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The map label for this gene is dut [H]

Identifier: 222110131

GI number: 222110131

Start: 939987

End: 940433

Strand: Direct

Name: dut [H]

Synonym: Dtpsy_0917

Alternate gene names: 222110131

Gene position: 939987-940433 (Clockwise)

Preceding gene: 222110130

Following gene: 222110132

Centisome position: 24.76

GC content: 66.67

Gene sequence:

>447_bases
ATGAAAATCGACGTCAAGATTCTCGACCCCCGCATGGCGGATCAATTGCCAACGTATGCCACGCCCGGCAGCGCGGGGCT
GGACCTGCGCGCGTGCCTGGACGCGCCGCTCACGCTGGAGCCCAACGCCTGGCAATTGGTGCCCACGGGCATCGCCATCT
ACCTTCAGGACCCGGGCTATGCCGCGCTGATCCTGCCGCGCTCGGGGCTGGGCCACAAGCACGGCATCGTGCTGGGCAAC
CTGGTGGGCCTGATCGACAGCGACTACCAGGGGCAACTCATGGTCAGCGCGTGGAACCGCAGCCCCCAGGCCTTCACCCT
GCAACCCATGGAGCGTCTGGCGCAGTTGGTCATCGTGCCGGTGGTGCAAGCCCAGTTCAACGTGGTGCAGGAGTTTCCGG
CCAGCGAGCGCGGTGAGGGCGGCTACGGCTCCACGGGCAAGCACTGA

Upstream 100 bases:

>100_bases
TGAGCGGGTAGGGGCGCACCGGTTGGGCGATGATCGCGGGTTCGGCCCGCGGTGCTGCCGGCGTGACACCGCGCGACCAT
TCCTTTGAACCTCTGCTCCC

Downstream 100 bases:

>100_bases
GCGCCAGCGCCGCTGTCGGCCCCTGCCTACATGGCCGGAGCGCACTTCACTACGAGGCCCGCCGGGCATGGCCGGCAGCG
TGGAGGATGCCGCGGTGCTT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKIDVKILDPRMADQLPTYATPGSAGLDLRACLDAPLTLEPNAWQLVPTGIAIYLQDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMVSAWNRSPQAFTLQPMERLAQLVIVPVVQAQFNVVQEFPASERGEGGYGSTGKH

Sequences:

>Translated_148_residues
MKIDVKILDPRMADQLPTYATPGSAGLDLRACLDAPLTLEPNAWQLVPTGIAIYLQDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMVSAWNRSPQAFTLQPMERLAQLVIVPVVQAQFNVVQEFPASERGEGGYGSTGKH
>Mature_148_residues
MKIDVKILDPRMADQLPTYATPGSAGLDLRACLDAPLTLEPNAWQLVPTGIAIYLQDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMVSAWNRSPQAFTLQPMERLAQLVIVPVVQAQFNVVQEFPASERGEGGYGSTGKH

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=132, Percent_Identity=37.1212121212121, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4503423, Length=132, Percent_Identity=37.1212121212121, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI70906441, Length=132, Percent_Identity=37.1212121212121, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI1790071, Length=149, Percent_Identity=67.1140939597315, Blast_Score=213, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71988561, Length=133, Percent_Identity=38.3458646616541, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319729, Length=133, Percent_Identity=36.8421052631579, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583610, Length=149, Percent_Identity=32.2147651006711, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19921126, Length=151, Percent_Identity=32.4503311258278, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15948; Mature: 15948

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDVKILDPRMADQLPTYATPGSAGLDLRACLDAPLTLEPNAWQLVPTGIAIYLQDPGY
CEEEEEEECCCCHHCCCCCCCCCCCCCEEHHHCCCCEEECCCCEEEEECCEEEEEECCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSAWNRSPQAFTLQPMERLAQLVIVP
EEEEEECCCCCCCCCEEEEHEEECCCCCCCCEEEEEECCCCCCEEEECHHHHHHHHHHHH
VVQAQFNVVQEFPASERGEGGYGSTGKH
HHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIDVKILDPRMADQLPTYATPGSAGLDLRACLDAPLTLEPNAWQLVPTGIAIYLQDPGY
CEEEEEEECCCCHHCCCCCCCCCCCCCEEHHHCCCCEEECCCCEEEEECCEEEEEECCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSAWNRSPQAFTLQPMERLAQLVIVP
EEEEEECCCCCCCCCEEEEHEEECCCCCCCCEEEEEECCCCCCEEEECHHHHHHHHHHHH
VVQAQFNVVQEFPASERGEGGYGSTGKH
HHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA