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The map label for this gene is arpR [H]

Identifier: 222109539

GI number: 222109539

Start: 330960

End: 331580

Strand: Direct

Name: arpR [H]

Synonym: Dtpsy_0319

Alternate gene names: 222109539

Gene position: 330960-331580 (Clockwise)

Preceding gene: 222109534

Following gene: 222109540

Centisome position: 8.72

GC content: 61.84

Gene sequence:

>621_bases
ATGGCACGACGTACCAAGGAAGATGCAGATGCTACGCGCAACAGCCTTTTGGATGCTGCCGAGCGTGTGTTCTACGAAAA
AGGCGTGTCGCGCGCCTCGCTGAGCGACATTGCCCAGGCTGCGGGCGCCACGCGCGGCGCGATCTACTGGCATTTCAAGG
ACAAAGTGGCCTTGTTCAATGCCATGATGGACCGGGTGACCCACCCGCTGGAGCAGGTGGGCAGCAAGAGCGCCAGCATG
GCCACTCTGCCCCCGTTGGAGCGGCTGCGCTCCATGGTGGACTTCGTCCAGCGCACCATCGTCCAGGACGAGCGCACGCG
CCGGGTGTTCGAGATCGCGTTGTACCGGGTCGAATACGTCAACGACCTCGCGGCGGTGCGCGACAACCATATCGAAGGCT
GTGCAGATTTTTGCGCGCTGATCGAGGGTGAATTGCGTTCGGCGGCAGAAGACCAGAACCTGCAATTGCCGATGGAGCCA
CACACCGCCGCGATGGGTGTACAGGCGCTGTTCGATGGCCTGCTGCAGTCCTGGTTGCTGACCCATGGACGCTTCGATCT
GGTGACCGTCAGCCGAGGCGCCATTGACGCTTATCTGCGGGGGTTGGGTTTTCGTCTGTAG

Upstream 100 bases:

>100_bases
ACAGACGCGCAAAGGGGAATGATTATACATACATCCATGAATGTATAATTACTTGGAAAGCGCGGCCGTTGCTGTATCCA
CGTTTTGGAGGTTCCCATCC

Downstream 100 bases:

>100_bases
CCACAGCCACGTGCGATAATCCGCCGCTTGTTCGCCATCGGGCGGACTTTCCCAGCGGCTGTAGCTCAGTGGATAGAGTA
TTGGCCTCCGAAGCCAAGGG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MARRTKEDADATRNSLLDAAERVFYEKGVSRASLSDIAQAAGATRGAIYWHFKDKVALFNAMMDRVTHPLEQVGSKSASM
ATLPPLERLRSMVDFVQRTIVQDERTRRVFEIALYRVEYVNDLAAVRDNHIEGCADFCALIEGELRSAAEDQNLQLPMEP
HTAAMGVQALFDGLLQSWLLTHGRFDLVTVSRGAIDAYLRGLGFRL

Sequences:

>Translated_206_residues
MARRTKEDADATRNSLLDAAERVFYEKGVSRASLSDIAQAAGATRGAIYWHFKDKVALFNAMMDRVTHPLEQVGSKSASM
ATLPPLERLRSMVDFVQRTIVQDERTRRVFEIALYRVEYVNDLAAVRDNHIEGCADFCALIEGELRSAAEDQNLQLPMEP
HTAAMGVQALFDGLLQSWLLTHGRFDLVTVSRGAIDAYLRGLGFRL
>Mature_205_residues
ARRTKEDADATRNSLLDAAERVFYEKGVSRASLSDIAQAAGATRGAIYWHFKDKVALFNAMMDRVTHPLEQVGSKSASMA
TLPPLERLRSMVDFVQRTIVQDERTRRVFEIALYRVEYVNDLAAVRDNHIEGCADFCALIEGELRSAAEDQNLQLPMEPH
TAAMGVQALFDGLLQSWLLTHGRFDLVTVSRGAIDAYLRGLGFRL

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=195, Percent_Identity=34.8717948717949, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1789664, Length=205, Percent_Identity=29.7560975609756, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23047; Mature: 22915

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRTKEDADATRNSLLDAAERVFYEKGVSRASLSDIAQAAGATRGAIYWHFKDKVALFN
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHH
AMMDRVTHPLEQVGSKSASMATLPPLERLRSMVDFVQRTIVQDERTRRVFEIALYRVEYV
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDLAAVRDNHIEGCADFCALIEGELRSAAEDQNLQLPMEPHTAAMGVQALFDGLLQSWLL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
THGRFDLVTVSRGAIDAYLRGLGFRL
HCCCCEEEEECHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARRTKEDADATRNSLLDAAERVFYEKGVSRASLSDIAQAAGATRGAIYWHFKDKVALFN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHH
AMMDRVTHPLEQVGSKSASMATLPPLERLRSMVDFVQRTIVQDERTRRVFEIALYRVEYV
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDLAAVRDNHIEGCADFCALIEGELRSAAEDQNLQLPMEPHTAAMGVQALFDGLLQSWLL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
THGRFDLVTVSRGAIDAYLRGLGFRL
HCCCCEEEEECHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]