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The map label for this gene is nuoD [H]

Identifier: 222110089

GI number: 222110089

Start: 898104

End: 899357

Strand: Direct

Name: nuoD [H]

Synonym: Dtpsy_0875

Alternate gene names: 222110089

Gene position: 898104-899357 (Clockwise)

Preceding gene: 222110088

Following gene: 222110090

Centisome position: 23.66

GC content: 61.24

Gene sequence:

>1254_bases
ATGGCTGAAATCAAGAACTACTCCCTGAACTTCGGACCGCAGCACCCGGCAGCACACGGCGTGCTGCGCTTGGTGCTGGA
ACTGGATGGCGAGGTCGTACAACGGGCCGACCCGCACATCGGGCTGTTGCACCGTGCCACCGAAAAGCTGGCAGAGCACA
AGACCTACATCCAGTCCTTGCCCTACATGGACCGTCTCGATTACGTGTCCATGATGTGCAACGAGCAGGCCTACTGCTTG
GCCATCGAGAAGATGCTGGGCATCGAGGTGCCACTGCGCGCGAAGTACATCCGAACGATGTTCGGCGAAATCACGCGCCT
GCTGAACCACCTGATGTGGCTGGGTTCGCACGGTAACGACTGCGGCAGCTCCACGATCCTCATCTATACCTTCCGTGAGC
GGGAGGACTTGTTCGACATGTACGAGGCCGTTTCTGGCGCTCGCATGCACGCGGCCTACTTCCGTCCGGGAGGCGTGTAC
CGGGACCTGCCGGACAGCATGGCCCAGTACAAGGTCAGCAAGATCAAGAACGCCAAGGCTATCGAGGAGCTCAACCGTAA
CCGCCAGGGTTCGCTGCTGGATTTCATCGACGATTTCACGCAGCGCTTCCCCAAGTGCGTAGACGAGTATGAGACCCTGC
TGACAGACAACCGGATCTGGAAGCAGCGTACGGTGGGTATCGGCGTGGTGCCGGCTGAGCGCGCGTTGAACCTGGGCATG
ACCGGCCCGATGCTGCGCGGCTCGGGCATTGCATGGGACCTGCGCAAGAAGCAACCCTACGACGCCTATGACCGCGTGGA
CTTCGATGTGCCGGTCGGGGTCACGGGCGATAGCTATGACCGCTATCTCGTTCGCGTGCAAGAGATGCGCGAGTCCAATC
GCATCATCAAGCAGTGCGTCGATTGGCTCAGGGCCAACCCCGGCCCCGTCATCACGGACAACCACAAGATCGCGCCGCCC
TCGCGCGAGGCCATGAAGTCCAACATGGAAGAGCTGATCCACCATTTCAAGCTCTTCACGGAAGGCTTCCGCGTGCCGGC
GGGCGAGGCTTACGCGGCCGTTGAGCACCCCAAGGGGGAGTTCGGTATCTACATGGTGAGCGACGGTGCGAACAAGCCCT
ACCGCCTGAAGATCCGCGCACCCGGGTTCGCGCATCTGGCCACACTCGACGAAATGGCGCGGGGCCACATGCTGGCCGAC
GCCGTGGCCATCATCGGCACCATGGATATCGTGTTCGGAGAGATTGACCGATGA

Upstream 100 bases:

>100_bases
AGCCCGTGACCATCGAGCCGCGCGAAGTGACGCCGCGCATCATCCGCGAAGACAAGTACGGAGGCCTGCACTGAGGCGGC
ATGCCGCTTGGTGATCGACC

Downstream 100 bases:

>100_bases
TTACCGAAGCGACCAAGCAACGTTTTGCCCGCGAAGTGGCGAAATACCCCGCAGACCAGAAACAGTCGGCGGTGATGGCG
TGCCTGTCCATCGTCCAGCA

Product: NADH dehydrogenase subunit d

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTYIQSLPYMDRLDYVSMMCNEQAYCL
AIEKMLGIEVPLRAKYIRTMFGEITRLLNHLMWLGSHGNDCGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVY
RDLPDSMAQYKVSKIKNAKAIEELNRNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVGIGVVPAERALNLGM
TGPMLRGSGIAWDLRKKQPYDAYDRVDFDVPVGVTGDSYDRYLVRVQEMRESNRIIKQCVDWLRANPGPVITDNHKIAPP
SREAMKSNMEELIHHFKLFTEGFRVPAGEAYAAVEHPKGEFGIYMVSDGANKPYRLKIRAPGFAHLATLDEMARGHMLAD
AVAIIGTMDIVFGEIDR

Sequences:

>Translated_417_residues
MAEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTYIQSLPYMDRLDYVSMMCNEQAYCL
AIEKMLGIEVPLRAKYIRTMFGEITRLLNHLMWLGSHGNDCGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVY
RDLPDSMAQYKVSKIKNAKAIEELNRNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVGIGVVPAERALNLGM
TGPMLRGSGIAWDLRKKQPYDAYDRVDFDVPVGVTGDSYDRYLVRVQEMRESNRIIKQCVDWLRANPGPVITDNHKIAPP
SREAMKSNMEELIHHFKLFTEGFRVPAGEAYAAVEHPKGEFGIYMVSDGANKPYRLKIRAPGFAHLATLDEMARGHMLAD
AVAIIGTMDIVFGEIDR
>Mature_416_residues
AEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTYIQSLPYMDRLDYVSMMCNEQAYCLA
IEKMLGIEVPLRAKYIRTMFGEITRLLNHLMWLGSHGNDCGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVYR
DLPDSMAQYKVSKIKNAKAIEELNRNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVGIGVVPAERALNLGMT
GPMLRGSGIAWDLRKKQPYDAYDRVDFDVPVGVTGDSYDRYLVRVQEMRESNRIIKQCVDWLRANPGPVITDNHKIAPPS
REAMKSNMEELIHHFKLFTEGFRVPAGEAYAAVEHPKGEFGIYMVSDGANKPYRLKIRAPGFAHLATLDEMARGHMLADA
VAIIGTMDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=61.8357487922705, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=61.2745098039216, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=37.0731707317073, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1789076, Length=420, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=27.4509803921569, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17555284, Length=414, Percent_Identity=58.695652173913, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17568379, Length=414, Percent_Identity=57.9710144927536, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24638644, Length=414, Percent_Identity=62.0772946859903, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221459469, Length=409, Percent_Identity=59.1687041564792, Blast_Score=496, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47436; Mature: 47305

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTYIQSL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMCNEQAYCLAIEKMLGIEVPLRAKYIRTMFGEITRLLNHLMWLGSHGND
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
CGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVYRDLPDSMAQYKVSKIKNAKA
CCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCHHH
IEELNRNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVGIGVVPAERALNLGM
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEECCHHHHHCCCC
TGPMLRGSGIAWDLRKKQPYDAYDRVDFDVPVGVTGDSYDRYLVRVQEMRESNRIIKQCV
CCCCCCCCCCEEECCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DWLRANPGPVITDNHKIAPPSREAMKSNMEELIHHFKLFTEGFRVPAGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
FGIYMVSDGANKPYRLKIRAPGFAHLATLDEMARGHMLADAVAIIGTMDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTYIQSL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMCNEQAYCLAIEKMLGIEVPLRAKYIRTMFGEITRLLNHLMWLGSHGND
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
CGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVYRDLPDSMAQYKVSKIKNAKA
CCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCHHH
IEELNRNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVGIGVVPAERALNLGM
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEECCHHHHHCCCC
TGPMLRGSGIAWDLRKKQPYDAYDRVDFDVPVGVTGDSYDRYLVRVQEMRESNRIIKQCV
CCCCCCCCCCEEECCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DWLRANPGPVITDNHKIAPPSREAMKSNMEELIHHFKLFTEGFRVPAGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
FGIYMVSDGANKPYRLKIRAPGFAHLATLDEMARGHMLADAVAIIGTMDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA