCGAGGCCGCCGGCGGCGTGGCCAAGGAATTCAACACCATCGCCGTGGAT
GACGGCATCGCCATGGGCCACGACGGCATGCTGTATTCGCTGCCCAGCCGCGACATCATTGCCGACAGCGTGGAATACAT
GGTGAACGCGCACTGTGCCGACGCCATGGTCTGCATCAGCAACTGCGACAAGATCACCCCCGGCATGCTCATGGCCGCCA
TGCGGCTGAACATTCCGGTGATCTTCGTCTCCGGCGGCCCCATGGAGGCCGGCAAGGTGCAGCAGACCGTGCCCGGCACC
AGCACCATCCAGATCAAGAAGCTGGACCTGATCGACGCCATGGTGATGGCCGCCGACGACAAGGTGAGCGACGCCGACCT
GGCCGAGGCCGAGCGCAATGCCTGCCCCACCTGCGGCTCCTGCTCGGGCATGTTCACCGCCAACTCCATGAACTGCCTGA
CCGAGGCGCTGGGCCTGTCCCTGCCCGGCAACGGCACCGTGGTGGCCACGCACGCCGACCGCGAGCAGCTGTTCAAGCGC
GCGGGCCGGCGCATCGTGGAGCTGGCGCGCCAGCACTACGAACAGGGCGACGAGCGCATCCTGCCGCGCTCGGTCGGCTT
CAAGGCCTTCGAGAACGCGATGACGCTGGACATCGCCATGGGCGGCTCCACCAATACCATCCTGCACCTGCTGGCGATCG
CGCAGGAGGCCGGCATCGACTTCAGCATGGCCGACATCGACCGCCTGTCGCGCAGCGTGCCGCAGCTGTGCAAGGTGGCA
CCCAACACCGACAAGTACCACATCGAGGACGTGCACCGCGCCGGCGGCATCTTCGCCATCCTGGGCGAGCTGGAGCGTGC
GGGCAAGCTGCACACCGACGTGCCCACCATCCACGCACCCACACTGGGCGAGGCGCTGGCGCAGTGGGATGTGACGCGCA
CGCAGGACGAAGCCGTCCAGACGTTCTACAAGGCCGGCCCCGGCGGCGTGCCCACGCAGGTCGCCTTCAGCCAGAGCGTG
CGCTGGCCCAGCCTGGACCTGGACCGCGCCGCGGGCTGTATCCGCTCCGCGGAGCACGCCTTCAGCAAGGAAGGCGGCCT
GGCGGTGCTCACCGGCAACATCGCCAAGGACGGCTGCGTGGTCAAGACCGCGGGCGTTCATGAATCCATCCTGGTCTTCG
AAGGCCCGGCGCATGTGGTCGAAAGCCAGGACGAGGCGGTGGAGAACATCCTGGCCGACAAAGTGAAGGCCGGCGACGTG
GTGGTGGTGCGCTACGAGGGCCCCAAGGGCGGCCCCGGCATGCAGGAAATGCTCTACCCCACGAGCTACATCAAATCCAA
GGGCCTGGGCAAGGCCTGCGCGCTGCTGACCGACGGGCGCTTCTCGGGCGGCACCTCGGGCCTGTCCATCGGCCACTGCT
CGCCCGAGGCGGCAGCCGGCGGCGCGATCGGCCTGGTGCGCGACGGCGACCGCATCCGCATCGACATTCCCAACCGCACC
ATCAACGTACTGGTGAGCGACGAGGAGTTGGCCCAGCGCCGCGCCGAGCAGGACGCCAAGGGCTGGAAGCCCGCCCAGCC
ACGTCCGCGCAAGGTCTCGGCCGCGCTCAAGGCCTATGCCAAGCTCGTGACGTCGGCCGACAAGGGCGCGGTGCGCGACG
TGTCGCTGCTGGACTGA

Upstream 100 bases:

>100_bases
GCCTAGGGCGGGGCTCAAGAGGTTTCCGCTGCGGCGCGCGCAGGCCCCCAAGCGCACGGGCCCATCGACTTTCCTGAGCC
ACTCATCTCCCGCAACCACG

Downstream 100 bases:

>100_bases
CGTGGTGCGGTGCACGCCCATGCCGGGCGTGCGCTCCTGATTTATGAGCTGCTCGCGCTGGATGGAAGCAATTTAGAGGG
GCATTTGAGCTTCAAATGTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MPAYRSKTSTAGRNMAGARSLWRATGMKDADFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVQQTVPGT
STIQIKKLDLIDAMVMAADDKVSDADLAEAERNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGRRIVELARQHYEQGDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFSMADIDRLSRSVPQLCKVA
PNTDKYHIEDVHRAGGIFAILGELERAGKLHTDVPTIHAPTLGEALAQWDVTRTQDEAVQTFYKAGPGGVPTQVAFSQSV
RWPSLDLDRAAGCIRSAEHAFSKEGGLAVLTGNIAKDGCVVKTAGVHESILVFEGPAHVVESQDEAVENILADKVKAGDV
VVVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDRIRIDIPNRT
INVLVSDEELAQRRAEQDAKGWKPAQPRPRKVSAALKAYAKLVTSADKGAVRDVSLLD

Sequences:

>Translated_618_residues
MPAYRSKTSTAGRNMAGARSLWRATGMKDADFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVQQTVPGT
STIQIKKLDLIDAMVMAADDKVSDADLAEAERNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGRRIVELARQHYEQGDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFSMADIDRLSRSVPQLCKVA
PNTDKYHIEDVHRAGGIFAILGELERAGKLHTDVPTIHAPTLGEALAQWDVTRTQDEAVQTFYKAGPGGVPTQVAFSQSV
RWPSLDLDRAAGCIRSAEHAFSKEGGLAVLTGNIAKDGCVVKTAGVHESILVFEGPAHVVESQDEAVENILADKVKAGDV
VVVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDRIRIDIPNRT
INVLVSDEELAQRRAEQDAKGWKPAQPRPRKVSAALKAYAKLVTSADKGAVRDVSLLD
>Mature_617_residues
PAYRSKTSTAGRNMAGARSLWRATGMKDADFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVQQTVPGTS
TIQIKKLDLIDAMVMAADDKVSDADLAEAERNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKRA
GRRIVELARQHYEQGDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFSMADIDRLSRSVPQLCKVAP
NTDKYHIEDVHRAGGIFAILGELERAGKLHTDVPTIHAPTLGEALAQWDVTRTQDEAVQTFYKAGPGGVPTQVAFSQSVR
WPSLDLDRAAGCIRSAEHAFSKEGGLAVLTGNIAKDGCVVKTAGVHESILVFEGPAHVVESQDEAVENILADKVKAGDVV
VVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDRIRIDIPNRTI
NVLVSDEELAQRRAEQDAKGWKPAQPRPRKVSAALKAYAKLVTSADKGAVRDVSLLD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=621, Percent_Identity=73.9130434782609, Blast_Score=936, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=543, Percent_Identity=30.939226519337, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI2367371, Length=514, Percent_Identity=32.6848249027237, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786464, Length=563, Percent_Identity=31.6163410301954, Blast_Score=188, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=38.1967213114754, Blast_Score=354, Evalue=2e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65676; Mature: 65545

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSKTSTAGRNMAGARSLWRATGMKDADFSKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVQQTVPGTSTIQIKKLDLIDAMVMAADD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCC
KVSDADLAEAERNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGRRIVELARQHYEQGDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGID
HHHHHHHHHHHHHHCCCCEECCHHCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHCCC
FSMADIDRLSRSVPQLCKVAPNTDKYHIEDVHRAGGIFAILGELERAGKLHTDVPTIHAP
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLGEALAQWDVTRTQDEAVQTFYKAGPGGVPTQVAFSQSVRWPSLDLDRAAGCIRSAEHA
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHH
FSKEGGLAVLTGNIAKDGCVVKTAGVHESILVFEGPAHVVESQDEAVENILADKVKAGDV
HCCCCCEEEEECCCCCCCEEEEECCCCCEEEEEECCHHHHCCHHHHHHHHHHHHCCCCCE
VVVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRDGDRIRIDIPNRTINVLVSDEELAQRRAEQDAKGWKPAQPRPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KLVTSADKGAVRDVSLLD
HHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAYRSKTSTAGRNMAGARSLWRATGMKDADFSKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVQQTVPGTSTIQIKKLDLIDAMVMAADD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCC
KVSDADLAEAERNACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGRRIVELARQHYEQGDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGID
HHHHHHHHHHHHHHCCCCEECCHHCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHCCC
FSMADIDRLSRSVPQLCKVAPNTDKYHIEDVHRAGGIFAILGELERAGKLHTDVPTIHAP
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLGEALAQWDVTRTQDEAVQTFYKAGPGGVPTQVAFSQSVRWPSLDLDRAAGCIRSAEHA
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHH
FSKEGGLAVLTGNIAKDGCVVKTAGVHESILVFEGPAHVVESQDEAVENILADKVKAGDV
HCCCCCEEEEECCCCCCCEEEEECCCCCEEEEEECCHHHHCCHHHHHHHHHHHHCCCCCE
VVVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRDGDRIRIDIPNRTINVLVSDEELAQRRAEQDAKGWKPAQPRPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KLVTSADKGAVRDVSLLD
HHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA