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The map label for this gene is parC [H]

Identifier: 222110144

GI number: 222110144

Start: 951829

End: 954183

Strand: Direct

Name: parC [H]

Synonym: Dtpsy_0930

Alternate gene names: 222110144

Gene position: 951829-954183 (Clockwise)

Preceding gene: 222110143

Following gene: 222110145

Centisome position: 25.07

GC content: 69.0

Gene sequence:

>2355_bases
ATGAGCGACCAACCCACTCTCGACTTCTCCGCGCCCGCCGACCACGGCGACAGCCTAGAACTGGCCGGCTACGCCCAGCG
CGCCTATCTGGAATACGCCCTCTCGGTCGTCAAGGGCCGCGCGCTGCCCGACGTGTGCGACGGCCTCAAGCCCGTGCAGC
GGCGCATCCTCTACGCCATGGACCGCATGGGCCTGGGCTACAGCGGGCCAAACCGCAACGTGGCGGCCAAGCCCGTCAAA
AGCGCCCGCGTGGTGGGCGACGTGCTGGGCCGCTTTCACCCGCACGGCGACCAGTCGGCCTACGACGCACTGGTGCGCTT
GGCGCAGGACTTCAACCAGCGCTACCCGCTGATCGACGGCCAGGGCAACTTCGGCAGCCGCGATGGCGACGGCGCGGCGG
CCATGCGCTACACCGAGGCGCGTTTGACCCGCATCGCTGGCCTGCTGCTGGACGAGATCGACATGGGCACGGTGGATTTC
GTGCCCAACTACGACGGCAGCACGCAGGAGCCGCGCCAGCTGCCCGCGCGGTTGCCATTCGCGCTGCTCAACGGCGCCAG
CGGCATCGCCGTGGGTCTGGCCACGGAGATCCCCAGCCACAACCTGCGCGAGGTGGCCGACGCCTGCGTGGCCCTGGTCA
AGAAGCCGCAGCTGAGCGACGAGGAGCTGTTCGCGCTGGTCCCCGGCCCTGACTACCCGGGCGGCGGCCAGATCATCAGC
ACTGATGCGGACATCCAGGACGCCTACCGCACGGGCCGCGGCAGCCTCAAGGTGCGCGCGCGCTGGAAGATCGAGGACCT
GGCGCGCGGCCAGTGGCAGATGGTGGTGACCGAGCTGCCGCCCGGCGTCTCCGCGCAGAAGGTGCTGGAGGAGATCGAGG
AGCTCACCAACCCCAAGGTCAAGACCGGCAAGAAGGCGCTCACGCAGGAGCAGACGCAGCTCAAGGCTGCCTTGCTGGCG
CTGCTGGACGGCGTGCGCGACGAGTCCAGCAAGGACGCGCCGGTGCGCCTGGTCATCGAACCCAAGACCGGCAAGGTGCC
GCAGCAGGACCTCATCACCGCGCTGCTGGCGCACACCAGCCTGGAGACTTCCGCGCCCATCAACCTGACCATGGTGGGGC
TGGACGGCAGGCCCGTGCAGAAGTCGCTGCGCGAGATGCTGCAGGAGTGGATCGACTTCCGCCAGACCACCATCACGCGG
CGCAGCCAGCACCGGCTGGACAAGGTGCTGGACCGCATCCACATCCTGGAGGGGCGGCAGCTGGTGCTGCTGAACATCGA
CGAGGTGATCGCCATCATCCGCCAGGCCGACGAGCCGAAGGCGGCGCTGATCGCGCGCTTTCACCTGTCGGACCGCCAGG
CCGAGGACATTCTGGAAATCCGCCTGCGCCAACTGGCGCGGCTGGAAGCCATCAAGATCGAGCAGGAGCTGAAAGAGCTG
CGCGACGAGCAGGGCAAGCTGGAGGACATCCTCGCCAACCCCGCCTCGCTGCGCCGCCTGATGGCCAAGGAGATCGAGGC
AGACGCCAAGCTGTTCGGCGACGCGCGCCGCACGCTGATCCAGGCCGAAAAGAAGGCCGTGGCCGAGGTCAAGGTGCTGG
ACGAACCCGTCACCGTGGTGGTGTCCGAAAAGGGCTGGGTGCGTGCGCGCCAGGGCCACGGGCACGAGGCGGGCAGCTTC
GCCTTCAAGTCGGGCGACGGCCTGTACGGCACCTTTGAGTGCCGCACGGTGGACACGCTCATCGTCTTCGGCAGCAACGG
GCGGGTGTACTCGGTGGCCGTGTCCAGCCTGCCGGGCGGGCGTGGCGACGGCCAGCCCATCACCACGCTGATCGAGCTGG
AGGCCGGCACGCAGCCGGTGCACTACTTCGCCGGACCGGCCAACGCAGCGCTGCTGCTTGCAGGCTCGGGCGGCTATGGT
TTCCTGTCCACCGTGGAGCACATGACCGCACGCAACCGTGGCGGCAAGGCCTTTGTGAACCTGGGTGAGGGCGAACGCCT
GTGCCGCCCCTCGCATGCGGCGTTCACCAGCGGCAGCCAGCCGCTGGCGCCCGCCACCCATGTGTGCTGCGCATCCGTGG
GTGGGCGAGTGCTCACGTTTGAGATCGCCGAACTCAAGCTCATGGAAAAGGGCGGCCGCGGGCTGATGCTCATCGACCTG
GAGCCCAAGGACCAACTGGCCGGCGCGGCGGCCTACACGCGCAGCGTGCGCTTCGTGGGCGTGGGCCGTGGCGGCAAGCC
GCGCGAGGAGCAACTGGAGATCCGCTCGCTCAACAACGCGCGCGCGGCGCGCGGGCGCAAGGGCAAGGCGGCCGACTTGG
GTTTCAAGCCGTCCGACGTGCTGCGCGTGGAGTGA

Upstream 100 bases:

>100_bases
CACTATCCGATGCCGGTGAGCGCGCCGACACGCAGCGCATGTCCACGCCTGCGCCCACGCGCCTGGCCCGGCAGTCATCG
ACCGAGTCTGTCTTCACTGA

Downstream 100 bases:

>100_bases
TTCAAAAACAATAGCTGGTCGCGCTTGCTGGTACAAGCTTTTACGGATAAAAGCCGTTGAAGTTCCGGTGTAGAAAGCGC
GAGAAGCTATTTTTTTGATA

Product: DNA topoisomerase IV subunit a

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MSDQPTLDFSAPADHGDSLELAGYAQRAYLEYALSVVKGRALPDVCDGLKPVQRRILYAMDRMGLGYSGPNRNVAAKPVK
SARVVGDVLGRFHPHGDQSAYDALVRLAQDFNQRYPLIDGQGNFGSRDGDGAAAMRYTEARLTRIAGLLLDEIDMGTVDF
VPNYDGSTQEPRQLPARLPFALLNGASGIAVGLATEIPSHNLREVADACVALVKKPQLSDEELFALVPGPDYPGGGQIIS
TDADIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKVKTGKKALTQEQTQLKAALLA
LLDGVRDESSKDAPVRLVIEPKTGKVPQQDLITALLAHTSLETSAPINLTMVGLDGRPVQKSLREMLQEWIDFRQTTITR
RSQHRLDKVLDRIHILEGRQLVLLNIDEVIAIIRQADEPKAALIARFHLSDRQAEDILEIRLRQLARLEAIKIEQELKEL
RDEQGKLEDILANPASLRRLMAKEIEADAKLFGDARRTLIQAEKKAVAEVKVLDEPVTVVVSEKGWVRARQGHGHEAGSF
AFKSGDGLYGTFECRTVDTLIVFGSNGRVYSVAVSSLPGGRGDGQPITTLIELEAGTQPVHYFAGPANAALLLAGSGGYG
FLSTVEHMTARNRGGKAFVNLGEGERLCRPSHAAFTSGSQPLAPATHVCCASVGGRVLTFEIAELKLMEKGGRGLMLIDL
EPKDQLAGAAAYTRSVRFVGVGRGGKPREEQLEIRSLNNARAARGRKGKAADLGFKPSDVLRVE

Sequences:

>Translated_784_residues
MSDQPTLDFSAPADHGDSLELAGYAQRAYLEYALSVVKGRALPDVCDGLKPVQRRILYAMDRMGLGYSGPNRNVAAKPVK
SARVVGDVLGRFHPHGDQSAYDALVRLAQDFNQRYPLIDGQGNFGSRDGDGAAAMRYTEARLTRIAGLLLDEIDMGTVDF
VPNYDGSTQEPRQLPARLPFALLNGASGIAVGLATEIPSHNLREVADACVALVKKPQLSDEELFALVPGPDYPGGGQIIS
TDADIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKVKTGKKALTQEQTQLKAALLA
LLDGVRDESSKDAPVRLVIEPKTGKVPQQDLITALLAHTSLETSAPINLTMVGLDGRPVQKSLREMLQEWIDFRQTTITR
RSQHRLDKVLDRIHILEGRQLVLLNIDEVIAIIRQADEPKAALIARFHLSDRQAEDILEIRLRQLARLEAIKIEQELKEL
RDEQGKLEDILANPASLRRLMAKEIEADAKLFGDARRTLIQAEKKAVAEVKVLDEPVTVVVSEKGWVRARQGHGHEAGSF
AFKSGDGLYGTFECRTVDTLIVFGSNGRVYSVAVSSLPGGRGDGQPITTLIELEAGTQPVHYFAGPANAALLLAGSGGYG
FLSTVEHMTARNRGGKAFVNLGEGERLCRPSHAAFTSGSQPLAPATHVCCASVGGRVLTFEIAELKLMEKGGRGLMLIDL
EPKDQLAGAAAYTRSVRFVGVGRGGKPREEQLEIRSLNNARAARGRKGKAADLGFKPSDVLRVE
>Mature_783_residues
SDQPTLDFSAPADHGDSLELAGYAQRAYLEYALSVVKGRALPDVCDGLKPVQRRILYAMDRMGLGYSGPNRNVAAKPVKS
ARVVGDVLGRFHPHGDQSAYDALVRLAQDFNQRYPLIDGQGNFGSRDGDGAAAMRYTEARLTRIAGLLLDEIDMGTVDFV
PNYDGSTQEPRQLPARLPFALLNGASGIAVGLATEIPSHNLREVADACVALVKKPQLSDEELFALVPGPDYPGGGQIIST
DADIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKVKTGKKALTQEQTQLKAALLAL
LDGVRDESSKDAPVRLVIEPKTGKVPQQDLITALLAHTSLETSAPINLTMVGLDGRPVQKSLREMLQEWIDFRQTTITRR
SQHRLDKVLDRIHILEGRQLVLLNIDEVIAIIRQADEPKAALIARFHLSDRQAEDILEIRLRQLARLEAIKIEQELKELR
DEQGKLEDILANPASLRRLMAKEIEADAKLFGDARRTLIQAEKKAVAEVKVLDEPVTVVVSEKGWVRARQGHGHEAGSFA
FKSGDGLYGTFECRTVDTLIVFGSNGRVYSVAVSSLPGGRGDGQPITTLIELEAGTQPVHYFAGPANAALLLAGSGGYGF
LSTVEHMTARNRGGKAFVNLGEGERLCRPSHAAFTSGSQPLAPATHVCCASVGGRVLTFEIAELKLMEKGGRGLMLIDLE
PKDQLAGAAAYTRSVRFVGVGRGGKPREEQLEIRSLNNARAARGRKGKAADLGFKPSDVLRVE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=366, Percent_Identity=26.5027322404372, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=32.5714285714286, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1789396, Length=767, Percent_Identity=43.0247718383312, Blast_Score=593, Evalue=1e-170,
Organism=Escherichia coli, GI1788562, Length=752, Percent_Identity=37.3670212765958, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535065, Length=472, Percent_Identity=27.3305084745763, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=538, Percent_Identity=26.3940520446097, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=279, Percent_Identity=26.1648745519713, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=194, Percent_Identity=32.9896907216495, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136538, Length=267, Percent_Identity=26.5917602996255, Blast_Score=79, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85264; Mature: 85132

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQPTLDFSAPADHGDSLELAGYAQRAYLEYALSVVKGRALPDVCDGLKPVQRRILYAM
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHH
DRMGLGYSGPNRNVAAKPVKSARVVGDVLGRFHPHGDQSAYDALVRLAQDFNQRYPLIDG
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEECC
QGNFGSRDGDGAAAMRYTEARLTRIAGLLLDEIDMGTVDFVPNYDGSTQEPRQLPARLPF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHCHHHCCH
ALLNGASGIAVGLATEIPSHNLREVADACVALVKKPQLSDEELFALVPGPDYPGGGQIIS
HHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEE
TDADIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKV
CCCCHHHHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCC
KTGKKALTQEQTQLKAALLALLDGVRDESSKDAPVRLVIEPKTGKVPQQDLITALLAHTS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCC
LETSAPINLTMVGLDGRPVQKSLREMLQEWIDFRQTTITRRSQHRLDKVLDRIHILEGRQ
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LVLLNIDEVIAIIRQADEPKAALIARFHLSDRQAEDILEIRLRQLARLEAIKIEQELKEL
EEEEEHHHHHHHHHCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDEQGKLEDILANPASLRRLMAKEIEADAKLFGDARRTLIQAEKKAVAEVKVLDEPVTVV
HHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEE
VSEKGWVRARQGHGHEAGSFAFKSGDGLYGTFECRTVDTLIVFGSNGRVYSVAVSSLPGG
EECCCCEEECCCCCCCCCCEEEECCCCCEEEEEEEEEEEEEEECCCCCEEEEEEECCCCC
RGDGQPITTLIELEAGTQPVHYFAGPANAALLLAGSGGYGFLSTVEHMTARNRGGKAFVN
CCCCCCEEEEEEECCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEE
LGEGERLCRPSHAAFTSGSQPLAPATHVCCASVGGRVLTFEIAELKLMEKGGRGLMLIDL
CCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHCCCCEEEEEEE
EPKDQLAGAAAYTRSVRFVGVGRGGKPREEQLEIRSLNNARAARGRKGKAADLGFKPSDV
CCHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCC
LRVE
EECC
>Mature Secondary Structure 
SDQPTLDFSAPADHGDSLELAGYAQRAYLEYALSVVKGRALPDVCDGLKPVQRRILYAM
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHH
DRMGLGYSGPNRNVAAKPVKSARVVGDVLGRFHPHGDQSAYDALVRLAQDFNQRYPLIDG
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEECC
QGNFGSRDGDGAAAMRYTEARLTRIAGLLLDEIDMGTVDFVPNYDGSTQEPRQLPARLPF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHCHHHCCH
ALLNGASGIAVGLATEIPSHNLREVADACVALVKKPQLSDEELFALVPGPDYPGGGQIIS
HHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEE
TDADIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKV
CCCCHHHHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCC
KTGKKALTQEQTQLKAALLALLDGVRDESSKDAPVRLVIEPKTGKVPQQDLITALLAHTS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCC
LETSAPINLTMVGLDGRPVQKSLREMLQEWIDFRQTTITRRSQHRLDKVLDRIHILEGRQ
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LVLLNIDEVIAIIRQADEPKAALIARFHLSDRQAEDILEIRLRQLARLEAIKIEQELKEL
EEEEEHHHHHHHHHCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDEQGKLEDILANPASLRRLMAKEIEADAKLFGDARRTLIQAEKKAVAEVKVLDEPVTVV
HHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEE
VSEKGWVRARQGHGHEAGSFAFKSGDGLYGTFECRTVDTLIVFGSNGRVYSVAVSSLPGG
EECCCCEEECCCCCCCCCCEEEECCCCCEEEEEEEEEEEEEEECCCCCEEEEEEECCCCC
RGDGQPITTLIELEAGTQPVHYFAGPANAALLLAGSGGYGFLSTVEHMTARNRGGKAFVN
CCCCCCEEEEEEECCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEE
LGEGERLCRPSHAAFTSGSQPLAPATHVCCASVGGRVLTFEIAELKLMEKGGRGLMLIDL
CCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHCCCCEEEEEEE
EPKDQLAGAAAYTRSVRFVGVGRGGKPREEQLEIRSLNNARAARGRKGKAADLGFKPSDV
CCHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCC
LRVE
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]