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The map label for this gene is ubiB

Identifier: 222110014

GI number: 222110014

Start: 830925

End: 832490

Strand: Direct

Name: ubiB

Synonym: Dtpsy_0799

Alternate gene names: 222110014

Gene position: 830925-832490 (Clockwise)

Preceding gene: 222110013

Following gene: 222110015

Centisome position: 21.89

GC content: 65.39

Gene sequence:

>1566_bases
ATGAGCCGCTTTGCCCGCGGCATCACCATCGTCTGGGTGGTGCTGCGCTATGGACTCGACGAACTGGTGCTGTCGACCTT
CCGGCAGCCGTGGCTGCGCGCCGTCACGCGGGTCATCACCTTCGGTCGCAAGCTGGACGCGCCGCGCGGCCAGCGGCTGC
GCGAGGCCTTGGAGAGCCTGGGTCCGATTTTCGTGAAGTTCGGGCAGGTCCTGTCCACGCGCCGCGACCTCATGCCGCCG
GACATTGCGGACGAGCTGGCGCTGCTGCAGGATCGCGTGCCGCCGTTCGACCCCGATGTGGCGATCGCCACCATCGAGCG
CGCATTTCGCCGCCCGATCGGCGAGGTGTTCGTCTCGTTCGACCGACAGCCCGTGGCCAGCGCGTCCATCGCACAGGTGC
ACTTCGCGGTGATCCGTGACCGCCAAGGGCACGCGCGTGAAGTCGCCGTGAAGGTGCTGCGCCCCGGCATGCTGCCGGTG
ATCGACAAGGATTTGGCGCTCATGCGCATGATGGCCGGGTGGGTGGAAAGCCTGTCCGCCGACGGCAAGCGCCTCAAGCC
CCGCGAGGTCGTGGCCGAGTTCGACAACTACCTGCACGACGAACTCGACCTGGTGCGCGAGGCGGCCAACGCGGCGCAGC
TGCGCCGCAACATGCAGGGGCTGGACTTGGTGCTCATCCCGGAGGTGTTCTGGGATTTCTGCCATGCCGAAGTGTTGGTG
ATGGAGCGCATGAAGGGCGTGCCCATCAACCAGGTGGAGCGCCTGCGCAGCGCGGGCGTGGACATTCCCAAGCTGGCCCG
CGACGGCGTGACCATCTTCTTCACCCAGGTGTTCCGCGACGGGTTCTTTCATGCCGACATGCATCCCGGCAACATCCAGG
TGAGCCTGGCGCCCGAGACCTTCGGCCGCTACATCTCGCTGGACTTTGGCATCGTCGGGACGCTGACCGAGTTCGACAAG
GAATACCTTGCGCAGAACTTCACGGCTTTTTTCAGGCGCGACTACAAGCGCGTGGCCGAACTGCACATCGAAAGCGGCTG
GGTTCCCGCCCATACCCGCGTGAACGAACTGGAAGCCGCTATCCGCACCGTGTGCGAGCCGTATTTCGACCGGCCGCTCA
AGGAAATCTCTTTGGGCATGGTGCTGCTGCGGCTGTTCCAGACCTCGCGGCGCTTCCAGGTGGAGATCCAGCCGCAGCTG
GTGCTGCTGCAAAAAACCTTGCTCAACATCGAAGGGCTGGGCCGGCAGTTGGACCCCGACCTGGACCTGTGGAGCACGGC
CAAGCCCTTCCTGGAGAAGTGGATGCTCGATCAGCTGGGTCCCCAACGCCTGTGGCGCGAGCTGCGTGCCGAGGCGCCGC
ACTACGCCAAGATCCTGCCCGACCTGCCACGCCTGCTCCACGACTTCCTGCGCCAGCGGCCCCATGACAACCGGGGCGAT
CTGCAGGAACTGCTGGCCACCCAGAAGCGCACCAACCGGCTGCTGCAAAGCATCATCTATGGCGGCCTGGGCTTCGTGCT
GGGGCTGCTGGTCATGCAGCTCTTCGTGCGCGTGCGCATCTTCTAA

Upstream 100 bases:

>100_bases
GACGCGCCGTGCAGGCGTTGCGCAGCTTCGTGGGCGCACGCGTGCCCGGCGGCCAGGCGCCCGCGCCCGCAGCGGGCGAG
TTGCCGGACCGCTCCCCGCC

Downstream 100 bases:

>100_bases
CTTCCTTCCCTCTCTCATTCCTCAGGAGTACCAGCGTGTTGCTCTTCATGGTGATTGCCTACCTGTTTGTCACCATCGGC
ATTGGCTTGTGGGCTGCCCA

Product: ubiquinone biosynthesis protein ubib

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MSRFARGITIVWVVLRYGLDELVLSTFRQPWLRAVTRVITFGRKLDAPRGQRLREALESLGPIFVKFGQVLSTRRDLMPP
DIADELALLQDRVPPFDPDVAIATIERAFRRPIGEVFVSFDRQPVASASIAQVHFAVIRDRQGHAREVAVKVLRPGMLPV
IDKDLALMRMMAGWVESLSADGKRLKPREVVAEFDNYLHDELDLVREAANAAQLRRNMQGLDLVLIPEVFWDFCHAEVLV
MERMKGVPINQVERLRSAGVDIPKLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLAPETFGRYISLDFGIVGTLTEFDK
EYLAQNFTAFFRRDYKRVAELHIESGWVPAHTRVNELEAAIRTVCEPYFDRPLKEISLGMVLLRLFQTSRRFQVEIQPQL
VLLQKTLLNIEGLGRQLDPDLDLWSTAKPFLEKWMLDQLGPQRLWRELRAEAPHYAKILPDLPRLLHDFLRQRPHDNRGD
LQELLATQKRTNRLLQSIIYGGLGFVLGLLVMQLFVRVRIF

Sequences:

>Translated_521_residues
MSRFARGITIVWVVLRYGLDELVLSTFRQPWLRAVTRVITFGRKLDAPRGQRLREALESLGPIFVKFGQVLSTRRDLMPP
DIADELALLQDRVPPFDPDVAIATIERAFRRPIGEVFVSFDRQPVASASIAQVHFAVIRDRQGHAREVAVKVLRPGMLPV
IDKDLALMRMMAGWVESLSADGKRLKPREVVAEFDNYLHDELDLVREAANAAQLRRNMQGLDLVLIPEVFWDFCHAEVLV
MERMKGVPINQVERLRSAGVDIPKLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLAPETFGRYISLDFGIVGTLTEFDK
EYLAQNFTAFFRRDYKRVAELHIESGWVPAHTRVNELEAAIRTVCEPYFDRPLKEISLGMVLLRLFQTSRRFQVEIQPQL
VLLQKTLLNIEGLGRQLDPDLDLWSTAKPFLEKWMLDQLGPQRLWRELRAEAPHYAKILPDLPRLLHDFLRQRPHDNRGD
LQELLATQKRTNRLLQSIIYGGLGFVLGLLVMQLFVRVRIF
>Mature_520_residues
SRFARGITIVWVVLRYGLDELVLSTFRQPWLRAVTRVITFGRKLDAPRGQRLREALESLGPIFVKFGQVLSTRRDLMPPD
IADELALLQDRVPPFDPDVAIATIERAFRRPIGEVFVSFDRQPVASASIAQVHFAVIRDRQGHAREVAVKVLRPGMLPVI
DKDLALMRMMAGWVESLSADGKRLKPREVVAEFDNYLHDELDLVREAANAAQLRRNMQGLDLVLIPEVFWDFCHAEVLVM
ERMKGVPINQVERLRSAGVDIPKLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLAPETFGRYISLDFGIVGTLTEFDKE
YLAQNFTAFFRRDYKRVAELHIESGWVPAHTRVNELEAAIRTVCEPYFDRPLKEISLGMVLLRLFQTSRRFQVEIQPQLV
LLQKTLLNIEGLGRQLDPDLDLWSTAKPFLEKWMLDQLGPQRLWRELRAEAPHYAKILPDLPRLLHDFLRQRPHDNRGDL
QELLATQKRTNRLLQSIIYGGLGFVLGLLVMQLFVRVRIF

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily

Homologues:

Organism=Homo sapiens, GI41393593, Length=276, Percent_Identity=31.5217391304348, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI40254938, Length=292, Percent_Identity=29.4520547945205, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI217035081, Length=233, Percent_Identity=31.3304721030043, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI32261307, Length=322, Percent_Identity=28.8819875776398, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI34147522, Length=199, Percent_Identity=28.643216080402, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI2367309, Length=504, Percent_Identity=51.984126984127, Blast_Score=481, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17559152, Length=304, Percent_Identity=24.0131578947368, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=316, Percent_Identity=27.5316455696203, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=437, Percent_Identity=24.9427917620137, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323282, Length=259, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI22024280, Length=255, Percent_Identity=27.4509803921569, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24662575, Length=287, Percent_Identity=28.5714285714286, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIB_ACIET (B9ME24)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552278.1
- GeneID:   7383739
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0799
- ProtClustDB:   PRK04750
- HAMAP:   MF_00414
- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232
- TIGRFAMs:   TIGR01982

Pfam domain/function: PF03109 ABC1; SSF56112 Kinase_like

EC number: NA

Molecular weight: Translated: 59956; Mature: 59825

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x22fb0008)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SRFARGITIVWVVLRYGLDELVLSTFRQPWLRAVTRVITFGRKLDAPRGQRLREALESL
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GPIFVKFGQVLSTRRDLMPPDIADELALLQDRVPPFDPDVAIATIERAFRRPIGEVFVSF
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHC
DRQPVASASIAQVHFAVIRDRQGHAREVAVKVLRPGMLPVIDKDLALMRMMAGWVESLSA
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
DGKRLKPREVVAEFDNYLHDELDLVREAANAAQLRRNMQGLDLVLIPEVFWDFCHAEVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHH
MERMKGVPINQVERLRSAGVDIPKLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLAPET
HHHHCCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEEECHHH
FGRYISLDFGIVGTLTEFDKEYLAQNFTAFFRRDYKRVAELHIESGWVPAHTRVNELEAA
HCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRTVCEPYFDRPLKEISLGMVLLRLFQTSRRFQVEIQPQLVLLQKTLLNIEGLGRQLDPD
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
LDLWSTAKPFLEKWMLDQLGPQRLWRELRAEAPHYAKILPDLPRLLHDFLRQRPHDNRGD
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
LQELLATQKRTNRLLQSIIYGGLGFVLGLLVMQLFVRVRIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA