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The map label for this gene is hexR [H]

Identifier: 222102664

GI number: 222102664

Start: 306321

End: 307262

Strand: Reverse

Name: hexR [H]

Synonym: Avi_7330

Alternate gene names: 222102664

Gene position: 307262-306321 (Counterclockwise)

Preceding gene: 222102666

Following gene: 222102663

Centisome position: 48.63

GC content: 58.6

Gene sequence:

>942_bases
TTGGACATTGAAAGCGTACCATCAGCGCAAGAGCGCATGCCAATGTCCCAACGCATCATCCAGGCCACGTTATCGCCCGC
CCACCGGCAGATCGCAGATTACGTGCTGGATTATCCCTTGCGCGTTGCCGCCATGCGGGCTGAAGAATTGGCCGAGATCG
TTCATGTGTCGGTTCCAACCGTCAATCGCTTTGCCCGCGCCTTGGGGTTTGCGGGTTATGCGCAATTTCGTGCTGATCTG
GTGCTGGGGTACGAGACGGCTTTGGCACCTGTGGAAAAATTACAGCGACGGTCGCAGGCGGCAACCAGCCCCGCAGATGT
GTTTGCCAACAACCTGGCCATGATAACCAGAAATATTGAGCGAACCCATCAGGCTCTCGATACCGAGACGCTATCGCGGG
CTATCGGTCTCATTTTGTCCGCCCGCCGCATTTCCATCATCGGCCTTGGCAGCAGCGCCTGGCTTGGCGGCCTTATGCAG
CGGCGGTTTGATCTGTTTTGTGATGATGTTCGCCTGCTGGCAACCGTGGAAGGCGCATCCTTCGCAGCGCGGGCTTTGCG
AAATGTTCGCGCCGGGGACCTCGTCATAGCCATCGCCTTTCCACGCTACATGGCCGATACGGTGACGCTGGCAAAACGCA
TGCGCGATGCTGGGGCCGATGTTCTGGCACTGACAGACAATGCCAGCTCGCCTCTGGTGGCGCATGCCACAATGACGCTG
TTTGCGCAGGTCGAGAGCGATTATTTCGCCAGCTGTGAAGCCAGTGCGCTAGCCTTGATCGAGTCTCTCTCTGCCGCCGT
GTCCTATGCATCAGGCCGTTCCATGCAAGCCGCCACCCAGCTTGTTGATACCGTGCTTCCCTATCTGCACAGCGGTCCAA
ACCACCCTCATCGGGCATCGGCGAAACCGTCAGCCGAAGACGACGAACCCGAGCTTGACTGA

Upstream 100 bases:

>100_bases
ATCATATGCACTTGCCTAGAATTACACCAAAATCCGCTTGAACGATTGAAAAATATCTATACTGAGGCTCAGGTGATATT
TTTTAATCAGGGCCTGCATC

Downstream 100 bases:

>100_bases
TGCCTTGTCTGACCCATTTTCATTGAGACGATCTGCCATGACCTCTTCTGCGACCCTGCCCCAAACCGCACCCTCTCTGC
TAGACAATCAGGTTCTGGCG

Product: transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MDIESVPSAQERMPMSQRIIQATLSPAHRQIADYVLDYPLRVAAMRAEELAEIVHVSVPTVNRFARALGFAGYAQFRADL
VLGYETALAPVEKLQRRSQAATSPADVFANNLAMITRNIERTHQALDTETLSRAIGLILSARRISIIGLGSSAWLGGLMQ
RRFDLFCDDVRLLATVEGASFAARALRNVRAGDLVIAIAFPRYMADTVTLAKRMRDAGADVLALTDNASSPLVAHATMTL
FAQVESDYFASCEASALALIESLSAAVSYASGRSMQAATQLVDTVLPYLHSGPNHPHRASAKPSAEDDEPELD

Sequences:

>Translated_313_residues
MDIESVPSAQERMPMSQRIIQATLSPAHRQIADYVLDYPLRVAAMRAEELAEIVHVSVPTVNRFARALGFAGYAQFRADL
VLGYETALAPVEKLQRRSQAATSPADVFANNLAMITRNIERTHQALDTETLSRAIGLILSARRISIIGLGSSAWLGGLMQ
RRFDLFCDDVRLLATVEGASFAARALRNVRAGDLVIAIAFPRYMADTVTLAKRMRDAGADVLALTDNASSPLVAHATMTL
FAQVESDYFASCEASALALIESLSAAVSYASGRSMQAATQLVDTVLPYLHSGPNHPHRASAKPSAEDDEPELD
>Mature_313_residues
MDIESVPSAQERMPMSQRIIQATLSPAHRQIADYVLDYPLRVAAMRAEELAEIVHVSVPTVNRFARALGFAGYAQFRADL
VLGYETALAPVEKLQRRSQAATSPADVFANNLAMITRNIERTHQALDTETLSRAIGLILSARRISIIGLGSSAWLGGLMQ
RRFDLFCDDVRLLATVEGASFAARALRNVRAGDLVIAIAFPRYMADTVTLAKRMRDAGADVLALTDNASSPLVAHATMTL
FAQVESDYFASCEASALALIESLSAAVSYASGRSMQAATQLVDTVLPYLHSGPNHPHRASAKPSAEDDEPELD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=231, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788767, Length=231, Percent_Identity=25.974025974026, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 33871; Mature: 33871

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIESVPSAQERMPMSQRIIQATLSPAHRQIADYVLDYPLRVAAMRAEELAEIVHVSVPT
CCCCCCCCHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
VNRFARALGFAGYAQFRADLVLGYETALAPVEKLQRRSQAATSPADVFANNLAMITRNIE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RTHQALDTETLSRAIGLILSARRISIIGLGSSAWLGGLMQRRFDLFCDDVRLLATVEGAS
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHEEEECCHH
FAARALRNVRAGDLVIAIAFPRYMADTVTLAKRMRDAGADVLALTDNASSPLVAHATMTL
HHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
FAQVESDYFASCEASALALIESLSAAVSYASGRSMQAATQLVDTVLPYLHSGPNHPHRAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
AKPSAEDDEPELD
CCCCCCCCCCCCC
>Mature Secondary Structure
MDIESVPSAQERMPMSQRIIQATLSPAHRQIADYVLDYPLRVAAMRAEELAEIVHVSVPT
CCCCCCCCHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
VNRFARALGFAGYAQFRADLVLGYETALAPVEKLQRRSQAATSPADVFANNLAMITRNIE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RTHQALDTETLSRAIGLILSARRISIIGLGSSAWLGGLMQRRFDLFCDDVRLLATVEGAS
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHEEEECCHH
FAARALRNVRAGDLVIAIAFPRYMADTVTLAKRMRDAGADVLALTDNASSPLVAHATMTL
HHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
FAQVESDYFASCEASALALIESLSAAVSYASGRSMQAATQLVDTVLPYLHSGPNHPHRAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
AKPSAEDDEPELD
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]