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The map label for this gene is hisI

Identifier: 222109954

GI number: 222109954

Start: 770907

End: 771305

Strand: Direct

Name: hisI

Synonym: Dtpsy_0739

Alternate gene names: 222109954

Gene position: 770907-771305 (Clockwise)

Preceding gene: 222109953

Following gene: 222109955

Centisome position: 20.31

GC content: 63.16

Gene sequence:

>399_bases
ATGGACACCATGAACTGGCTTGATCAACTGAAATGGGATGCGCAGGGCCTGGTGCCCGTCATTGCGCAGGAGGCGGCCAC
GGGCGACGTGCTGATGTTCGCCTGGATGAACCGCGAGGCGCTGGCCAAGACCGCCGAGCTGGGCCGCGCCGTGTACTACA
GCCGCTCGCGCGGCAAGCTGTGGTTCAAGGGCGAGGAGTCGGGCCATGTGCAGCAGGTGCATGACATTCGCCTGGACTGC
GACAGCGATGTGGTGCTGCTGAAGGTGACGCAGCTGGGCCACGAGCCCGGCATTGCCTGCCACACGGGCCGTCACAGCTG
CTTCTTCAACGCCCTCCAGAATGGCGCGTGGCAGGCTGTCGATCCGGTCTTGAAAGACCCCGAATCCATCTACAAATAA

Upstream 100 bases:

>100_bases
GTGAATGGATGCCGAAAAGGCCTGTAGCGCGCTTCCAGCAAGCGCTATAAGCTATAAAAAATGCAGCATACATCGGCGTT
GTAGCTGCCGATGACCGACA

Downstream 100 bases:

>100_bases
AAAGCCATGACCCGCACCGATACCCATGCCCCTCTGTCGCAGGACGCGCTTGCGCGGCTGGCCGGCGTCATCGAAAGCCG
CAAGCCCGCCAACGGCGGCG

Product: phosphoribosyl-amp cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MDTMNWLDQLKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYYSRSRGKLWFKGEESGHVQQVHDIRLDC
DSDVVLLKVTQLGHEPGIACHTGRHSCFFNALQNGAWQAVDPVLKDPESIYK

Sequences:

>Translated_132_residues
MDTMNWLDQLKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYYSRSRGKLWFKGEESGHVQQVHDIRLDC
DSDVVLLKVTQLGHEPGIACHTGRHSCFFNALQNGAWQAVDPVLKDPESIYK
>Mature_132_residues
MDTMNWLDQLKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYYSRSRGKLWFKGEESGHVQQVHDIRLDC
DSDVVLLKVTQLGHEPGIACHTGRHSCFFNALQNGAWQAVDPVLKDPESIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=101, Percent_Identity=45.5445544554455, Blast_Score=93, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319819, Length=78, Percent_Identity=43.5897435897436, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_ACIET (B9MDW4)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552218.1
- GeneID:   7383677
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0739
- ProtClustDB:   PRK00051
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14843; Mature: 14843

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTMNWLDQLKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYYSRSRGKL
CCHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHEEECCCCEE
WFKGEESGHVQQVHDIRLDCDSDVVLLKVTQLGHEPGIACHTGRHSCFFNALQNGAWQAV
EEECCCCCCCEEHEEEEECCCCCEEEEEEECCCCCCCCEEECCCHHHHHHHHHCCCCCHH
DPVLKDPESIYK
CHHHCCHHHHCC
>Mature Secondary Structure
MDTMNWLDQLKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYYSRSRGKL
CCHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHEEECCCCEE
WFKGEESGHVQQVHDIRLDCDSDVVLLKVTQLGHEPGIACHTGRHSCFFNALQNGAWQAV
EEECCCCCCCEEHEEEEECCCCCEEEEEEECCCCCCCCEEECCCHHHHHHHHHCCCCCHH
DPVLKDPESIYK
CHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA