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The map label for this gene is coaBC [H]

Identifier: 222110130

GI number: 222110130

Start: 938669

End: 939889

Strand: Direct

Name: coaBC [H]

Synonym: Dtpsy_0916

Alternate gene names: 222110130

Gene position: 938669-939889 (Clockwise)

Preceding gene: 222110123

Following gene: 222110131

Centisome position: 24.72

GC content: 67.08

Gene sequence:

>1221_bases
ATGAACGAACAGTTGGCTGGCAAACACATTGTCCTGGGCTTGAGCGGCGGCGTGGCCTGCTACAAATCGGCGGAACTGTG
CCGGCTGCTGGTGAAGGCAGGCGCTACGGTACAGGTGGTGATGACCGAAGCGGCCGCGCAGTTCATCACGCCCGTGACCA
TGCAGGCGCTGTCGGGCCGCAGCGTGTACACCTCGCAGTGGGATACGCGCGAGGCGAACAACATGCCCCATATCAACCTG
AGCCGCGAGGCGGACGCGATCCTCATTGCTCCGTGCAGCGCGGACTTCATTGCGCGGCTGGTGCAGGGGCGGGCCGACGA
GTTATTGAGCCTGCTGTGTCTGGCACGGCCCCGGGATCGGGTGCCGTTGCTACTGGCGCCCGCTATGAACCGCGAGATGT
GGGGCCACCCGGCCACACAGCGCAACCTGGCCCAGGTGGCGCGCGACGGCGCAACGGTGCTGGGCGTGGGCTTTGGCGAC
CAGGCCTGTGGCGAGACGGGCGACGGCCGCATGCTGGAGGCCGCGGAGATTCTGGAGGAACTGGAGGCCTTCTTTACCCC
CCAGTTGCTCACGGGCCAGCACGTGCTGATTACCGCAGGCCCCACCTTCGAGGCCATTGACCCGGTGCGCGGCATCACCA
ACCTGTCCAGCGGCAAGATGGGCTTTGCGATTGCCCGCGCGGCGCGTGCCGCTGGCGCACAGGTCACATTGGTCGCCGGG
CCGGTGCATCTGCCCACCCCGCGGGGCGTGCGGCGCATCGACGTGCGTTCAGCACAAAATATGCTTGCAATCGTTGAGGA
GCAAGCGCGAGAAGCTACTATTTTCATCGCTACGGCCGCGGTGGCGGACTGGCGTCCCGCCACTGCTGCGCTGCACAAGA
TCAAGAAGGACGGCACGGGCGACGTGCCGGCGCTGGAGTTTGTGGAGAACCCCGACATCCTGGCCACGGTGGCGCGCACC
GAGCGCGCGCGCGCTGGCCGTCTGTACTGTGTGGGGTTTGCCGCCGAGAGCGAGAACCTGCTGGAGCATGCCAGCGCCAA
GCGCGAGCGCAAGGGCGTGCCGTTGCTGGTGGGCAATATCGGCCCGGCCACGTTCGGGCAGGACGACAATGCGCTGCTGC
TGGTCGACGCGCAGGGCCATCGTGAACTGCCCCGTGCTTCCAAGGAGGCGCTGGGCCATCAGCTCGTGGCGGAGATCGCG
CGGCGCCTTGCCGCCGTTTGA

Upstream 100 bases:

>100_bases
TTTGGTCATGTCTTTGATGGTGGTGGGAAATTGGGATTGTAATCAGCCCACTGCAGGGATGCAGTGGCAGGGGCCATGCC
CTCTGCTAAATTGCGCCCCC

Downstream 100 bases:

>100_bases
GCGGGTAGGGGCGCACCGGTTGGGCGATGATCGCGGGTTCGGCCCGCGGTGCTGCCGGCGTGACACCGCGCGACCATTCC
TTTGAACCTCTGCTCCCATG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNEQLAGKHIVLGLSGGVACYKSAELCRLLVKAGATVQVVMTEAAAQFITPVTMQALSGRSVYTSQWDTREANNMPHINL
SREADAILIAPCSADFIARLVQGRADELLSLLCLARPRDRVPLLLAPAMNREMWGHPATQRNLAQVARDGATVLGVGFGD
QACGETGDGRMLEAAEILEELEAFFTPQLLTGQHVLITAGPTFEAIDPVRGITNLSSGKMGFAIARAARAAGAQVTLVAG
PVHLPTPRGVRRIDVRSAQNMLAIVEEQAREATIFIATAAVADWRPATAALHKIKKDGTGDVPALEFVENPDILATVART
ERARAGRLYCVGFAAESENLLEHASAKRERKGVPLLVGNIGPATFGQDDNALLLVDAQGHRELPRASKEALGHQLVAEIA
RRLAAV

Sequences:

>Translated_406_residues
MNEQLAGKHIVLGLSGGVACYKSAELCRLLVKAGATVQVVMTEAAAQFITPVTMQALSGRSVYTSQWDTREANNMPHINL
SREADAILIAPCSADFIARLVQGRADELLSLLCLARPRDRVPLLLAPAMNREMWGHPATQRNLAQVARDGATVLGVGFGD
QACGETGDGRMLEAAEILEELEAFFTPQLLTGQHVLITAGPTFEAIDPVRGITNLSSGKMGFAIARAARAAGAQVTLVAG
PVHLPTPRGVRRIDVRSAQNMLAIVEEQAREATIFIATAAVADWRPATAALHKIKKDGTGDVPALEFVENPDILATVART
ERARAGRLYCVGFAAESENLLEHASAKRERKGVPLLVGNIGPATFGQDDNALLLVDAQGHRELPRASKEALGHQLVAEIA
RRLAAV
>Mature_406_residues
MNEQLAGKHIVLGLSGGVACYKSAELCRLLVKAGATVQVVMTEAAAQFITPVTMQALSGRSVYTSQWDTREANNMPHINL
SREADAILIAPCSADFIARLVQGRADELLSLLCLARPRDRVPLLLAPAMNREMWGHPATQRNLAQVARDGATVLGVGFGD
QACGETGDGRMLEAAEILEELEAFFTPQLLTGQHVLITAGPTFEAIDPVRGITNLSSGKMGFAIARAARAAGAQVTLVAG
PVHLPTPRGVRRIDVRSAQNMLAIVEEQAREATIFIATAAVADWRPATAALHKIKKDGTGDVPALEFVENPDILATVART
ERARAGRLYCVGFAAESENLLEHASAKRERKGVPLLVGNIGPATFGQDDNALLLVDAQGHRELPRASKEALGHQLVAEIA
RRLAAV

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=184, Percent_Identity=33.695652173913, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI87082301, Length=403, Percent_Identity=48.6352357320099, Blast_Score=315, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=30.1587301587302, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43268; Mature: 43268

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQLAGKHIVLGLSGGVACYKSAELCRLLVKAGATVQVVMTEAAAQFITPVTMQALSGR
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCC
SVYTSQWDTREANNMPHINLSREADAILIAPCSADFIARLVQGRADELLSLLCLARPRDR
CEECCCCCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCCCC
VPLLLAPAMNREMWGHPATQRNLAQVARDGATVLGVGFGDQACGETGDGRMLEAAEILEE
CCEEEECCCCHHHCCCCCCHHHHHHHHHCCCEEEEECCCCHHCCCCCCCCEEHHHHHHHH
LEAFFTPQLLTGQHVLITAGPTFEAIDPVRGITNLSSGKMGFAIARAARAAGAQVTLVAG
HHHHHCCCEECCCEEEEEECCCCHHCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEC
PVHLPTPRGVRRIDVRSAQNMLAIVEEQAREATIFIATAAVADWRPATAALHKIKKDGTG
CEECCCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEEEEHHCCCCHHHHHHHHHHCCCCC
DVPALEFVENPDILATVARTERARAGRLYCVGFAAESENLLEHASAKRERKGVPLLVGNI
CCCHHHCCCCCCCEEEHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECC
GPATFGQDDNALLLVDAQGHRELPRASKEALGHQLVAEIARRLAAV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNEQLAGKHIVLGLSGGVACYKSAELCRLLVKAGATVQVVMTEAAAQFITPVTMQALSGR
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCC
SVYTSQWDTREANNMPHINLSREADAILIAPCSADFIARLVQGRADELLSLLCLARPRDR
CEECCCCCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCCCC
VPLLLAPAMNREMWGHPATQRNLAQVARDGATVLGVGFGDQACGETGDGRMLEAAEILEE
CCEEEECCCCHHHCCCCCCHHHHHHHHHCCCEEEEECCCCHHCCCCCCCCEEHHHHHHHH
LEAFFTPQLLTGQHVLITAGPTFEAIDPVRGITNLSSGKMGFAIARAARAAGAQVTLVAG
HHHHHCCCEECCCEEEEEECCCCHHCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEC
PVHLPTPRGVRRIDVRSAQNMLAIVEEQAREATIFIATAAVADWRPATAALHKIKKDGTG
CEECCCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEEEEHHCCCCHHHHHHHHHHCCCCC
DVPALEFVENPDILATVARTERARAGRLYCVGFAAESENLLEHASAKRERKGVPLLVGNI
CCCHHHCCCCCCCEEEHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECC
GPATFGQDDNALLLVDAQGHRELPRASKEALGHQLVAEIARRLAAV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]