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The map label for this gene is hisC

Identifier: 222109944

GI number: 222109944

Start: 759401

End: 760507

Strand: Direct

Name: hisC

Synonym: Dtpsy_0729

Alternate gene names: 222109944

Gene position: 759401-760507 (Clockwise)

Preceding gene: 222109943

Following gene: 222109945

Centisome position: 20.0

GC content: 69.47

Gene sequence:

>1107_bases
ATGACAACCCCTTCTGCCGAACTGCCCGCGCTGGCGCGCATCCGCGACGACGTGCGGGCCATGCAGGCTTACGTCGTGGC
CGATGCGACCGGCTACCTGAAGATGGACGCGATGGAGAACCCCTTCGGCCTGCCGCCCGCGCTGCAGGCCGCGCTGGGGC
AGCGCCTGGGGCAACTCGCGCTCAACCGCTACCCCGGTACGCGCCAGAACGACCTGAAGGCTGCGCTGGCGGCCTACGCA
GGGGAGCCGGCAGGCTCGGCCGTGCTGCTGGGCAATGGTTCCGACGAGCTCATTTCCCTCGTGGCGCTGGCCTGCGCGCG
TGCGCAGGCGACCGTGCTGGCGCCCGTGCCGGGCTTCGTGATGTATGCGATGAGCGCGCAGCTGCAGGGCTTGGGCTTCG
TGGGCGTGCCGTTGACGGCGGACTTCGAGCTGGACGAGGCCGCGATGCTGGACGCGATCGCCCAGCACCGCCCGGCCATC
ACCTTCCTGGCCTATCCCAACAACCCCACGGCCACGCTGTGGGACGAGGCCGTGGTGCAGCGCATCATCGACGCCGCCGG
TGCGCAGGGCGGCATCGTGGTCATGGACGAGGCCTACCAGCCCTTTGCCAGCCGCAGCTGGATCGAGCGCATGCGCGCGC
AGCCCGAGCGCAACGGCCATGTGCTGCTGATGCGCACGCTCTCCAAGTTCGGCCTGGCCGGCGTGCGCCTGGGCTACATG
ATCGGCCCCGCCGCGCTGGTGGCCGAGGTCGACAAGGTGCGCCCGCCGTACAACGTGAGTGTGCTCAACACCGAGGCCGC
CCTGTTCGCGCTGGAACATGCCGACGTGTTCGCCGCCCAGGCCGACGAGCTGCGTGCCGCGCGCACCGAGCTGCTGGCCG
CGCTGCGCGCCATGCCCGGCATTGAGCGCGTGTGGGACAGCCAGGCCAACATGGTGCTGGTGCGTGTGCCCGATGCCGCC
CGCGCCTATGAGGGCATGAAGGCCCGCAAGGTGCTCGTCAAGAACGTTTCTACAATGCATCCATTGCTGGCAGGCTGCCT
GCGTCTGACGGTGGGCAGCAGTGCCGACAACGCCCAGATGCTCACAGCGCTCCAGGCATCCCTATGA

Upstream 100 bases:

>100_bases
GCGCGCAGTACGGCGGCGTAGAGGTGCTGCATCCGCTGCATTGCGCGTTGGCTGTCCCCTGATGTGGCGGCGCCGCCCGA
TCGAATGGAGTGATGAACGC

Downstream 100 bases:

>100_bases
CTTCCTCCGCACTCGTTCCTTCTTCCGCAGAACTCTGCCCCGACCGCACGGCCGAGGTCAGCCGCACGACGGCCGAGACG
CGCATCACCGTGCGCGTGAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MTTPSAELPALARIRDDVRAMQAYVVADATGYLKMDAMENPFGLPPALQAALGQRLGQLALNRYPGTRQNDLKAALAAYA
GEPAGSAVLLGNGSDELISLVALACARAQATVLAPVPGFVMYAMSAQLQGLGFVGVPLTADFELDEAAMLDAIAQHRPAI
TFLAYPNNPTATLWDEAVVQRIIDAAGAQGGIVVMDEAYQPFASRSWIERMRAQPERNGHVLLMRTLSKFGLAGVRLGYM
IGPAALVAEVDKVRPPYNVSVLNTEAALFALEHADVFAAQADELRAARTELLAALRAMPGIERVWDSQANMVLVRVPDAA
RAYEGMKARKVLVKNVSTMHPLLAGCLRLTVGSSADNAQMLTALQASL

Sequences:

>Translated_368_residues
MTTPSAELPALARIRDDVRAMQAYVVADATGYLKMDAMENPFGLPPALQAALGQRLGQLALNRYPGTRQNDLKAALAAYA
GEPAGSAVLLGNGSDELISLVALACARAQATVLAPVPGFVMYAMSAQLQGLGFVGVPLTADFELDEAAMLDAIAQHRPAI
TFLAYPNNPTATLWDEAVVQRIIDAAGAQGGIVVMDEAYQPFASRSWIERMRAQPERNGHVLLMRTLSKFGLAGVRLGYM
IGPAALVAEVDKVRPPYNVSVLNTEAALFALEHADVFAAQADELRAARTELLAALRAMPGIERVWDSQANMVLVRVPDAA
RAYEGMKARKVLVKNVSTMHPLLAGCLRLTVGSSADNAQMLTALQASL
>Mature_367_residues
TTPSAELPALARIRDDVRAMQAYVVADATGYLKMDAMENPFGLPPALQAALGQRLGQLALNRYPGTRQNDLKAALAAYAG
EPAGSAVLLGNGSDELISLVALACARAQATVLAPVPGFVMYAMSAQLQGLGFVGVPLTADFELDEAAMLDAIAQHRPAIT
FLAYPNNPTATLWDEAVVQRIIDAAGAQGGIVVMDEAYQPFASRSWIERMRAQPERNGHVLLMRTLSKFGLAGVRLGYMI
GPAALVAEVDKVRPPYNVSVLNTEAALFALEHADVFAAQADELRAARTELLAALRAMPGIERVWDSQANMVLVRVPDAAR
AYEGMKARKVLVKNVSTMHPLLAGCLRLTVGSSADNAQMLTALQASL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=361, Percent_Identity=29.0858725761773, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322075, Length=385, Percent_Identity=26.4935064935065, Blast_Score=126, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_ACIET (B9MDV4)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552208.1
- ProteinModelPortal:   B9MDV4
- GeneID:   7383667
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0729
- ProtClustDB:   PRK04870
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39193; Mature: 39062

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPSAELPALARIRDDVRAMQAYVVADATGYLKMDAMENPFGLPPALQAALGQRLGQLA
CCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHH
LNRYPGTRQNDLKAALAAYAGEPAGSAVLLGNGSDELISLVALACARAQATVLAPVPGFV
HHCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEECCCHHH
MYAMSAQLQGLGFVGVPLTADFELDEAAMLDAIAQHRPAITFLAYPNNPTATLWDEAVVQ
HHHHHHHHCCCEEECCCEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
RIIDAAGAQGGIVVMDEAYQPFASRSWIERMRAQPERNGHVLLMRTLSKFGLAGVRLGYM
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCHHHHHHHHH
IGPAALVAEVDKVRPPYNVSVLNTEAALFALEHADVFAAQADELRAARTELLAALRAMPG
HHHHHHHHHHHHCCCCCCEEEEECHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IERVWDSQANMVLVRVPDAARAYEGMKARKVLVKNVSTMHPLLAGCLRLTVGSSADNAQM
HHHHHCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LTALQASL
HHHHHHCC
>Mature Secondary Structure 
TTPSAELPALARIRDDVRAMQAYVVADATGYLKMDAMENPFGLPPALQAALGQRLGQLA
CCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHH
LNRYPGTRQNDLKAALAAYAGEPAGSAVLLGNGSDELISLVALACARAQATVLAPVPGFV
HHCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEECCCHHH
MYAMSAQLQGLGFVGVPLTADFELDEAAMLDAIAQHRPAITFLAYPNNPTATLWDEAVVQ
HHHHHHHHCCCEEECCCEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
RIIDAAGAQGGIVVMDEAYQPFASRSWIERMRAQPERNGHVLLMRTLSKFGLAGVRLGYM
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCHHHHHHHHH
IGPAALVAEVDKVRPPYNVSVLNTEAALFALEHADVFAAQADELRAARTELLAALRAMPG
HHHHHHHHHHHHCCCCCCEEEEECHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IERVWDSQANMVLVRVPDAARAYEGMKARKVLVKNVSTMHPLLAGCLRLTVGSSADNAQM
HHHHHCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LTALQASL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA