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The map label for this gene is rmlA1 [H]

Identifier: 222109771

GI number: 222109771

Start: 573019

End: 573909

Strand: Direct

Name: rmlA1 [H]

Synonym: Dtpsy_0555

Alternate gene names: 222109771

Gene position: 573019-573909 (Clockwise)

Preceding gene: 222109770

Following gene: 222109772

Centisome position: 15.09

GC content: 64.76

Gene sequence:

>891_bases
ATGACGACACCCACGCGCAAGGGCATCATCCTGGCCGGCGGCTCCGGCACCCGCCTGCACCCGGCAACGCTTGCCATCAG
CAAGCAACTGCTGCCGGTGTATGACAAGCCCATGATCTACTACCCGCTGAGCACGCTGATGCTGGCGGGCATCCGCGAGA
TCCTCATCATCAGCACCCCGCAGGACACGCCCCGCTTTGAGCAACTGCTGGGGGACGGCAGCCAGTGGGGCCTGCAATTG
CAATACGCCGTGCAGCCGAGCCCCGACGGGCTGGCCCAGGCCTTCCTGATCGGTGAAGACTTCCTGGCCGGAAGCCCCAG
CGCGCTGGTGCTGGGCGACAACATCTTCTACGGCCACGACTTCCACGAACTGCTGGCCAATGCCATGGCCCGCCCGCAAG
GGGCCAGCGTCTTTGCCTACCACGTGCACGATCCCGAGCGCTATGGCGTGGCCGAATTCGATGCCAGCGGCAAAGTGCTG
AGCCTGGAGGAGAAACCCCAGAAGCCTAAGTCCAGCTACGCCGTCACGGGCCTGTACTTCTATGACAGCCAGGTGGTCGA
ACTGGCCAAGGGGCTCCAACCCAGCCCGCGCGGCGAACTGGAAATCACCGACCTCAACCGCCTGTACCTGGAGCAAGGCC
AATTGAGCGTCGAGATCATGGGCCGCGGCTACGCCTGGCTAGACACCGGCACGCACGACAGCCTGCTGGACGCCAGCCAA
TTCATCGCCACGCTGGAGCAGCGCCAGGGCTTGAAGATTGCCTGCCCCGAGGAAATCGCCTGGCGCAGCGGCTGGATCGA
TGCCGCCCGGCTGGAGCGACTGGCCCAGCCGCTGGCCAAGAACGGCTACGGCCAGTACCTGCAACGACTGCTGAAAGAGA
CGGTGTACTGA

Upstream 100 bases:

>100_bases
CCCGGCTGCAAACCACCTTCGGCCTGGTGCTGCCGCCTTGGCAGCAGGGCGTGGCGCGCATGCTCACCGAAATCCTCTGA
CCGAACACCCCCCCATTGCA

Downstream 100 bases:

>100_bases
TGAAAGCGACGCGACTGGCCATCCCCGAAGTGGTGCTGATCGAACCCCAAGTGTTCGGTGACGCACGGGGATTCTTCTTC
GAGAGCTTCAACCAGAAGAC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTTPTRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFEQLLGDGSQWGLQL
QYAVQPSPDGLAQAFLIGEDFLAGSPSALVLGDNIFYGHDFHELLANAMARPQGASVFAYHVHDPERYGVAEFDASGKVL
SLEEKPQKPKSSYAVTGLYFYDSQVVELAKGLQPSPRGELEITDLNRLYLEQGQLSVEIMGRGYAWLDTGTHDSLLDASQ
FIATLEQRQGLKIACPEEIAWRSGWIDAARLERLAQPLAKNGYGQYLQRLLKETVY

Sequences:

>Translated_296_residues
MTTPTRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFEQLLGDGSQWGLQL
QYAVQPSPDGLAQAFLIGEDFLAGSPSALVLGDNIFYGHDFHELLANAMARPQGASVFAYHVHDPERYGVAEFDASGKVL
SLEEKPQKPKSSYAVTGLYFYDSQVVELAKGLQPSPRGELEITDLNRLYLEQGQLSVEIMGRGYAWLDTGTHDSLLDASQ
FIATLEQRQGLKIACPEEIAWRSGWIDAARLERLAQPLAKNGYGQYLQRLLKETVY
>Mature_295_residues
TTPTRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFEQLLGDGSQWGLQLQ
YAVQPSPDGLAQAFLIGEDFLAGSPSALVLGDNIFYGHDFHELLANAMARPQGASVFAYHVHDPERYGVAEFDASGKVLS
LEEKPQKPKSSYAVTGLYFYDSQVVELAKGLQPSPRGELEITDLNRLYLEQGQLSVEIMGRGYAWLDTGTHDSLLDASQF
IATLEQRQGLKIACPEEIAWRSGWIDAARLERLAQPLAKNGYGQYLQRLLKETVY

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=247, Percent_Identity=25.5060728744939, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI11761621, Length=247, Percent_Identity=25.5060728744939, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=73.7024221453287, Blast_Score=463, Evalue=1e-132,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=68.5314685314685, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1787488, Length=300, Percent_Identity=26.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=182, Percent_Identity=25.2747252747253, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=274, Percent_Identity=26.6423357664234, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=25.4980079681275, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=25.4980079681275, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32701; Mature: 32569

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTP
CCCCCCCCEEEECCCCCEECHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECC
QDTPRFEQLLGDGSQWGLQLQYAVQPSPDGLAQAFLIGEDFLAGSPSALVLGDNIFYGHD
CCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHEEEECCHHHCCCCCEEEEECCEEECCC
FHELLANAMARPQGASVFAYHVHDPERYGVAEFDASGKVLSLEEKPQKPKSSYAVTGLYF
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEE
YDSQVVELAKGLQPSPRGELEITDLNRLYLEQGQLSVEIMGRGYAWLDTGTHDSLLDASQ
ECHHHHHHHHCCCCCCCCCEEEECCHHHHHHCCCEEEEEEECCEEEEECCCCHHHHHHHH
FIATLEQRQGLKIACPEEIAWRSGWIDAARLERLAQPLAKNGYGQYLQRLLKETVY
HHHHHHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTPTRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTP
CCCCCCCEEEECCCCCEECHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECC
QDTPRFEQLLGDGSQWGLQLQYAVQPSPDGLAQAFLIGEDFLAGSPSALVLGDNIFYGHD
CCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHEEEECCHHHCCCCCEEEEECCEEECCC
FHELLANAMARPQGASVFAYHVHDPERYGVAEFDASGKVLSLEEKPQKPKSSYAVTGLYF
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEE
YDSQVVELAKGLQPSPRGELEITDLNRLYLEQGQLSVEIMGRGYAWLDTGTHDSLLDASQ
ECHHHHHHHHCCCCCCCCCEEEECCHHHHHHCCCEEEEEEECCEEEEECCCCHHHHHHHH
FIATLEQRQGLKIACPEEIAWRSGWIDAARLERLAQPLAKNGYGQYLQRLLKETVY
HHHHHHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]