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The map label for this gene is trxC [C]

Identifier: 222109736

GI number: 222109736

Start: 537416

End: 537853

Strand: Direct

Name: trxC [C]

Synonym: Dtpsy_0520

Alternate gene names: 222109736

Gene position: 537416-537853 (Clockwise)

Preceding gene: 222109732

Following gene: 222109741

Centisome position: 14.16

GC content: 70.55

Gene sequence:

>438_bases
ATGAGCTCCCCCGAAGCACTGCACGTCGTCTGCCCCCACTGCCACACCACCAACCGCGTGCAGGCCGCGCAACTGGGCAG
TGCGCCCGACTGCGGCAGCTGCCATCGGCCACTGTTCACGGGCGAACCGCTGGCGCTGGATGCGGCCAGCTTCGACCGGC
ACGTAGCGCGCAGCCATCTGCCCGTGGTGGTGGACTTCTGGGCGCCGTGGTGTGGCCCCTGCCGCCAGATGGCGCCAGCC
TTCGCTCAGGCTGCGCGCGAGTTGGAGCCGCGCGTGCGGCTGGCCAAGCTGGATACCGAGGCGCACCCCGCGATCGCGGC
GCGCTACGGCATCCGCAGCATCCCGACGATGATCCTGTTTCGCGGCGGACAGGAGGCAGCGCGCATCTCTGGTGCGCTGG
GTGCGGCCGATATCGCGCGCTGGGTGCAGTCGGTGTAA

Upstream 100 bases:

>100_bases
CGCGGCCACTGTAGGCCGGCTACCCGCAGGGCCGTAGGCATTGAAAACGTGACCCCTTACCCGCAATTGCCTGGTTTCGC
CAACCCCCGCGAGGTCCTCC

Downstream 100 bases:

>100_bases
GGCGCTGCGGAACCAACCCTCGTGTGGCGCTCGCCCCTGTTGTGGGGCCGCAGCGCTGACGATTCGCCATACCAGTGGCT
GTTGCTGCGTACCCGCAGCC

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MSSPEALHVVCPHCHTTNRVQAAQLGSAPDCGSCHRPLFTGEPLALDAASFDRHVARSHLPVVVDFWAPWCGPCRQMAPA
FAQAARELEPRVRLAKLDTEAHPAIAARYGIRSIPTMILFRGGQEAARISGALGAADIARWVQSV

Sequences:

>Translated_145_residues
MSSPEALHVVCPHCHTTNRVQAAQLGSAPDCGSCHRPLFTGEPLALDAASFDRHVARSHLPVVVDFWAPWCGPCRQMAPA
FAQAARELEPRVRLAKLDTEAHPAIAARYGIRSIPTMILFRGGQEAARISGALGAADIARWVQSV
>Mature_144_residues
SSPEALHVVCPHCHTTNRVQAAQLGSAPDCGSCHRPLFTGEPLALDAASFDRHVARSHLPVVVDFWAPWCGPCRQMAPAF
AQAARELEPRVRLAKLDTEAHPAIAARYGIRSIPTMILFRGGQEAARISGALGAADIARWVQSV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI20070125, Length=105, Percent_Identity=37.1428571428571, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI224493972, Length=140, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI42794771, Length=140, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI5031973, Length=93, Percent_Identity=37.6344086021505, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI95113651, Length=82, Percent_Identity=40.2439024390244, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI4758304, Length=95, Percent_Identity=36.8421052631579, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI21361657, Length=77, Percent_Identity=40.2597402597403, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI21361403, Length=85, Percent_Identity=32.9411764705882, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI94966757, Length=92, Percent_Identity=35.8695652173913, Blast_Score=63, Evalue=1e-10,
Organism=Escherichia coli, GI1788936, Length=138, Percent_Identity=40.5797101449275, Blast_Score=130, Evalue=2e-32,
Organism=Escherichia coli, GI87082331, Length=95, Percent_Identity=40, Blast_Score=94, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17556044, Length=105, Percent_Identity=35.2380952380952, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=32.2916666666667, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193209454, Length=84, Percent_Identity=34.5238095238095, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17549970, Length=106, Percent_Identity=34.9056603773585, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=66, Percent_Identity=39.3939393939394, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=66, Percent_Identity=39.3939393939394, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=86, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=85, Percent_Identity=42.3529411764706, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=41.6666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=103, Percent_Identity=31.0679611650485, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507915, Length=106, Percent_Identity=31.1320754716981, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=95, Percent_Identity=35.7894736842105, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=101, Percent_Identity=33.6633663366337, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=38.2022471910112, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=36.4705882352941, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=78, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19921434, Length=102, Percent_Identity=39.2156862745098, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647799, Length=84, Percent_Identity=42.8571428571429, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573567, Length=109, Percent_Identity=33.0275229357798, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358065, Length=135, Percent_Identity=27.4074074074074, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551086, Length=92, Percent_Identity=32.6086956521739, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 15615; Mature: 15484

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPEALHVVCPHCHTTNRVQAAQLGSAPDCGSCHRPLFTGEPLALDAASFDRHVARSHL
CCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHCCC
PVVVDFWAPWCGPCRQMAPAFAQAARELEPRVRLAKLDTEAHPAIAARYGIRSIPTMILF
CEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHCHHHHCHHEEE
RGGQEAARISGALGAADIARWVQSV
CCCCHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SSPEALHVVCPHCHTTNRVQAAQLGSAPDCGSCHRPLFTGEPLALDAASFDRHVARSHL
CCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHCCC
PVVVDFWAPWCGPCRQMAPAFAQAARELEPRVRLAKLDTEAHPAIAARYGIRSIPTMILF
CEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHCHHHHCHHEEE
RGGQEAARISGALGAADIARWVQSV
CCCCHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8652661 [H]