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The map label for this gene is acsA [H]

Identifier: 222110197

GI number: 222110197

Start: 1023018

End: 1025015

Strand: Direct

Name: acsA [H]

Synonym: Dtpsy_0983

Alternate gene names: 222110197

Gene position: 1023018-1025015 (Clockwise)

Preceding gene: 222110189

Following gene: 222110198

Centisome position: 26.95

GC content: 66.72

Gene sequence:

>1998_bases
ATGAGTGCATCGTCCAATGCCATCGAATCCGTATTGGTGGAGAACCGCGTCTTCCCGCCTGCCGATAGCGTGGTGAAGGC
GGCCCGCGTGTCGGGCATGGCCGGCTACGAGGCCCTGTGCGCCGAAGCCAACAAGGATCCCGAGGGCTTCTGGGCGCGCC
TGGCGCGCGAGCACCTGCAATGGACCAAGCCGTTCACGCAGACGCTGGACGAGTCCAAGGCGCCGTTCTACCAGTGGTTT
GCCGACGGCGAGCTCAACGCCAGTGCCAACTGCCTGGACAAGCACATGGGCACGCCGGTCGAGAACAAGGCCGCCATCCT
CTTCGAGGCCGACGACGGCACCGTCACCCAGGTCACTTACCGGCAACTGCTGGAGCGCGTGAGCCAGTTCGCCAATGCCC
TGAAGGCGCACGGCGTGCAGCAGGGCGACCGCGTGCTCATCTACATGCCGATGGGCGTGGAAGGCGTGGTGGCCATGCAG
GCCTGCGCGCGCATCGGCGCCACGCACAGCGTGGTGTTCGGCGGTTTCTCTGCCAAGGCGCTGAACGAGCGCATCATCGA
TGCGGGTGCCGTGGCGGTGATCACGGCCAACTACCAATTGCGCGGCGGCAAGGAACTGCCCCTGAAGGCCATCGTGGACG
AGGGTCTGTCCATGGGCGGCTGCGACAGCATCAAGAATGTCTTCGTATACCAGCGCACGGCCACGGCCTGCGACATGGTG
GCGGGGCGTGACAAGACCTTCTCCGAGATCCTGGCCGGGCAGAGCACCGAATGCCCACCCACGCCCGTGGGCGCGGAGCA
TCCGCTGTTCATCCTCTACACCAGCGGCTCCACGGGCAAGCCCAAGGGCGTGCAGCACAGCACCGGCGGCTACCTGCTGT
GGGCCAAGGTGACGATGGAGTGGACCTTCGACATTCGCCCCGACGACGTGTTCTGGTGCACGGCCGATATCGGCTGGATC
ACGGGCCACACCTACGTGGCCTACGGCCCGCTGGCTGCGGGTGCCACGCAGGTGGTGTTCGAGGGCGTGCCCACGTACCC
CAACGCCGGGCGCTTCTGGCAGATGATCGAGCGCCACAAGGTCACGGTGTTCTACACGGCGCCCACCGCCATCCGCTCGC
TCATCAAGGCGGCCGACTCCGACGAGAGCGTGCACCCCAAGAACTGGGATCTGTCGAGCCTGCGCATCCTGGGCAGCGTG
GGCGAGCCCATCAACCCCGAGGCCTGGATGTGGTACTACCGCCATGTGGGCGGCGAGCGCTGCCCCATCGTGGACACGTT
CTGGCAGACCGAAAACGGCGGCCACGTCATCACCCCGCTGCCGGGTGCTACACCGCTCGTGCCGGGTTCGTGCACCTTGC
CGCTGCCGGGCATCCAGGCTGCCATCGTCGATGAAACCGGCAAAGACCTGCCCAACGGCGCGGGCGGCATGCTCGTGATC
AAGCGGCCCTGGCCCTCGATGATCCGCACCATCTGGGGCGACCCCGAGCGCTTCAAGAAAAGCTACTTCCCCGAAGAGCT
GGGGGGCACCACCTACCTGGCCGGCGACGGCGCCGTGCGCAGTGCCGACCGTGGCTACTTCCGCATCACGGGCCGCATCG
ACGACGTGCTGAACGTGTCGGGCCACCGCATGGGCACGATGGAGATCGAGTCCGCCCTGGTCGCCAAGACGGACCTCGTG
GCTGAGGCCGCCGTGGTGGGCCGTCCCGACGACCTGACGGGCGAGGCGATTTGCGCCTTCGTGGTGCTCAAGCGCTCGCG
CCCCACGGGCGAGGAGGCCAAGCAGATCGCCACCGAACTGCGCAACTGGGTCGCCAAGGAGATCGGCCCCATCGCCAAGC
CCAAGGACATCCGCTTCGGTGACAACCTGCCCAAGACCCGCAGCGGCAAGATCATGCGCCGCCTGCTGCGCTCGATCGCC
AAGGGCGAACCCATCACCCAGGACACCAGCACCCTGGAAAACCCCGCAATCCTGGATCAGTTGGCGCAGTCCAACTGA

Upstream 100 bases:

>100_bases
GCGCTGGAGCGCTGCCGTATGCTGTGGCGCTCCGTCAGTGGCCTGTAAGTACCAGGGCTGAAAGTACCACCCAAAATTCT
TAGCTTCAGGAGACAAACCC

Downstream 100 bases:

>100_bases
TGCAGGAGGCGCCGCAAGGCGCCGGCGCGCAGCGCTTGCGGGGTTGGACGGCACTCATATCTGCGCAGCAGATGTGATGT
GCTGGCAAAAACATTGGATC

Product: acetate/CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MSASSNAIESVLVENRVFPPADSVVKAARVSGMAGYEALCAEANKDPEGFWARLAREHLQWTKPFTQTLDESKAPFYQWF
ADGELNASANCLDKHMGTPVENKAAILFEADDGTVTQVTYRQLLERVSQFANALKAHGVQQGDRVLIYMPMGVEGVVAMQ
ACARIGATHSVVFGGFSAKALNERIIDAGAVAVITANYQLRGGKELPLKAIVDEGLSMGGCDSIKNVFVYQRTATACDMV
AGRDKTFSEILAGQSTECPPTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKVTMEWTFDIRPDDVFWCTADIGWI
TGHTYVAYGPLAAGATQVVFEGVPTYPNAGRFWQMIERHKVTVFYTAPTAIRSLIKAADSDESVHPKNWDLSSLRILGSV
GEPINPEAWMWYYRHVGGERCPIVDTFWQTENGGHVITPLPGATPLVPGSCTLPLPGIQAAIVDETGKDLPNGAGGMLVI
KRPWPSMIRTIWGDPERFKKSYFPEELGGTTYLAGDGAVRSADRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLV
AEAAVVGRPDDLTGEAICAFVVLKRSRPTGEEAKQIATELRNWVAKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIA
KGEPITQDTSTLENPAILDQLAQSN

Sequences:

>Translated_665_residues
MSASSNAIESVLVENRVFPPADSVVKAARVSGMAGYEALCAEANKDPEGFWARLAREHLQWTKPFTQTLDESKAPFYQWF
ADGELNASANCLDKHMGTPVENKAAILFEADDGTVTQVTYRQLLERVSQFANALKAHGVQQGDRVLIYMPMGVEGVVAMQ
ACARIGATHSVVFGGFSAKALNERIIDAGAVAVITANYQLRGGKELPLKAIVDEGLSMGGCDSIKNVFVYQRTATACDMV
AGRDKTFSEILAGQSTECPPTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKVTMEWTFDIRPDDVFWCTADIGWI
TGHTYVAYGPLAAGATQVVFEGVPTYPNAGRFWQMIERHKVTVFYTAPTAIRSLIKAADSDESVHPKNWDLSSLRILGSV
GEPINPEAWMWYYRHVGGERCPIVDTFWQTENGGHVITPLPGATPLVPGSCTLPLPGIQAAIVDETGKDLPNGAGGMLVI
KRPWPSMIRTIWGDPERFKKSYFPEELGGTTYLAGDGAVRSADRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLV
AEAAVVGRPDDLTGEAICAFVVLKRSRPTGEEAKQIATELRNWVAKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIA
KGEPITQDTSTLENPAILDQLAQSN
>Mature_664_residues
SASSNAIESVLVENRVFPPADSVVKAARVSGMAGYEALCAEANKDPEGFWARLAREHLQWTKPFTQTLDESKAPFYQWFA
DGELNASANCLDKHMGTPVENKAAILFEADDGTVTQVTYRQLLERVSQFANALKAHGVQQGDRVLIYMPMGVEGVVAMQA
CARIGATHSVVFGGFSAKALNERIIDAGAVAVITANYQLRGGKELPLKAIVDEGLSMGGCDSIKNVFVYQRTATACDMVA
GRDKTFSEILAGQSTECPPTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKVTMEWTFDIRPDDVFWCTADIGWIT
GHTYVAYGPLAAGATQVVFEGVPTYPNAGRFWQMIERHKVTVFYTAPTAIRSLIKAADSDESVHPKNWDLSSLRILGSVG
EPINPEAWMWYYRHVGGERCPIVDTFWQTENGGHVITPLPGATPLVPGSCTLPLPGIQAAIVDETGKDLPNGAGGMLVIK
RPWPSMIRTIWGDPERFKKSYFPEELGGTTYLAGDGAVRSADRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLVA
EAAVVGRPDDLTGEAICAFVVLKRSRPTGEEAKQIATELRNWVAKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAK
GEPITQDTSTLENPAILDQLAQSN

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=678, Percent_Identity=46.165191740413, Blast_Score=570, Evalue=1e-162,
Organism=Homo sapiens, GI253970489, Length=694, Percent_Identity=45.3890489913545, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI28416953, Length=631, Percent_Identity=47.5435816164818, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI13375727, Length=637, Percent_Identity=36.8916797488226, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI42544132, Length=538, Percent_Identity=28.4386617100372, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI122937307, Length=598, Percent_Identity=27.4247491638796, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI31982927, Length=659, Percent_Identity=25.0379362670713, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI38505220, Length=536, Percent_Identity=28.544776119403, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI58082049, Length=521, Percent_Identity=27.6391554702495, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI115511026, Length=577, Percent_Identity=26.1698440207972, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI157311624, Length=521, Percent_Identity=27.063339731286, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI157311622, Length=521, Percent_Identity=27.063339731286, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI187761345, Length=405, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI187761343, Length=405, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI156151445, Length=592, Percent_Identity=24.3243243243243, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI42544134, Length=370, Percent_Identity=24.0540540540541, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI195947378, Length=439, Percent_Identity=23.4624145785877, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1790505, Length=635, Percent_Identity=49.9212598425197, Blast_Score=613, Evalue=1e-176,
Organism=Escherichia coli, GI1786529, Length=627, Percent_Identity=37.9585326953748, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI145693145, Length=524, Percent_Identity=24.4274809160305, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788107, Length=562, Percent_Identity=24.9110320284698, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786810, Length=533, Percent_Identity=21.5759849906191, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982997, Length=668, Percent_Identity=42.3652694610778, Blast_Score=486, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71983001, Length=665, Percent_Identity=42.5563909774436, Blast_Score=486, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17569507, Length=655, Percent_Identity=23.0534351145038, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71985884, Length=435, Percent_Identity=25.9770114942529, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=580, Percent_Identity=24.4827586206897, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994694, Length=574, Percent_Identity=24.2160278745645, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994690, Length=574, Percent_Identity=24.2160278745645, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994703, Length=574, Percent_Identity=24.2160278745645, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=645, Percent_Identity=47.5968992248062, Blast_Score=572, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6319264, Length=663, Percent_Identity=47.8129713423831, Blast_Score=564, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6319699, Length=564, Percent_Identity=24.113475177305, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24667955, Length=672, Percent_Identity=45.9821428571429, Blast_Score=570, Evalue=1e-162,
Organism=Drosophila melanogaster, GI62472339, Length=559, Percent_Identity=50.8050089445438, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24667959, Length=528, Percent_Identity=50, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI21355225, Length=638, Percent_Identity=33.3855799373041, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI21355181, Length=558, Percent_Identity=25.2688172043011, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24581924, Length=551, Percent_Identity=23.956442831216, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72279; Mature: 72148

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSNAIESVLVENRVFPPADSVVKAARVSGMAGYEALCAEANKDPEGFWARLAREHLQ
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
WTKPFTQTLDESKAPFYQWFADGELNASANCLDKHMGTPVENKAAILFEADDGTVTQVTY
HCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHH
RQLLERVSQFANALKAHGVQQGDRVLIYMPMGVEGVVAMQACARIGATHSVVFGGFSAKA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHH
LNERIIDAGAVAVITANYQLRGGKELPLKAIVDEGLSMGGCDSIKNVFVYQRTATACDMV
HHHHHHCCCEEEEEEECEEECCCCCCCHHHHHHCCCCCCCCHHHHHEEEEEECHHHHHHH
AGRDKTFSEILAGQSTECPPTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKVTME
CCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEE
WTFDIRPDDVFWCTADIGWITGHTYVAYGPLAAGATQVVFEGVPTYPNAGRFWQMIERHK
EEEECCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCCCCCCCCHHHHHHHHHCC
VTVFYTAPTAIRSLIKAADSDESVHPKNWDLSSLRILGSVGEPINPEAWMWYYRHVGGER
EEEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
CPIVDTFWQTENGGHVITPLPGATPLVPGSCTLPLPGIQAAIVDETGKDLPNGAGGMLVI
CCEEEHHEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEE
KRPWPSMIRTIWGDPERFKKSYFPEELGGTTYLAGDGAVRSADRGYFRITGRIDDVLNVS
ECCCHHHHHHHCCCHHHHHHHCCHHHHCCEEEEECCCCCCCCCCCEEEEECCCCHHHCCC
GHRMGTMEIESALVAKTDLVAEAAVVGRPDDLTGEAICAFVVLKRSRPTGEEAKQIATEL
CCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
RNWVAKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEPITQDTSTLENPAILDQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHH
LAQSN
HHHCC
>Mature Secondary Structure 
SASSNAIESVLVENRVFPPADSVVKAARVSGMAGYEALCAEANKDPEGFWARLAREHLQ
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
WTKPFTQTLDESKAPFYQWFADGELNASANCLDKHMGTPVENKAAILFEADDGTVTQVTY
HCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHH
RQLLERVSQFANALKAHGVQQGDRVLIYMPMGVEGVVAMQACARIGATHSVVFGGFSAKA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHH
LNERIIDAGAVAVITANYQLRGGKELPLKAIVDEGLSMGGCDSIKNVFVYQRTATACDMV
HHHHHHCCCEEEEEEECEEECCCCCCCHHHHHHCCCCCCCCHHHHHEEEEEECHHHHHHH
AGRDKTFSEILAGQSTECPPTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKVTME
CCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEE
WTFDIRPDDVFWCTADIGWITGHTYVAYGPLAAGATQVVFEGVPTYPNAGRFWQMIERHK
EEEECCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCCCCCCCCHHHHHHHHHCC
VTVFYTAPTAIRSLIKAADSDESVHPKNWDLSSLRILGSVGEPINPEAWMWYYRHVGGER
EEEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
CPIVDTFWQTENGGHVITPLPGATPLVPGSCTLPLPGIQAAIVDETGKDLPNGAGGMLVI
CCEEEHHEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEE
KRPWPSMIRTIWGDPERFKKSYFPEELGGTTYLAGDGAVRSADRGYFRITGRIDDVLNVS
ECCCHHHHHHHCCCHHHHHHHCCHHHHCCEEEEECCCCCCCCCCCEEEEECCCCHHHCCC
GHRMGTMEIESALVAKTDLVAEAAVVGRPDDLTGEAICAFVVLKRSRPTGEEAKQIATEL
CCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
RNWVAKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEPITQDTSTLENPAILDQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHH
LAQSN
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA