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The map label for this gene is lysR [H]

Identifier: 222102719

GI number: 222102719

Start: 369971

End: 370864

Strand: Direct

Name: lysR [H]

Synonym: Avi_7396

Alternate gene names: 222102719

Gene position: 369971-370864 (Clockwise)

Preceding gene: 222102718

Following gene: 222102722

Centisome position: 58.56

GC content: 56.38

Gene sequence:

>894_bases
ATGTTGCATGGCACGACGACGAAGGCGGCCGATGCCCTCGACATCACCCAGCCAGCAGTTAGCAAAATCCTGTTGCAGCT
GACGAACAAGGCTGGCTTTCCGCTATTTCGCAACCATCGTCAGCGTTTGATCCCGACACCGGAAGCCCACATGCTCTATG
CTGAGGTGCGCCGGTTGTTCGAGACGGTTCGCGGAATATCGCAAATCGCGAAGGAAATCCGGGAGCTCCGGAGTGGCCGT
CTCAACATCTCAGCCCTGCCTGCTTTCGGGTCGACGCTGATGCCTTCGATCATTGCAAGCTTCACGAAACAATATCCCGA
CGTCGCCATAACCCTGGATATCAGGAGCTCGTCGACAATCATCCAGCGGGCGGGGCGAAATCAGCTCGATATCGGTGTCG
CGTCAGAGGTCAACGATGAGACACCGTCGGTGGTTCGGCGTGCACTCATTGCCACCCCTCCGGTCTGCGTCATGCCCAAG
GGCCATCCGCTGAGCAAACTTTCCGTCGTCCAACCAGACGATTTTGACGGCTTGAATTTCGTGTCGTTGGGCGTCGGTGA
TCCGATGCGCAAACAGCTTGACGAACTCTGTGAGCAAAGAGGGGTGAACCGCTCCCTCAAGGTTGAGGCGGCACTTTCGC
ATTCCTGTATTAATCTGGTTGCCAACGGGGTTGGGGTGACGGTGGTGGATCGCCTTTCCGCTTGGATGGCAAAAGACCTG
CCAATTGAGATCCGCGACTTCCAGCCGCATCTCGACATCAATCTTAGCGTCTATAGACCATGGGGCACAATCGCCTCGTC
TGTGGCCGACACCTTCATCGAGCATCTTATCCAGTCGACGCGGGAATATATGAACGTCGTTGACCGTGGGATCAAAGCCC
TCAGCGAGCAGTAA

Upstream 100 bases:

>100_bases
CTAATCGAGGCCTCTTTGCTGTTTCTCGTCAATGGAGGCTAGGGTGATCCCAGGGGATGTGGATTTTACACCGCGTGAGG
TCGAGGTCTTTGCGGCGGTC

Downstream 100 bases:

>100_bases
TACGAAGATTCATTGAAAATGACTCTTCGTATTCCTTTTGAAAATATCTCAAGCCTCTGACGCATTGGAGATATTTTCAA
TGTCTTCAAGTCGAGGATGC

Product: Transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLHGTTTKAADALDITQPAVSKILLQLTNKAGFPLFRNHRQRLIPTPEAHMLYAEVRRLFETVRGISQIAKEIRELRSGR
LNISALPAFGSTLMPSIIASFTKQYPDVAITLDIRSSSTIIQRAGRNQLDIGVASEVNDETPSVVRRALIATPPVCVMPK
GHPLSKLSVVQPDDFDGLNFVSLGVGDPMRKQLDELCEQRGVNRSLKVEAALSHSCINLVANGVGVTVVDRLSAWMAKDL
PIEIRDFQPHLDINLSVYRPWGTIASSVADTFIEHLIQSTREYMNVVDRGIKALSEQ

Sequences:

>Translated_297_residues
MLHGTTTKAADALDITQPAVSKILLQLTNKAGFPLFRNHRQRLIPTPEAHMLYAEVRRLFETVRGISQIAKEIRELRSGR
LNISALPAFGSTLMPSIIASFTKQYPDVAITLDIRSSSTIIQRAGRNQLDIGVASEVNDETPSVVRRALIATPPVCVMPK
GHPLSKLSVVQPDDFDGLNFVSLGVGDPMRKQLDELCEQRGVNRSLKVEAALSHSCINLVANGVGVTVVDRLSAWMAKDL
PIEIRDFQPHLDINLSVYRPWGTIASSVADTFIEHLIQSTREYMNVVDRGIKALSEQ
>Mature_297_residues
MLHGTTTKAADALDITQPAVSKILLQLTNKAGFPLFRNHRQRLIPTPEAHMLYAEVRRLFETVRGISQIAKEIRELRSGR
LNISALPAFGSTLMPSIIASFTKQYPDVAITLDIRSSSTIIQRAGRNQLDIGVASEVNDETPSVVRRALIATPPVCVMPK
GHPLSKLSVVQPDDFDGLNFVSLGVGDPMRKQLDELCEQRGVNRSLKVEAALSHSCINLVANGVGVTVVDRLSAWMAKDL
PIEIRDFQPHLDINLSVYRPWGTIASSVADTFIEHLIQSTREYMNVVDRGIKALSEQ

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=277, Percent_Identity=32.8519855595668, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI157672245, Length=210, Percent_Identity=30.952380952381, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790399, Length=231, Percent_Identity=22.9437229437229, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788481, Length=129, Percent_Identity=30.2325581395349, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788887, Length=228, Percent_Identity=24.5614035087719, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32754; Mature: 32754

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHGTTTKAADALDITQPAVSKILLQLTNKAGFPLFRNHRQRLIPTPEAHMLYAEVRRLF
CCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHCCHHCCCCCHHHHHHHHHHHHH
ETVRGISQIAKEIRELRSGRLNISALPAFGSTLMPSIIASFTKQYPDVAITLDIRSSSTI
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHH
IQRAGRNQLDIGVASEVNDETPSVVRRALIATPPVCVMPKGHPLSKLSVVQPDDFDGLNF
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCEEEECCCCCCCCCE
VSLGVGDPMRKQLDELCEQRGVNRSLKVEAALSHSCINLVANGVGVTVVDRLSAWMAKDL
EEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
PIEIRDFQPHLDINLSVYRPWGTIASSVADTFIEHLIQSTREYMNVVDRGIKALSEQ
CEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLHGTTTKAADALDITQPAVSKILLQLTNKAGFPLFRNHRQRLIPTPEAHMLYAEVRRLF
CCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHCCHHCCCCCHHHHHHHHHHHHH
ETVRGISQIAKEIRELRSGRLNISALPAFGSTLMPSIIASFTKQYPDVAITLDIRSSSTI
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHH
IQRAGRNQLDIGVASEVNDETPSVVRRALIATPPVCVMPKGHPLSKLSVVQPDDFDGLNF
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCEEEECCCCCCCCCE
VSLGVGDPMRKQLDELCEQRGVNRSLKVEAALSHSCINLVANGVGVTVVDRLSAWMAKDL
EEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
PIEIRDFQPHLDINLSVYRPWGTIASSVADTFIEHLIQSTREYMNVVDRGIKALSEQ
CEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]