Click here to switch to the map view.

The map label for this gene is hisE

Identifier: 222109955

GI number: 222109955

Start: 771312

End: 771710

Strand: Direct

Name: hisE

Synonym: Dtpsy_0740

Alternate gene names: 222109955

Gene position: 771312-771710 (Clockwise)

Preceding gene: 222109954

Following gene: 222109956

Centisome position: 20.32

GC content: 67.42

Gene sequence:

>399_bases
ATGACCCGCACCGATACCCATGCCCCTCTGTCGCAGGACGCGCTTGCGCGGCTGGCCGGCGTCATCGAAAGCCGCAAGCC
CGCCAACGGCGGCGACCCTGACAAGAGCTACGTCGCGCGACTGCTGCACAAGGGGCCTGACGCCTTCCTCAAGAAGGTGG
GCGAGGAGGCGACAGAGGTGGTCATGGCGGCCAAGGACTTGGACCATGGCGCCGACAAGGCCAAGCTGGTGTACGAGGTG
GCCGACCTGTGGTTCCACTCGATGATCGCGCTGGCGCACTACGGGCTTGCCCCCGCCGACGTGATTGCCGAGCTGGAGCG
CCGCGAGGGCATCAGCGGCATCGAGGAAAAGGCCCTGCGCAAGGCCGCAGCCCGCAGCAGCGAAGAAGGAGGTGCGTGA

Upstream 100 bases:

>100_bases
GGGCCGTCACAGCTGCTTCTTCAACGCCCTCCAGAATGGCGCGTGGCAGGCTGTCGATCCGGTCTTGAAAGACCCCGAAT
CCATCTACAAATAAAAAGCC

Downstream 100 bases:

>100_bases
TGAACAACGATATCGTCGACGTGGAGCCCAGCGAGCGGGCCGAATCCCTCAAGACGGTCGGATGGGTCAGCTACATCCTG
CACCTGATCGTGGCCGTGGC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MTRTDTHAPLSQDALARLAGVIESRKPANGGDPDKSYVARLLHKGPDAFLKKVGEEATEVVMAAKDLDHGADKAKLVYEV
ADLWFHSMIALAHYGLAPADVIAELERREGISGIEEKALRKAAARSSEEGGA

Sequences:

>Translated_132_residues
MTRTDTHAPLSQDALARLAGVIESRKPANGGDPDKSYVARLLHKGPDAFLKKVGEEATEVVMAAKDLDHGADKAKLVYEV
ADLWFHSMIALAHYGLAPADVIAELERREGISGIEEKALRKAAARSSEEGGA
>Mature_131_residues
TRTDTHAPLSQDALARLAGVIESRKPANGGDPDKSYVARLLHKGPDAFLKKVGEEATEVVMAAKDLDHGADKAKLVYEVA
DLWFHSMIALAHYGLAPADVIAELERREGISGIEEKALRKAAARSSEEGGA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_ACISJ (A1W446)

Other databases:

- EMBL:   CP000539
- RefSeq:   YP_985097.1
- ProteinModelPortal:   A1W446
- SMR:   A1W446
- STRING:   A1W446
- GeneID:   4673887
- GenomeReviews:   CP000539_GR
- KEGG:   ajs:Ajs_0777
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   ASP232721:AJS_0777-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 14133; Mature: 14002

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTDTHAPLSQDALARLAGVIESRKPANGGDPDKSYVARLLHKGPDAFLKKVGEEATEV
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
VMAAKDLDHGADKAKLVYEVADLWFHSMIALAHYGLAPADVIAELERREGISGIEEKALR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHH
KAAARSSEEGGA
HHHHHCCCCCCC
>Mature Secondary Structure 
TRTDTHAPLSQDALARLAGVIESRKPANGGDPDKSYVARLLHKGPDAFLKKVGEEATEV
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
VMAAKDLDHGADKAKLVYEVADLWFHSMIALAHYGLAPADVIAELERREGISGIEEKALR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHH
KAAARSSEEGGA
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA