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The map label for this gene is mutY [H]

Identifier: 222110044

GI number: 222110044

Start: 861990

End: 863063

Strand: Direct

Name: mutY [H]

Synonym: Dtpsy_0830

Alternate gene names: 222110044

Gene position: 861990-863063 (Clockwise)

Preceding gene: 222110043

Following gene: 222110049

Centisome position: 22.7

GC content: 70.48

Gene sequence:

>1074_bases
ATGAGCGGTCCGTCCGCAGAGCTGGCGACCCAGGTGGTGCGCTGGCAGGCAGCGCATGGGCGCAACCACCTGCCTTGGCA
GAACACGCGCGATGCATACCGCGTGTGGCTGTCGGAGATCATGCTGCAGCAGACCCAGGTGGCCACGGTGCTGGAGTACT
ACACGCGCTTTCTGGCGCGCTTTCCCGACGTGCGCCAACTGGCTGCTGCGCCGCAAGACGAGGTACTGGCGCTGTGGAGC
GGCCTGGGTTACTACAGCCGCGCGCGCAACCTGCACCGCTGCGCGCAGATCGTCGTGCACCAGCACGGGGGGGAATTCCC
CCGCACGGTGGATGAGCTGGCGGCCTTGCCGGGCATCGGCCGCTCCACGGCAGGGGCGATAGCCGCTTTCTGCTTCGGCG
TACGGGCGCCGATCCTGGATGCCAACGTGCGGCGCGTGCTCACGCGGGTGCTGGGGTTCGGCGCCGACCTGGCCGAGGCG
AAGAACGAGCGCGCGCTATGGCAGCAGGCCGAGGCGCTGCTGCCACGGCAGGACCTGTCCCATGCCATGCCGCGCTACAC
GCAGGGCCTGATGGACCTGGGCGCCGGCATCTGCCTGCCCCGCAACCCCAATTGCCTGCTGTGCCCCTTGCAAGAGGCCT
GCGTGGCGCGCCGCGACGGCAACCCGCAGGACTACCCGGTGCGCACGCGCAAGCTCAAGCGCAGCGCGCAGGCCTGGTGG
CTGCTGCTGCGCCAGGATGGTGCTGGCCGGCTGTGGCTGGAGCGGCGTCCGCCCACCGGCATCTGGGCGGGGCTGTACTG
TCCGCCGGTCTATGACAGCCGCGCGGCGCTGGACGAGGCGCTGCAGCTGCACGCCAGCTGCGATGCGCGGGATCTGCCGG
CCTTCACCCACGTGCTGACGCACCGCGACCTGCACCTGCATCCGGTGCTGGCGCGCGATGCAACGCCGCAGCCGGATGCG
CATTGCGCTGAGCAGCAGTCGGGGTGGTTCGCTCCGGTGCAATGGCCGGCGCTGGGGCTGCCCGCGCCCGTGCGCAAGCT
GCTCGCCTCCCTTGGGGACGACTGTCAAAAATGA

Upstream 100 bases:

>100_bases
GGCTGACCGAGCTGACCTCCGACCTCGTGCGGCAGCCGCAAGCGCCTGAGGGCGTGGACATCGACATACCCCTTACCGAA
CCCCAGCCGCTCGCGGCGTC

Downstream 100 bases:

>100_bases
GAGCTGGTAGCGCCCGTAGATAGGCGACTTCCGGTAGAAAACTATTGCAAATCGTTCAATAGCAAGCGCTAGCAGCTACT
AAAACAATAGCTGTCACCTA

Product: a/g-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSGPSAELATQVVRWQAAHGRNHLPWQNTRDAYRVWLSEIMLQQTQVATVLEYYTRFLARFPDVRQLAAAPQDEVLALWS
GLGYYSRARNLHRCAQIVVHQHGGEFPRTVDELAALPGIGRSTAGAIAAFCFGVRAPILDANVRRVLTRVLGFGADLAEA
KNERALWQQAEALLPRQDLSHAMPRYTQGLMDLGAGICLPRNPNCLLCPLQEACVARRDGNPQDYPVRTRKLKRSAQAWW
LLLRQDGAGRLWLERRPPTGIWAGLYCPPVYDSRAALDEALQLHASCDARDLPAFTHVLTHRDLHLHPVLARDATPQPDA
HCAEQQSGWFAPVQWPALGLPAPVRKLLASLGDDCQK

Sequences:

>Translated_357_residues
MSGPSAELATQVVRWQAAHGRNHLPWQNTRDAYRVWLSEIMLQQTQVATVLEYYTRFLARFPDVRQLAAAPQDEVLALWS
GLGYYSRARNLHRCAQIVVHQHGGEFPRTVDELAALPGIGRSTAGAIAAFCFGVRAPILDANVRRVLTRVLGFGADLAEA
KNERALWQQAEALLPRQDLSHAMPRYTQGLMDLGAGICLPRNPNCLLCPLQEACVARRDGNPQDYPVRTRKLKRSAQAWW
LLLRQDGAGRLWLERRPPTGIWAGLYCPPVYDSRAALDEALQLHASCDARDLPAFTHVLTHRDLHLHPVLARDATPQPDA
HCAEQQSGWFAPVQWPALGLPAPVRKLLASLGDDCQK
>Mature_356_residues
SGPSAELATQVVRWQAAHGRNHLPWQNTRDAYRVWLSEIMLQQTQVATVLEYYTRFLARFPDVRQLAAAPQDEVLALWSG
LGYYSRARNLHRCAQIVVHQHGGEFPRTVDELAALPGIGRSTAGAIAAFCFGVRAPILDANVRRVLTRVLGFGADLAEAK
NERALWQQAEALLPRQDLSHAMPRYTQGLMDLGAGICLPRNPNCLLCPLQEACVARRDGNPQDYPVRTRKLKRSAQAWWL
LLRQDGAGRLWLERRPPTGIWAGLYCPPVYDSRAALDEALQLHASCDARDLPAFTHVLTHRDLHLHPVLARDATPQPDAH
CAEQQSGWFAPVQWPALGLPAPVRKLLASLGDDCQK

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=208, Percent_Identity=44.7115384615385, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI115298652, Length=208, Percent_Identity=44.7115384615385, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI6912520, Length=208, Percent_Identity=44.7115384615385, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI115298650, Length=208, Percent_Identity=44.7115384615385, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI115298648, Length=208, Percent_Identity=44.7115384615385, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI190358497, Length=208, Percent_Identity=44.7115384615385, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1789331, Length=350, Percent_Identity=42.8571428571429, Blast_Score=274, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39807; Mature: 39676

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPSAELATQVVRWQAAHGRNHLPWQNTRDAYRVWLSEIMLQQTQVATVLEYYTRFLAR
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPDVRQLAAAPQDEVLALWSGLGYYSRARNLHRCAQIVVHQHGGEFPRTVDELAALPGIG
CCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
RSTAGAIAAFCFGVRAPILDANVRRVLTRVLGFGADLAEAKNERALWQQAEALLPRQDLS
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHH
HAMPRYTQGLMDLGAGICLPRNPNCLLCPLQEACVARRDGNPQDYPVRTRKLKRSAQAWW
HHHHHHHHHHHHHCCCEECCCCCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHE
LLLRQDGAGRLWLERRPPTGIWAGLYCPPVYDSRAALDEALQLHASCDARDLPAFTHVLT
EEEEECCCCCEEEECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
HRDLHLHPVLARDATPQPDAHCAEQQSGWFAPVQWPALGLPAPVRKLLASLGDDCQK
CCCCCCCEEHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCHHCCC
>Mature Secondary Structure 
SGPSAELATQVVRWQAAHGRNHLPWQNTRDAYRVWLSEIMLQQTQVATVLEYYTRFLAR
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPDVRQLAAAPQDEVLALWSGLGYYSRARNLHRCAQIVVHQHGGEFPRTVDELAALPGIG
CCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
RSTAGAIAAFCFGVRAPILDANVRRVLTRVLGFGADLAEAKNERALWQQAEALLPRQDLS
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHH
HAMPRYTQGLMDLGAGICLPRNPNCLLCPLQEACVARRDGNPQDYPVRTRKLKRSAQAWW
HHHHHHHHHHHHHCCCEECCCCCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHE
LLLRQDGAGRLWLERRPPTGIWAGLYCPPVYDSRAALDEALQLHASCDARDLPAFTHVLT
EEEEECCCCCEEEECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
HRDLHLHPVLARDATPQPDAHCAEQQSGWFAPVQWPALGLPAPVRKLLASLGDDCQK
CCCCCCCEEHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]