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The map label for this gene is qor [C]

Identifier: 222102698

GI number: 222102698

Start: 346190

End: 347104

Strand: Direct

Name: qor [C]

Synonym: Avi_7371

Alternate gene names: 222102698

Gene position: 346190-347104 (Clockwise)

Preceding gene: 222102696

Following gene: 222102699

Centisome position: 54.8

GC content: 56.83

Gene sequence:

>915_bases
ATGAAAGCAATCATTATCAACGAATATGGCGACAACAGCGTGCTTAAATATGCCGACGTCAAAGATCCTGAGCCGAAAGC
AGGCGAAGTGCTGGTTAAAGTCCATGCGGCAGGCGTCAACCCTGTGGATTGGAAGATTCGCAGTGGCGCTGGCCAGCGAA
TGGGGATGACCTTGCCAATCCATCTGGGCGGAGAGATTGCAGGCATTGTCGAAAAACTTGGACCAGGCGTCACCGAATTC
AATCGAGGCGACGGCGTCTACGGCGTTATCAAACAGGGAGGTTTCGCGCAGTATGCGATCGCCAACACGACGGATGTCGC
GCGCAAGCCCTCCACCCTCGATTTCATCGAAACGGCTGCTACGCCGCTCGGAGCATTAACCGCGTGGCAGGCCATGTTTG
ACGTTGCCAAACTTTCGACCGGCCAGCACGTGTTCATCACAAACAGCTCGGGCGGCGTCGGCTCCCTGGCAGTTCAGCTT
GCGAAGGCCCGAGGCGCACATGTCACCGCGATGGCGTCCGCTCGAAACGAGGAGTATGTCCGCAGCCTCGGCGCCGACGA
GTTCGTCGATTACACCAGGCAGCCTTTCGAAAACAGCGTTCGTGACATGGACGTCGTCTTTGACACGGTTGGAGGCGAGA
CATTCAAGCGAGCATTCACCACCCTGAGGCAGGATGGCTTCCTGGTGACGGCGGTCGCCTTTCCTTCTGACGAAGACAAG
CAGCATGGCGTCGGCGTTGCCAGGGTGCAGTGCGTGCCAAATTCGCAGGAACTCACGCAAATCCGGGAATTGATAGAAGC
AGGTAAGGTGAAGCCTTACGTCGCCACTGTCCTTCCGTTCGAGAGCGTCAAGGAGGCGCTTGAATTTTCCGAAGACGGGC
ATACTCGTGGCAAAATCGTCCTGCAAATCGCATGA

Upstream 100 bases:

>100_bases
GGCGATGGAGATTGGCAGAACATCGATAAGGTGTTCGTCTAGCATAGGACTTGTCGATGGTCGAGCCGACACCAAAACCT
CAACAACCGAGAGCGAAGAC

Downstream 100 bases:

>100_bases
TGTGGCCCAATTATAACGACCTCTTTCAATCCAGGCCATGAGGGCGACTGCGCATACGGCAAGGCCGTTCAGGCAAAACT
GGGTGAGTTAATCCTGACCA

Product: zinc-binding oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKAIIINEYGDNSVLKYADVKDPEPKAGEVLVKVHAAGVNPVDWKIRSGAGQRMGMTLPIHLGGEIAGIVEKLGPGVTEF
NRGDGVYGVIKQGGFAQYAIANTTDVARKPSTLDFIETAATPLGALTAWQAMFDVAKLSTGQHVFITNSSGGVGSLAVQL
AKARGAHVTAMASARNEEYVRSLGADEFVDYTRQPFENSVRDMDVVFDTVGGETFKRAFTTLRQDGFLVTAVAFPSDEDK
QHGVGVARVQCVPNSQELTQIRELIEAGKVKPYVATVLPFESVKEALEFSEDGHTRGKIVLQIA

Sequences:

>Translated_304_residues
MKAIIINEYGDNSVLKYADVKDPEPKAGEVLVKVHAAGVNPVDWKIRSGAGQRMGMTLPIHLGGEIAGIVEKLGPGVTEF
NRGDGVYGVIKQGGFAQYAIANTTDVARKPSTLDFIETAATPLGALTAWQAMFDVAKLSTGQHVFITNSSGGVGSLAVQL
AKARGAHVTAMASARNEEYVRSLGADEFVDYTRQPFENSVRDMDVVFDTVGGETFKRAFTTLRQDGFLVTAVAFPSDEDK
QHGVGVARVQCVPNSQELTQIRELIEAGKVKPYVATVLPFESVKEALEFSEDGHTRGKIVLQIA
>Mature_304_residues
MKAIIINEYGDNSVLKYADVKDPEPKAGEVLVKVHAAGVNPVDWKIRSGAGQRMGMTLPIHLGGEIAGIVEKLGPGVTEF
NRGDGVYGVIKQGGFAQYAIANTTDVARKPSTLDFIETAATPLGALTAWQAMFDVAKLSTGQHVFITNSSGGVGSLAVQL
AKARGAHVTAMASARNEEYVRSLGADEFVDYTRQPFENSVRDMDVVFDTVGGETFKRAFTTLRQDGFLVTAVAFPSDEDK
QHGVGVARVQCVPNSQELTQIRELIEAGKVKPYVATVLPFESVKEALEFSEDGHTRGKIVLQIA

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=357, Percent_Identity=33.8935574229692, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI194239674, Length=323, Percent_Identity=29.1021671826625, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI13236495, Length=323, Percent_Identity=29.1021671826625, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI194239676, Length=305, Percent_Identity=31.1475409836066, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI24308257, Length=340, Percent_Identity=25, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI18379349, Length=309, Percent_Identity=25.2427184466019, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI22538446, Length=344, Percent_Identity=26.1627906976744, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI22538444, Length=344, Percent_Identity=26.1627906976744, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI28557745, Length=263, Percent_Identity=25.8555133079848, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790485, Length=237, Percent_Identity=28.2700421940928, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71987554, Length=341, Percent_Identity=27.5659824046921, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17507255, Length=203, Percent_Identity=31.5270935960591, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=240, Percent_Identity=31.25, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=215, Percent_Identity=30.2325581395349, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=224, Percent_Identity=29.9107142857143, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=222, Percent_Identity=30.1801801801802, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=222, Percent_Identity=29.7297297297297, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323493, Length=303, Percent_Identity=26.4026402640264, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319945, Length=269, Percent_Identity=27.1375464684015, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581339, Length=362, Percent_Identity=27.6243093922652, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24581341, Length=362, Percent_Identity=27.6243093922652, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 32642; Mature: 32642

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIIINEYGDNSVLKYADVKDPEPKAGEVLVKVHAAGVNPVDWKIRSGAGQRMGMTLPI
CCEEEEEECCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCEEEEE
HLGGEIAGIVEKLGPGVTEFNRGDGVYGVIKQGGFAQYAIANTTDVARKPSTLDFIETAA
EECCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHCCCCHHHHHHHHC
TPLGALTAWQAMFDVAKLSTGQHVFITNSSGGVGSLAVQLAKARGAHVTAMASARNEEYV
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEHHCCCHHHH
RSLGADEFVDYTRQPFENSVRDMDVVFDTVGGETFKRAFTTLRQDGFLVTAVAFPSDEDK
HHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEECCCCCCC
QHGVGVARVQCVPNSQELTQIRELIEAGKVKPYVATVLPFESVKEALEFSEDGHTRGKIV
CCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCCCCEEE
LQIA
EEEC
>Mature Secondary Structure
MKAIIINEYGDNSVLKYADVKDPEPKAGEVLVKVHAAGVNPVDWKIRSGAGQRMGMTLPI
CCEEEEEECCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCEEEEE
HLGGEIAGIVEKLGPGVTEFNRGDGVYGVIKQGGFAQYAIANTTDVARKPSTLDFIETAA
EECCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHCCCCHHHHHHHHC
TPLGALTAWQAMFDVAKLSTGQHVFITNSSGGVGSLAVQLAKARGAHVTAMASARNEEYV
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEHHCCCHHHH
RSLGADEFVDYTRQPFENSVRDMDVVFDTVGGETFKRAFTTLRQDGFLVTAVAFPSDEDK
HHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEECCCCCCC
QHGVGVARVQCVPNSQELTQIRELIEAGKVKPYVATVLPFESVKEALEFSEDGHTRGKIV
CCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCCCCEEE
LQIA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]