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The map label for this gene is ubiA

Identifier: 222109591

GI number: 222109591

Start: 383597

End: 384469

Strand: Direct

Name: ubiA

Synonym: Dtpsy_0371

Alternate gene names: 222109591

Gene position: 383597-384469 (Clockwise)

Preceding gene: 222109590

Following gene: 222109595

Centisome position: 10.1

GC content: 68.84

Gene sequence:

>873_bases
ATGTCCGCTGTCGCCCCGCGCTCCCGCCTGTCCCTGTACCTCGACCTGATCCGCTGGAACCGCCCCGCGGGCTGGCTGGT
GCTGGTGTGGCCCACGCTGGCGGCGCTGTGGGTGGCGGCGGACGGCTTTCCAGGCTGGCACCTGCTGGCGGTGTTCGTGG
CCGGCACGGTGCTCATGCGCAGCGCCGGTTGCACCATCAACGACATTGCCGACCGCGACTTCGACCGCCATGTGAAGCGC
ACCACGCAGCGCCCCATCACCAGCGGCCAGCTGGGCGTGAGGGAGGCCGCGCTGGTGGGCGTGGTGCTCACGCTGGTGGC
TTTCGTGCTGGTGCTCACCACGCGCTGGGAGGCGGTGGCCTGGTCGGTGCCCGCGGTGCTGTTCACCATCCTGTACCCGT
TCACCAAGCGGTTCTTCGCCATGCCGCAGGCGTTCCTGGGCATTGCGTTCAACTTCGGCATCGTGATCGCCTTTGCGGCC
GTGCAGGGCCGGGTGCCTGCCACGGCCTGGGTGCTGTGGCTGGCCAACCTGTTCCTGGTGCTGGCCTACGACACCGAGTA
CGCCATGGTGGACCGCGACGACGATCTGAAGATCGGCATGAAGACCTCGGCCATCACGCTGGGGCGCTTCGACGTGGCGG
CCATCATGGGCTTCTTCGTGCTGTGCCTGGGGCTCACGGCGTGGGTGCTCGCGCCCTACGGCCTGGGCTGGCCGCTGTGG
CTGGGGCTGGGCGTGGCGGCGGCGCAGGTGGCATGGCACTTCACGCTGATCAAGGACCGCACGCGCGAGGGGTGCTTTAC
CGCCTTCAGCAAGAGCCACTGGATCGGCGCGGCGATCTTTGCCGGCGTGGCGCTAGGGTATTTGCTGCGCTAG

Upstream 100 bases:

>100_bases
CCCGTGTGCTGCGTCGTCCGCGGGCCTTGTGTCCTTTGTGCCCTCGGTGTCCGTGTCCGCCCCGTGGCGCCCCGCGCAAC
CTGTCTTTTCCCTTGCCTCC

Downstream 100 bases:

>100_bases
TGATAGCTGCCAGCGCTTGACTGTCAAGCGCTGGCAGCTATTTTTGACGCATGAATCAGGCGCCGAACTCGGCCGCCAGT
TCCTTGGCACGGGCCTCTGC

Product: 4-hydroxybenzoate polyprenyl transferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSAVAPRSRLSLYLDLIRWNRPAGWLVLVWPTLAALWVAADGFPGWHLLAVFVAGTVLMRSAGCTINDIADRDFDRHVKR
TTQRPITSGQLGVREAALVGVVLTLVAFVLVLTTRWEAVAWSVPAVLFTILYPFTKRFFAMPQAFLGIAFNFGIVIAFAA
VQGRVPATAWVLWLANLFLVLAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAAIMGFFVLCLGLTAWVLAPYGLGWPLW
LGLGVAAAQVAWHFTLIKDRTREGCFTAFSKSHWIGAAIFAGVALGYLLR

Sequences:

>Translated_290_residues
MSAVAPRSRLSLYLDLIRWNRPAGWLVLVWPTLAALWVAADGFPGWHLLAVFVAGTVLMRSAGCTINDIADRDFDRHVKR
TTQRPITSGQLGVREAALVGVVLTLVAFVLVLTTRWEAVAWSVPAVLFTILYPFTKRFFAMPQAFLGIAFNFGIVIAFAA
VQGRVPATAWVLWLANLFLVLAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAAIMGFFVLCLGLTAWVLAPYGLGWPLW
LGLGVAAAQVAWHFTLIKDRTREGCFTAFSKSHWIGAAIFAGVALGYLLR
>Mature_289_residues
SAVAPRSRLSLYLDLIRWNRPAGWLVLVWPTLAALWVAADGFPGWHLLAVFVAGTVLMRSAGCTINDIADRDFDRHVKRT
TQRPITSGQLGVREAALVGVVLTLVAFVLVLTTRWEAVAWSVPAVLFTILYPFTKRFFAMPQAFLGIAFNFGIVIAFAAV
QGRVPATAWVLWLANLFLVLAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAAIMGFFVLCLGLTAWVLAPYGLGWPLWL
GLGVAAAQVAWHFTLIKDRTREGCFTAFSKSHWIGAAIFAGVALGYLLR

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=288, Percent_Identity=34.375, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1790473, Length=281, Percent_Identity=45.9074733096085, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17553718, Length=287, Percent_Identity=33.7979094076655, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32565247, Length=286, Percent_Identity=32.1678321678322, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17553720, Length=344, Percent_Identity=29.0697674418605, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=37.5886524822695, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI32565243, Length=137, Percent_Identity=37.2262773722628, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324370, Length=292, Percent_Identity=31.8493150684932, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21355567, Length=289, Percent_Identity=33.9100346020761, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_ACIET (B9MBT5)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002551855.1
- GeneID:   7385379
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0371
- ProtClustDB:   CLSK951796
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 31925; Mature: 31794

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x210666dc)-; HASH(0x20f56160)-; HASH(0x20c91cd8)-; HASH(0x21223bd8)-; HASH(0x21a2d6c0)-; HASH(0x21eb31c8)-; HASH(0x222aa63c)-; HASH(0x225922e4)-; HASH(0x2259b190)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVAPRSRLSLYLDLIRWNRPAGWLVLVWPTLAALWVAADGFPGWHLLAVFVAGTVLMR
CCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SAGCTINDIADRDFDRHVKRTTQRPITSGQLGVREAALVGVVLTLVAFVLVLTTRWEAVA
HCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHH
WSVPAVLFTILYPFTKRFFAMPQAFLGIAFNFGIVIAFAAVQGRVPATAWVLWLANLFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAAIMGFFVLCLGLTAWVLAPYGLGWPLW
HEECCCEEEECCCCCCEEECEECEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LGLGVAAAQVAWHFTLIKDRTREGCFTAFSKSHWIGAAIFAGVALGYLLR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SAVAPRSRLSLYLDLIRWNRPAGWLVLVWPTLAALWVAADGFPGWHLLAVFVAGTVLMR
CCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SAGCTINDIADRDFDRHVKRTTQRPITSGQLGVREAALVGVVLTLVAFVLVLTTRWEAVA
HCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHH
WSVPAVLFTILYPFTKRFFAMPQAFLGIAFNFGIVIAFAAVQGRVPATAWVLWLANLFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAAIMGFFVLCLGLTAWVLAPYGLGWPLW
HEECCCEEEECCCCCCEEECEECEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LGLGVAAAQVAWHFTLIKDRTREGCFTAFSKSHWIGAAIFAGVALGYLLR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA