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The map label for this gene is ung [H]

Identifier: 222109583

GI number: 222109583

Start: 373907

End: 374620

Strand: Direct

Name: ung [H]

Synonym: Dtpsy_0363

Alternate gene names: 222109583

Gene position: 373907-374620 (Clockwise)

Preceding gene: 222109582

Following gene: 222109587

Centisome position: 9.85

GC content: 71.29

Gene sequence:

>714_bases
ATGCTAAATACTCCCGCCGCCACGCAACTGCAAAGCGCCGACCCCGCCGACTGGCCTGTCGCGCCGGGCTGGCAGCCGCT
GGTCGACACGTTCTTTGCCAGCGCGCGCGGCCGGCAGTTGCTGGCCTTCCTGCAGGCGCGGCTGGAGGCCGGCGCCGCCA
TCTTCCCGCCGCAGCCGCTGCGGGCGCTGCAGCTCACGGCCCCCGAGGACACGCGCGTGGTCATCCTGGGGCAGGACCCG
TACCACGGCCGTGGCCAGGCCGAGGGGCTCGCGTTCTCGGTGGCGCCGGGCGTGCGCCTGCCGCCCTCGCTGCAGAACAT
CTTCAAGGAAATGCAGCGCGACATGGGCGTACCCTTCCCACCGTTTCCCAACCCGGGCGGCAGCCTGGTGAAGTGGGCAC
AGAACGGTGTGCTGCTGCTCAACACCTGCCTCACGGTGGAAGAGGGCCAGGCCGCGAGCCACGCGGGCAAGGGCTGGGAG
CAGCTGACCGATGCCGTCATCCGCGAGGTGGCCGAAGGGCCGCGCCCCGTGGTGTTCATGCTCTGGGGCAGCCATGCGCA
GTCCAAGCGCGCCTTCATCCCGCGGGACCGGGGGCACCTGGTGCTTACCTCCAACCATCCCTCGCCGTTGTCGGCGCTGC
GCCCGCCCGTGCCGTTCATCGGCAACGGCCACTTCGGCCAGGCGCGGGCGTTCCGCCAGCAGCACGGGTACTGA

Upstream 100 bases:

>100_bases
CGCCAAGGCGGCAGGCCGCAACCGGGTGCATGATGGAATGGATTAGCTATCGTAAATATAGCTTGTAGCGCAGAATGGAT
AAGCCTTGGAGCATGATTTG

Downstream 100 bases:

>100_bases
TCAGCGCCGCTCGCGCACCGTCAGCCAGGCGCTCGCAGCGCCACTGGCGGCGATCAGGCAGATGCCCAGCAGCGACCAGC
GGTCCGGCATGTGGCCGTAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MLNTPAATQLQSADPADWPVAPGWQPLVDTFFASARGRQLLAFLQARLEAGAAIFPPQPLRALQLTAPEDTRVVILGQDP
YHGRGQAEGLAFSVAPGVRLPPSLQNIFKEMQRDMGVPFPPFPNPGGSLVKWAQNGVLLLNTCLTVEEGQAASHAGKGWE
QLTDAVIREVAEGPRPVVFMLWGSHAQSKRAFIPRDRGHLVLTSNHPSPLSALRPPVPFIGNGHFGQARAFRQQHGY

Sequences:

>Translated_237_residues
MLNTPAATQLQSADPADWPVAPGWQPLVDTFFASARGRQLLAFLQARLEAGAAIFPPQPLRALQLTAPEDTRVVILGQDP
YHGRGQAEGLAFSVAPGVRLPPSLQNIFKEMQRDMGVPFPPFPNPGGSLVKWAQNGVLLLNTCLTVEEGQAASHAGKGWE
QLTDAVIREVAEGPRPVVFMLWGSHAQSKRAFIPRDRGHLVLTSNHPSPLSALRPPVPFIGNGHFGQARAFRQQHGY
>Mature_237_residues
MLNTPAATQLQSADPADWPVAPGWQPLVDTFFASARGRQLLAFLQARLEAGAAIFPPQPLRALQLTAPEDTRVVILGQDP
YHGRGQAEGLAFSVAPGVRLPPSLQNIFKEMQRDMGVPFPPFPNPGGSLVKWAQNGVLLLNTCLTVEEGQAASHAGKGWE
QLTDAVIREVAEGPRPVVFMLWGSHAQSKRAFIPRDRGHLVLTSNHPSPLSALRPPVPFIGNGHFGQARAFRQQHGY

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=43.5185185185185, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=43.5185185185185, Blast_Score=153, Evalue=1e-37,
Organism=Escherichia coli, GI1788934, Length=199, Percent_Identity=50.251256281407, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17556304, Length=196, Percent_Identity=40.3061224489796, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6323620, Length=224, Percent_Identity=38.3928571428571, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25709; Mature: 25709

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTPAATQLQSADPADWPVAPGWQPLVDTFFASARGRQLLAFLQARLEAGAAIFPPQPL
CCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCC
RALQLTAPEDTRVVILGQDPYHGRGQAEGLAFSVAPGVRLPPSLQNIFKEMQRDMGVPFP
CEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
PFPNPGGSLVKWAQNGVLLLNTCLTVEEGQAASHAGKGWEQLTDAVIREVAEGPRPVVFM
CCCCCCCHHHHHHCCCEEEEEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEE
LWGSHAQSKRAFIPRDRGHLVLTSNHPSPLSALRPPVPFIGNGHFGQARAFRQQHGY
EECCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLNTPAATQLQSADPADWPVAPGWQPLVDTFFASARGRQLLAFLQARLEAGAAIFPPQPL
CCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCC
RALQLTAPEDTRVVILGQDPYHGRGQAEGLAFSVAPGVRLPPSLQNIFKEMQRDMGVPFP
CEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
PFPNPGGSLVKWAQNGVLLLNTCLTVEEGQAASHAGKGWEQLTDAVIREVAEGPRPVVFM
CCCCCCCHHHHHHCCCEEEEEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEE
LWGSHAQSKRAFIPRDRGHLVLTSNHPSPLSALRPPVPFIGNGHFGQARAFRQQHGY
EECCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA