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The map label for this gene is nuoN [H]

Identifier: 222110099

GI number: 222110099

Start: 909527

End: 911020

Strand: Direct

Name: nuoN [H]

Synonym: Dtpsy_0885

Alternate gene names: 222110099

Gene position: 909527-911020 (Clockwise)

Preceding gene: 222110098

Following gene: 222110100

Centisome position: 23.96

GC content: 62.18

Gene sequence:

>1494_bases
ATGATTGACAACATCAGCTGGCTGGCGATTTATCCCGAGATCGTGCTGCTGGTCATGGCTTGCGTGATTGCCCTGGTGGA
TCTGGGCGTCAGCAGCGCGCGCCGCACGGGAACCTACGTGCTCACCATGCTCACCCTGGCGGTGGTTGCCGCGCTCCAGG
CCATGTACGCGAGCAGTGGCAACACCTTCTATGCCTGGGGCAACATGGTGGTCAGCGATGCCATGGGCAATTGGCTCAAG
TGCTTCGCGACCGTGGCCGTGATGGTTTTGCTCGTCTATGGCCGTCCCTATGCCGCGGACCGCGACATGCTGCGTGGTGG
TGAGTTGTTCACGCTGACCATGCTCGCTCTGCTGGGGATGTTTGTGCTGATCTCGGCCAACAACTTCCTGCTGATCTATC
TGGGCCTGGAACTGCTCACGCTCTCCAGCTATGCCCTGGTGGCCCTGCGGCGCGACAACACCACGGCCACCGAGGCCGCG
ATGAAGTATTTCGTACTGGGCGCCATGGCCAGCGGCTTCCTGCTGTATGGCCTGTCCATGCTCTACGGCGCCACCGGTTC
GCTGGACATCGGCCAGGTATTCAAGGCCATCAACGCGGGGCAGATCCGTCACCAAGTACTGGTGTTCGGCCTGGTGTTCG
TGGTCGCCGGGCTGGCTTTCAAGATGGGCGTGGTTCCGTTCCATATGTGGGTGCCAGACGTCTACCAGGGCGCGCCCACG
GCCGTGACGCTGTTCATCGGCAGCGCACCCAAGCTGGCCGCGTTCGCCATGACCATCCGCCTGCTGGTGGACGGCCTGTT
GCCGCTGGCCATCGACTGGCAGCAGATGCTTGCGGTACTGGCCATCGGGTCGCTGCTGGTGGGTAACCTGGCTGCGATCA
TGCAGACCAATCTCAAGCGCATGCTGGCGTACTCGACGATCTCGCAGATGGCATTCGTGCTACTGGGCCTGATGTCGGGT
GTGGTGCATGGCAACGTGGACGCCACCGCTGTGGAGAACGCCTACAGCTCCGCCATGTTCTACGTGGTGACCTATGTGCT
CACCACGTTGGCGGCCTTCGGTGTGATCCTGCTGTTGGCGCGCGAAGGTTTTGAAAGCGAAGAAATTTCCGACCTGGCCG
GTCTGAACCAGCGCAGCCCGCTGTACGCAGGCGTGATGGCCGTGTGTCTGTTCTCGATGGCCGGCATTCCGCCGCTGGTC
GGTTTCTATGCCAAGCTGGCCGTGCTGCAAGCGCTGGTCGCGTCCGGGCAGGTACTGCACATCGCCTTGGCGGTATTCGC
CGTCATGATGTCGTTGATCGGCGCGTTTTACTACCTGCGCGTGGTGAAGGTGATGTACTTCGACGCACCATTGACTGCTA
CCAGCGTGTCCGCACCGTTGGACGTGCGTGTGGTGCTGACCATCAATGGCGCTCTGGTCCTGGTCCTGGGATTGCTGCCG
GGTGGGCTGATGGCCCTGTGCGCCGATGCCATCGTGCGCGCCCTCGCCACCTGA

Upstream 100 bases:

>100_bases
CAAGCCCTTCACGGACGTGATGGATGTGTCCGTGGCAGAGTTGCTCAAGCATGTGGCGCAATCCAAGCTCAACTGACCAG
ACTGAACCGAGAGATACGAG

Downstream 100 bases:

>100_bases
CCGGGCGCCGCGGCTGCCATGACCCAGACGGGGGCCATCTGGCTGGTAATTTTGGCCGCCCTTGTGGCGGCCAATCTCCC
TTTCATCAATGACCGGTGGC

Product: NADH dehydrogenase subunit n

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MIDNISWLAIYPEIVLLVMACVIALVDLGVSSARRTGTYVLTMLTLAVVAALQAMYASSGNTFYAWGNMVVSDAMGNWLK
CFATVAVMVLLVYGRPYAADRDMLRGGELFTLTMLALLGMFVLISANNFLLIYLGLELLTLSSYALVALRRDNTTATEAA
MKYFVLGAMASGFLLYGLSMLYGATGSLDIGQVFKAINAGQIRHQVLVFGLVFVVAGLAFKMGVVPFHMWVPDVYQGAPT
AVTLFIGSAPKLAAFAMTIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIMQTNLKRMLAYSTISQMAFVLLGLMSG
VVHGNVDATAVENAYSSAMFYVVTYVLTTLAAFGVILLLAREGFESEEISDLAGLNQRSPLYAGVMAVCLFSMAGIPPLV
GFYAKLAVLQALVASGQVLHIALAVFAVMMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRVVLTINGALVLVLGLLP
GGLMALCADAIVRALAT

Sequences:

>Translated_497_residues
MIDNISWLAIYPEIVLLVMACVIALVDLGVSSARRTGTYVLTMLTLAVVAALQAMYASSGNTFYAWGNMVVSDAMGNWLK
CFATVAVMVLLVYGRPYAADRDMLRGGELFTLTMLALLGMFVLISANNFLLIYLGLELLTLSSYALVALRRDNTTATEAA
MKYFVLGAMASGFLLYGLSMLYGATGSLDIGQVFKAINAGQIRHQVLVFGLVFVVAGLAFKMGVVPFHMWVPDVYQGAPT
AVTLFIGSAPKLAAFAMTIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIMQTNLKRMLAYSTISQMAFVLLGLMSG
VVHGNVDATAVENAYSSAMFYVVTYVLTTLAAFGVILLLAREGFESEEISDLAGLNQRSPLYAGVMAVCLFSMAGIPPLV
GFYAKLAVLQALVASGQVLHIALAVFAVMMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRVVLTINGALVLVLGLLP
GGLMALCADAIVRALAT
>Mature_497_residues
MIDNISWLAIYPEIVLLVMACVIALVDLGVSSARRTGTYVLTMLTLAVVAALQAMYASSGNTFYAWGNMVVSDAMGNWLK
CFATVAVMVLLVYGRPYAADRDMLRGGELFTLTMLALLGMFVLISANNFLLIYLGLELLTLSSYALVALRRDNTTATEAA
MKYFVLGAMASGFLLYGLSMLYGATGSLDIGQVFKAINAGQIRHQVLVFGLVFVVAGLAFKMGVVPFHMWVPDVYQGAPT
AVTLFIGSAPKLAAFAMTIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIMQTNLKRMLAYSTISQMAFVLLGLMSG
VVHGNVDATAVENAYSSAMFYVVTYVLTTLAAFGVILLLAREGFESEEISDLAGLNQRSPLYAGVMAVCLFSMAGIPPLV
GFYAKLAVLQALVASGQVLHIALAVFAVMMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRVVLTINGALVLVLGLLP
GGLMALCADAIVRALAT

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=326, Percent_Identity=24.2331288343558, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI145693160, Length=399, Percent_Identity=34.8370927318296, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788614, Length=396, Percent_Identity=28.2828282828283, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1788827, Length=373, Percent_Identity=28.4182305630027, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788831, Length=336, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI2367154, Length=318, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788613, Length=321, Percent_Identity=25.2336448598131, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788829, Length=394, Percent_Identity=23.6040609137056, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52919; Mature: 52919

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDNISWLAIYPEIVLLVMACVIALVDLGVSSARRTGTYVLTMLTLAVVAALQAMYASSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NTFYAWGNMVVSDAMGNWLKCFATVAVMVLLVYGRPYAADRDMLRGGELFTLTMLALLGM
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHH
FVLISANNFLLIYLGLELLTLSSYALVALRRDNTTATEAAMKYFVLGAMASGFLLYGLSM
HHHHCCCCEEEEEEHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGATGSLDIGQVFKAINAGQIRHQVLVFGLVFVVAGLAFKMGVVPFHMWVPDVYQGAPT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHCCCCC
AVTLFIGSAPKLAAFAMTIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIMQTNLKR
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLAYSTISQMAFVLLGLMSGVVHGNVDATAVENAYSSAMFYVVTYVLTTLAAFGVILLLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REGFESEEISDLAGLNQRSPLYAGVMAVCLFSMAGIPPLVGFYAKLAVLQALVASGQVLH
HCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHH
IALAVFAVMMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRVVLTINGALVLVLGLLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHCC
GGLMALCADAIVRALAT
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDNISWLAIYPEIVLLVMACVIALVDLGVSSARRTGTYVLTMLTLAVVAALQAMYASSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NTFYAWGNMVVSDAMGNWLKCFATVAVMVLLVYGRPYAADRDMLRGGELFTLTMLALLGM
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHH
FVLISANNFLLIYLGLELLTLSSYALVALRRDNTTATEAAMKYFVLGAMASGFLLYGLSM
HHHHCCCCEEEEEEHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGATGSLDIGQVFKAINAGQIRHQVLVFGLVFVVAGLAFKMGVVPFHMWVPDVYQGAPT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHCCCCC
AVTLFIGSAPKLAAFAMTIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIMQTNLKR
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLAYSTISQMAFVLLGLMSGVVHGNVDATAVENAYSSAMFYVVTYVLTTLAAFGVILLLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REGFESEEISDLAGLNQRSPLYAGVMAVCLFSMAGIPPLVGFYAKLAVLQALVASGQVLH
HCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHH
IALAVFAVMMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRVVLTINGALVLVLGLLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHCC
GGLMALCADAIVRALAT
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA