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The map label for this gene is ahcY

Identifier: 222109813

GI number: 222109813

Start: 617084

End: 618514

Strand: Direct

Name: ahcY

Synonym: Dtpsy_0597

Alternate gene names: 222109813

Gene position: 617084-618514 (Clockwise)

Preceding gene: 222109809

Following gene: 222109814

Centisome position: 16.25

GC content: 65.13

Gene sequence:

>1431_bases
ATGAGCGCTGTTCTCAAGTCCCCAGCCGACTCAGCGATTGCCGATATCTCTCTGGCCGAGTGGGGCCGCAAGGAAATCCG
CATCGCCGAGACCGAGATGCCCGGCCTGATGGCCATCCGCGAGGAATTCGCCGCCAAGCAGCCCCTGAAGGGCGCGCGCA
TCACCGGCTCGCTGCACATGACCATCCAGACGGCCGTGCTGATCGAGACGCTCAAGGCCCTGGGCGCCGACGTGCGCTGG
GCCTCGTGCAACATCTTCTCCACCCAGGACCACGCCGCCGCCGCGATTGCCGCCACCGGCACGCCGGTGTTCGCCATCAA
GGGCGAGACCCTGGTGGACTACTGGGACTACACCCACCGCATCTTCGACTTCGGCCCCAAGGGCAGCGAGGGCGAAGGCC
CGAACATGATCCTGGACGACGGCGGCGACGCCACGCTGCTGATGCACCTGGGCAAGCGCGCCGAGAAGGACGCTTCCGTG
CTGGCCAACCCCGGCAGCGAGGAAGAGCGCATCCTGTTCGCCGCCATCAAGGCCAAGCTGGCCGAGGACAGCACCTGGTA
CAGCCGCAAGAGCGCCCAGATCATCGGCGTGACCGAAGAGACCACCACGGGCGTGCACCGCCTCAAGGAAATGTCGGCCA
AGGGCACGCTGATGTTCCGCGCCATCAACGTGAACGACTCGGTCACCAAGTCCAAGTTCGACAACCTGTACGGCTGCCGC
GAATCGCTGGTGGACGGCATCAAGCGCGCCACCGACGTGATGATTGCCGGCAAGGTGGCCGTGGTCTGCGGCTACGGCGA
CGTGGGCAAGGGCTCGGCCCAGGCACTGCGCGCCCTCAGCGCCCAGGTGTGGGTGACCGAGATCGACCCCATCAACGCCC
TGCAGGCCGCCATGGAAGGCTTCAAGGTCGTGACCATGGAGTGGGCGGCCGACAAGGCCGACATCTTCGTCACCACCACC
GGCAACCGCGACGTCATCACCTTCGAGCACATGAAGGCCATGAAGGACCAGGCCATCGTCTGCAACATCGGCCACTTCGA
CAACGAAATCCAGGTCGCCAAGCTCGAAGAGCATTGCCAGTGGGAAGAGATCAAGCCGCAGGTGGACCATGTGATCTTCC
CGGACGGCAAGCGCATCATCCTGCTGGCCAAGGGCCGCCTGGTGAACCTGGGCTGCGGCACGGGCCACCCCAGCTTTGTG
ATGTCCAACTCGTTCGCCAACCAGACCATCGCGCAGATCGAGCTGTTCACCCACCCCGAGGGCTACGACGTGGGCAAGGT
CTACGTGCTGCCCAAGCACCTCGACGAGAAGGTGGCGCGCCTGCACCTGAAGAAGGTCGGCGCCATGCTGACCGAGCTGA
GCGACGAGCAGGCCGCCTACATCGGCGTGCCGAAGCAGGGCCCCTACAAGCCCGACACCTACCGCTATTGA

Upstream 100 bases:

>100_bases
CGGAAGTCATACCCAGCAACGACGCTCACCCACGCCTTGCGGTGCGGTGAGTCCCATCCCCCAGGCGCGGTTTTTTCAGA
TACCCATCAAGGAAACCACC

Downstream 100 bases:

>100_bases
TTGTCAAAAAGCATAGCTGCTTGCGCTTGCCAGTAGCCGTTTTCAGTATGAAATATTGCTGAAAATGGCTCACTGCAAGC
GCTGCCAGCTATCGATATGA

Product: s-adenosyl-l-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSAVLKSPADSAIADISLAEWGRKEIRIAETEMPGLMAIREEFAAKQPLKGARITGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAATGTPVFAIKGETLVDYWDYTHRIFDFGPKGSEGEGPNMILDDGGDATLLMHLGKRAEKDASV
LANPGSEEERILFAAIKAKLAEDSTWYSRKSAQIIGVTEETTTGVHRLKEMSAKGTLMFRAINVNDSVTKSKFDNLYGCR
ESLVDGIKRATDVMIAGKVAVVCGYGDVGKGSAQALRALSAQVWVTEIDPINALQAAMEGFKVVTMEWAADKADIFVTTT
GNRDVITFEHMKAMKDQAIVCNIGHFDNEIQVAKLEEHCQWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSFV
MSNSFANQTIAQIELFTHPEGYDVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVPKQGPYKPDTYRY

Sequences:

>Translated_476_residues
MSAVLKSPADSAIADISLAEWGRKEIRIAETEMPGLMAIREEFAAKQPLKGARITGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAATGTPVFAIKGETLVDYWDYTHRIFDFGPKGSEGEGPNMILDDGGDATLLMHLGKRAEKDASV
LANPGSEEERILFAAIKAKLAEDSTWYSRKSAQIIGVTEETTTGVHRLKEMSAKGTLMFRAINVNDSVTKSKFDNLYGCR
ESLVDGIKRATDVMIAGKVAVVCGYGDVGKGSAQALRALSAQVWVTEIDPINALQAAMEGFKVVTMEWAADKADIFVTTT
GNRDVITFEHMKAMKDQAIVCNIGHFDNEIQVAKLEEHCQWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSFV
MSNSFANQTIAQIELFTHPEGYDVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVPKQGPYKPDTYRY
>Mature_475_residues
SAVLKSPADSAIADISLAEWGRKEIRIAETEMPGLMAIREEFAAKQPLKGARITGSLHMTIQTAVLIETLKALGADVRWA
SCNIFSTQDHAAAAIAATGTPVFAIKGETLVDYWDYTHRIFDFGPKGSEGEGPNMILDDGGDATLLMHLGKRAEKDASVL
ANPGSEEERILFAAIKAKLAEDSTWYSRKSAQIIGVTEETTTGVHRLKEMSAKGTLMFRAINVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKVAVVCGYGDVGKGSAQALRALSAQVWVTEIDPINALQAAMEGFKVVTMEWAADKADIFVTTTG
NRDVITFEHMKAMKDQAIVCNIGHFDNEIQVAKLEEHCQWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSFVM
SNSFANQTIAQIELFTHPEGYDVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVPKQGPYKPDTYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=466, Percent_Identity=59.656652360515, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI239937451, Length=446, Percent_Identity=59.4170403587444, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI298286489, Length=472, Percent_Identity=50, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI24308043, Length=472, Percent_Identity=50, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI195539337, Length=472, Percent_Identity=50, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI195539349, Length=472, Percent_Identity=50, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI21361647, Length=472, Percent_Identity=48.3050847457627, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17506425, Length=468, Percent_Identity=60.2564102564103, Blast_Score=530, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320882, Length=489, Percent_Identity=58.0777096114519, Blast_Score=499, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24642172, Length=465, Percent_Identity=60.6451612903226, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24656245, Length=457, Percent_Identity=50.9846827133479, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553387, Length=468, Percent_Identity=48.9316239316239, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI45553385, Length=467, Percent_Identity=48.8222698072805, Blast_Score=407, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_ACIET (B9MD45)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552077.1
- GeneID:   7382971
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0597
- ProtClustDB:   PRK05476
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52016; Mature: 51885

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 61-61 BINDING 140-140 BINDING 200-200 BINDING 230-230 BINDING 234-234 BINDING 235-235 BINDING 287-287 BINDING 322-322 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVLKSPADSAIADISLAEWGRKEIRIAETEMPGLMAIREEFAAKQPLKGARITGSLHM
CCCCCCCCCCHHHHCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAATGTPVFAIKGETLVDYWDYTHR
EHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCEEEEHHHHHHH
IFDFGPKGSEGEGPNMILDDGGDATLLMHLGKRAEKDASVLANPGSEEERILFAAIKAKL
HEECCCCCCCCCCCEEEEECCCCEEEEEHHCCCCCCCCCEEECCCCCHHEEEEEEHHHHH
AEDSTWYSRKSAQIIGVTEETTTGVHRLKEMSAKGTLMFRAINVNDSVTKSKFDNLYGCR
CCCCCHHCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
ESLVDGIKRATDVMIAGKVAVVCGYGDVGKGSAQALRALSAQVWVTEIDPINALQAAMEG
HHHHHHHHHHHHEEEECCEEEEECCCCCCCCHHHHHHHHHHEEEEEECCCHHHHHHHHCC
FKVVTMEWAADKADIFVTTTGNRDVITFEHMKAMKDQAIVCNIGHFDNEIQVAKLEEHCQ
CEEEEEEECCCCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCCEEEEEHHHCCC
WEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSFVMSNSFANQTIAQIELFTHPE
CHHCCCCCCEEECCCCCEEEEEECCCEEEEECCCCCCCEEEECCCCCCEEEEEEEEECCC
GYDVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVPKQGPYKPDTYRY
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SAVLKSPADSAIADISLAEWGRKEIRIAETEMPGLMAIREEFAAKQPLKGARITGSLHM
CCCCCCCCCHHHHCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAATGTPVFAIKGETLVDYWDYTHR
EHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCEEEEHHHHHHH
IFDFGPKGSEGEGPNMILDDGGDATLLMHLGKRAEKDASVLANPGSEEERILFAAIKAKL
HEECCCCCCCCCCCEEEEECCCCEEEEEHHCCCCCCCCCEEECCCCCHHEEEEEEHHHHH
AEDSTWYSRKSAQIIGVTEETTTGVHRLKEMSAKGTLMFRAINVNDSVTKSKFDNLYGCR
CCCCCHHCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
ESLVDGIKRATDVMIAGKVAVVCGYGDVGKGSAQALRALSAQVWVTEIDPINALQAAMEG
HHHHHHHHHHHHEEEECCEEEEECCCCCCCCHHHHHHHHHHEEEEEECCCHHHHHHHHCC
FKVVTMEWAADKADIFVTTTGNRDVITFEHMKAMKDQAIVCNIGHFDNEIQVAKLEEHCQ
CEEEEEEECCCCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCCEEEEEHHHCCC
WEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSFVMSNSFANQTIAQIELFTHPE
CHHCCCCCCEEECCCCCEEEEEECCCEEEEECCCCCCCEEEECCCCCCEEEEEEEEECCC
GYDVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVPKQGPYKPDTYRY
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA