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The map label for this gene is fumC [H]

Identifier: 222110189

GI number: 222110189

Start: 1013057

End: 1014448

Strand: Direct

Name: fumC [H]

Synonym: Dtpsy_0975

Alternate gene names: 222110189

Gene position: 1013057-1014448 (Clockwise)

Preceding gene: 222110186

Following gene: 222110197

Centisome position: 26.68

GC content: 69.04

Gene sequence:

>1392_bases
ATGACTTCCAGCACCCGTATCGAACGCGACACCTTCGGCCCCATCGAGGTGCCGGCCGACAGGCTCTGGGGCGCGCAGAC
GCAGCGCTCGCTGCAGAACTTCGCCATCTCGGGTGAACGACAGCCGCAGGAACTCATCCGCGCGCTGGCGCAGGTCAAGC
GCGCGTCGGCCCGGGTCAACCACGCGCTGGGGCTGCTGGGCGCGGACAAGACGCGCGCCATCGTCGCCGCGGCCGACGAG
GTGCTGCTGGGCGAGCACGACGACGAGTTCCCGCTGGTGGTCTGGCAGACCGGCTCGGGCACCCAGACCAACATGAACGT
CAACGAGGTGCTGGCCAACCGCGCCAGCGAGCTGTTGGGCGGCGAGCGCGGCGAGGCACGGCTCGTACATCCCAACGATG
ACGTGAACAAGAGCCAGTCCAGCAACGACGTGTTCCCCACCGCCACGCATGTGGCCGCGGTGCAGGCGCTGGTGCACCGG
CTGTTGCCCGCCATGGAGGAGCTGCGCGCCACCCTGCAGGCCAAGGCCGAGGCGTTCGACGACATCGTGAAGATCGGCCG
CACCCATCTGCAGGATGCGACGCCGCTCACGCTGGGGCAGGAAATCTCGGGCTGGGTGGCGCAGCTTGCCCATGGGGAGC
GCCACGTGCGCGCGGCGCTGCCGCACCTGCATGAACTGGCCCTGGGCGGGACGGCCGTGGGCACGGGCCTGAATGCGCCC
GAGGGCTACGCCGAACGTGTGGCGCAGGAGCTGGCCCAGTTCACCGGCCAGCCCTTCGTGACCTCGCCCAACAAGTTCGA
ATCGCTCGCATCGCAGGACGCGCTGGTGCATGCCCACGGCGCGCTGAAGACGCTGGCGGCCAGCCTCACGAAGATCGCCA
ACGACGTGCGGTGGCTGGCCAGCGGCCCGCGCAGCGGCATCGGCGAGATCACCATCCCTGAGAACGAGCCCGGCTCGTCC
ATCATGCCCGGCAAAGTGAACCCCACGCAGTGCGAGGCGCTGACCATGCTGTGCGCCCAGGTGCTGGGCAACGATGTGGC
CATCAACATCGGCGGGGCCAGTGGCAACTTCGAGCTGAACGTGTTCCGCCCGCTGGTGGCGCACAACTTCCTGCAGAGCG
TGCGGTTGCTGGCCGATGGCATGGTGAGCTTCAACGAGCACTGCGCCGTGGGGATAGAGCCCAACCGCGCGCGCATCGCG
GAGCTGGTGGAGCGCTCGCTGATGCTAGTGACGGCGCTCAACCCGCACATCGGCTACGACAAGGCCGCGGCGATTGCCAA
GAAGGCGCACAAGGAAGGCAGCACGCTGCGCGAGGCCGCGCTGGCGCTGGGCCACGTGACGCCCGCGCAGTTCGATGAGT
GGGTGGTGCCCGCCCGGATGGTGGGACGCTAG

Upstream 100 bases:

>100_bases
CCCATCCGCCCGGCGTGGCGGCAGGGGCTTTCAGTGGCCGTGCGGCCATTTGCGGTGAAATCGCACCCGTTGCTCCTTCC
CGGATCAGAAAGGCCTTTGC

Downstream 100 bases:

>100_bases
AGATTCGGCGAGCGCGGGGGCGTGCGCCGCGAGAGGGGAGCGCCTTACTCGTCGCCTCGGCCATCCGCGGCGGCCTGGTC
CACCAGCGTCTGCAGGCCGG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTSSTRIERDTFGPIEVPADRLWGAQTQRSLQNFAISGERQPQELIRALAQVKRASARVNHALGLLGADKTRAIVAAADE
VLLGEHDDEFPLVVWQTGSGTQTNMNVNEVLANRASELLGGERGEARLVHPNDDVNKSQSSNDVFPTATHVAAVQALVHR
LLPAMEELRATLQAKAEAFDDIVKIGRTHLQDATPLTLGQEISGWVAQLAHGERHVRAALPHLHELALGGTAVGTGLNAP
EGYAERVAQELAQFTGQPFVTSPNKFESLASQDALVHAHGALKTLAASLTKIANDVRWLASGPRSGIGEITIPENEPGSS
IMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASGNFELNVFRPLVAHNFLQSVRLLADGMVSFNEHCAVGIEPNRARIA
ELVERSLMLVTALNPHIGYDKAAAIAKKAHKEGSTLREAALALGHVTPAQFDEWVVPARMVGR

Sequences:

>Translated_463_residues
MTSSTRIERDTFGPIEVPADRLWGAQTQRSLQNFAISGERQPQELIRALAQVKRASARVNHALGLLGADKTRAIVAAADE
VLLGEHDDEFPLVVWQTGSGTQTNMNVNEVLANRASELLGGERGEARLVHPNDDVNKSQSSNDVFPTATHVAAVQALVHR
LLPAMEELRATLQAKAEAFDDIVKIGRTHLQDATPLTLGQEISGWVAQLAHGERHVRAALPHLHELALGGTAVGTGLNAP
EGYAERVAQELAQFTGQPFVTSPNKFESLASQDALVHAHGALKTLAASLTKIANDVRWLASGPRSGIGEITIPENEPGSS
IMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASGNFELNVFRPLVAHNFLQSVRLLADGMVSFNEHCAVGIEPNRARIA
ELVERSLMLVTALNPHIGYDKAAAIAKKAHKEGSTLREAALALGHVTPAQFDEWVVPARMVGR
>Mature_462_residues
TSSTRIERDTFGPIEVPADRLWGAQTQRSLQNFAISGERQPQELIRALAQVKRASARVNHALGLLGADKTRAIVAAADEV
LLGEHDDEFPLVVWQTGSGTQTNMNVNEVLANRASELLGGERGEARLVHPNDDVNKSQSSNDVFPTATHVAAVQALVHRL
LPAMEELRATLQAKAEAFDDIVKIGRTHLQDATPLTLGQEISGWVAQLAHGERHVRAALPHLHELALGGTAVGTGLNAPE
GYAERVAQELAQFTGQPFVTSPNKFESLASQDALVHAHGALKTLAASLTKIANDVRWLASGPRSGIGEITIPENEPGSSI
MPGKVNPTQCEALTMLCAQVLGNDVAINIGGASGNFELNVFRPLVAHNFLQSVRLLADGMVSFNEHCAVGIEPNRARIAE
LVERSLMLVTALNPHIGYDKAAAIAKKAHKEGSTLREAALALGHVTPAQFDEWVVPARMVGR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=61.4718614718615, Blast_Score=567, Evalue=1e-162,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=46.7532467532467, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=74.5652173913043, Blast_Score=689, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=456, Percent_Identity=40.7894736842105, Blast_Score=350, Evalue=9e-98,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=60.9544468546638, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=61.8461538461539, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=57.7586206896552, Blast_Score=544, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=59.7826086956522, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=59.7826086956522, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=58.5683297180043, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=59.0909090909091, Blast_Score=566, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=51.2987012987013, Blast_Score=486, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49572; Mature: 49441

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSTRIERDTFGPIEVPADRLWGAQTQRSLQNFAISGERQPQELIRALAQVKRASARVN
CCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
HALGLLGADKTRAIVAAADEVLLGEHDDEFPLVVWQTGSGTQTNMNVNEVLANRASELLG
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARLVHPNDDVNKSQSSNDVFPTATHVAAVQALVHRLLPAMEELRATLQAKAEAFD
CCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEISGWVAQLAHGERHVRAALPHLHELALGGTAVGTGLNAP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCCCC
EGYAERVAQELAQFTGQPFVTSPNKFESLASQDALVHAHGALKTLAASLTKIANDVRWLA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRSGIGEITIPENEPGSSIMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASGNFELN
CCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPLVAHNFLQSVRLLADGMVSFNEHCAVGIEPNRARIAELVERSLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCH
KAAAIAKKAHKEGSTLREAALALGHVTPAQFDEWVVPARMVGR
HHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TSSTRIERDTFGPIEVPADRLWGAQTQRSLQNFAISGERQPQELIRALAQVKRASARVN
CCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
HALGLLGADKTRAIVAAADEVLLGEHDDEFPLVVWQTGSGTQTNMNVNEVLANRASELLG
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARLVHPNDDVNKSQSSNDVFPTATHVAAVQALVHRLLPAMEELRATLQAKAEAFD
CCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEISGWVAQLAHGERHVRAALPHLHELALGGTAVGTGLNAP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCCCC
EGYAERVAQELAQFTGQPFVTSPNKFESLASQDALVHAHGALKTLAASLTKIANDVRWLA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRSGIGEITIPENEPGSSIMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASGNFELN
CCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPLVAHNFLQSVRLLADGMVSFNEHCAVGIEPNRARIAELVERSLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCH
KAAAIAKKAHKEGSTLREAALALGHVTPAQFDEWVVPARMVGR
HHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]