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The map label for this gene is hisB

Identifier: 222109945

GI number: 222109945

Start: 760504

End: 761136

Strand: Direct

Name: hisB

Synonym: Dtpsy_0730

Alternate gene names: 222109945

Gene position: 760504-761136 (Clockwise)

Preceding gene: 222109944

Following gene: 222109946

Centisome position: 20.03

GC content: 66.67

Gene sequence:

>633_bases
ATGACTTCCTCCGCACTCGTTCCTTCTTCCGCAGAACTCTGCCCCGACCGCACGGCCGAGGTCAGCCGCACGACGGCCGA
GACGCGCATCACCGTGCGCGTGAATCTCGACGGCACCGGCGCGGCCAGCCTGCACACCGGCATCGGCTTCTTCGACCACA
TGCTCGACCAGATCGCGCGCCATGGGCTGATCGACCTGCAGATCGACTGCGACGGCGACCTGCACATCGACGGCCACCAC
ACGGTGGAAGATGTGGGCATCACGCTGGGCCAGGCTTTCGCGCGGGCCGTGGGCGACAAGAAGGGCATCCGCCGCTACGG
CCATGCCTACGTGCCGCTCGATGAAGCCCTGTCACGCGTGGTGGTGGACTTCTCGGGCCGCCCGGGGCTGCACCTGCACA
TTCCGTTCACCGCCGGGAGCATTGGCGGTTTCGACACCCAGCTCACCTACGAATTCTTCCAGGGCTTCGTGAACCATGCG
GGCGTTACGCTGCACATCGACAATCTGAAGGGCATCAACGCCCACCACCAGTGCGAGACGGTGTTCAAGGCCTTCGCGCG
CGCGCTGCGCGCCGCGCTGGAGCGCGACCCGCGCGCCGCAGGCGTGATCCCCTCCACCAAGGGTTCCCTGTAA

Upstream 100 bases:

>100_bases
ACGTTTCTACAATGCATCCATTGCTGGCAGGCTGCCTGCGTCTGACGGTGGGCAGCAGTGCCGACAACGCCCAGATGCTC
ACAGCGCTCCAGGCATCCCT

Downstream 100 bases:

>100_bases
AATTCAAGCCAAATTGGCCTGTAACGCTTATCCATCAAGCGCAAGCAGCTATGAATAGTGAAGCAAAAACCGTCGCGGTC
GTGGACTACGGCATGGGCAA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTSSALVPSSAELCPDRTAEVSRTTAETRITVRVNLDGTGAASLHTGIGFFDHMLDQIARHGLIDLQIDCDGDLHIDGHH
TVEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRVVVDFSGRPGLHLHIPFTAGSIGGFDTQLTYEFFQGFVNHA
GVTLHIDNLKGINAHHQCETVFKAFARALRAALERDPRAAGVIPSTKGSL

Sequences:

>Translated_210_residues
MTSSALVPSSAELCPDRTAEVSRTTAETRITVRVNLDGTGAASLHTGIGFFDHMLDQIARHGLIDLQIDCDGDLHIDGHH
TVEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRVVVDFSGRPGLHLHIPFTAGSIGGFDTQLTYEFFQGFVNHA
GVTLHIDNLKGINAHHQCETVFKAFARALRAALERDPRAAGVIPSTKGSL
>Mature_209_residues
TSSALVPSSAELCPDRTAEVSRTTAETRITVRVNLDGTGAASLHTGIGFFDHMLDQIARHGLIDLQIDCDGDLHIDGHHT
VEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRVVVDFSGRPGLHLHIPFTAGSIGGFDTQLTYEFFQGFVNHAG
VTLHIDNLKGINAHHQCETVFKAFARALRAALERDPRAAGVIPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=196, Percent_Identity=48.9795918367347, Blast_Score=180, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=219, Percent_Identity=39.2694063926941, Blast_Score=164, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_ACIET (B9MDV5)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552209.1
- ProteinModelPortal:   B9MDV5
- SMR:   B9MDV5
- GeneID:   7383668
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0730
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22591; Mature: 22460

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSALVPSSAELCPDRTAEVSRTTAETRITVRVNLDGTGAASLHTGIGFFDHMLDQIAR
CCCCCCCCCCHHCCCCCCHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
HGLIDLQIDCDGDLHIDGHHTVEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRV
CCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHH
VVDFSGRPGLHLHIPFTAGSIGGFDTQLTYEFFQGFVNHAGVTLHIDNLKGINAHHQCET
EEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
VFKAFARALRAALERDPRAAGVIPSTKGSL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSSALVPSSAELCPDRTAEVSRTTAETRITVRVNLDGTGAASLHTGIGFFDHMLDQIAR
CCCCCCCCCHHCCCCCCHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
HGLIDLQIDCDGDLHIDGHHTVEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRV
CCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHH
VVDFSGRPGLHLHIPFTAGSIGGFDTQLTYEFFQGFVNHAGVTLHIDNLKGINAHHQCET
EEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
VFKAFARALRAALERDPRAAGVIPSTKGSL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA