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The map label for this gene is serA [H]

Identifier: 222102472

GI number: 222102472

Start: 69942

End: 70892

Strand: Reverse

Name: serA [H]

Synonym: Avi_7079

Alternate gene names: 222102472

Gene position: 70892-69942 (Counterclockwise)

Preceding gene: 222102478

Following gene: 222102471

Centisome position: 11.22

GC content: 60.78

Gene sequence:

>951_bases
GTGACTGGGGCGGAATTGGCACCTGAAGCAACAGAACTTCTTAAACGACATGCAATCGAGATCGTTTATGCGGATGGCTA
CAGCGGCTCGGAAAATCTCGCTGAGATCGCCAAAACACACGCGGTTGATGCGATCCTCGTCAGACAAGGCCAGATAAACG
ATCAGGTCATCGCGTCTTCCTCCCGTCTTCGAGTGATCGCAAAACACGGCAGCGGCGTGGACAATATCGATCTCGACGCC
GCCACTTCCCACAACATCCCGGTTCTGCGCGCCCTCGCCGCTAACGCACAGTCGGTCGCAGAACTTGCGATCACCCTGTC
CGTGACGCTGATGAAAGACATCGGCAGCCTGAGCGACACCGTGAAGGGCGGCGCTTGGCCGAAGACGAAATATGTCGGAC
GCGACCTCGCGGGCGCCTGCTTCGGCATCATCGGTTTTGGCGAGATCGGGCGCAGGACGGCGAAACTTGCGCAAGGCCTC
GGTATGGAAACCATCGCATACGACCCGTTTGCGGAGGACGCAGATGGCACGCGCGTGAGCCGCGACCTGTCGGACATCCT
CGCGCAAAGCGATATCGTCAGCCTGCATTGCCCGCTGACACCGCAGACCCATCACCTCATCAATGCCGAGCGGCTGAAGG
TGATGAAATCCACGGCCTTCATCGTCAACACGTCGCGCGGCGCCGTCATCGATGAGGCGGCTCTTCTGGATGCACTGAAG
GACGGCAGCATCGCAGGTGCGGCACTCGACAGTTTCGAGCAGGAACCACCGGCTGCCGATCACCCGTTCTGGGCGCTGCC
AAACCTGATCGCCACCCCTCACGTGGGCGGGGCAAGCCGATCAGCGCTGAGGAACATGGCGCTACAGAGCGCGCAGCACA
TCGTCGATGTCCTCACCGGCGCGCCCTTTGATCGTCGGGCACTCGCCAACCAGAACCTCGCCCAGAACTAA

Upstream 100 bases:

>100_bases
GCGACGCACCGGAGTTCGGGAGGGTTTAGTGAACAAAATCAATGCAGCGGAAGCTGCTGCAAACCTATCAACGGCGATTG
CGAGAGGTCTCAAAGTTCTT

Downstream 100 bases:

>100_bases
ACCACCAAATTTGAAAACGGAGGAATCGAAATGTTGGGTTTCAGAGTATGCAAGCGTAAGCAAAATGTCTGCGCGGAATG
GGTGGAGAAATTCAGAACTC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTGAELAPEATELLKRHAIEIVYADGYSGSENLAEIAKTHAVDAILVRQGQINDQVIASSSRLRVIAKHGSGVDNIDLDA
ATSHNIPVLRALAANAQSVAELAITLSVTLMKDIGSLSDTVKGGAWPKTKYVGRDLAGACFGIIGFGEIGRRTAKLAQGL
GMETIAYDPFAEDADGTRVSRDLSDILAQSDIVSLHCPLTPQTHHLINAERLKVMKSTAFIVNTSRGAVIDEAALLDALK
DGSIAGAALDSFEQEPPAADHPFWALPNLIATPHVGGASRSALRNMALQSAQHIVDVLTGAPFDRRALANQNLAQN

Sequences:

>Translated_316_residues
MTGAELAPEATELLKRHAIEIVYADGYSGSENLAEIAKTHAVDAILVRQGQINDQVIASSSRLRVIAKHGSGVDNIDLDA
ATSHNIPVLRALAANAQSVAELAITLSVTLMKDIGSLSDTVKGGAWPKTKYVGRDLAGACFGIIGFGEIGRRTAKLAQGL
GMETIAYDPFAEDADGTRVSRDLSDILAQSDIVSLHCPLTPQTHHLINAERLKVMKSTAFIVNTSRGAVIDEAALLDALK
DGSIAGAALDSFEQEPPAADHPFWALPNLIATPHVGGASRSALRNMALQSAQHIVDVLTGAPFDRRALANQNLAQN
>Mature_315_residues
TGAELAPEATELLKRHAIEIVYADGYSGSENLAEIAKTHAVDAILVRQGQINDQVIASSSRLRVIAKHGSGVDNIDLDAA
TSHNIPVLRALAANAQSVAELAITLSVTLMKDIGSLSDTVKGGAWPKTKYVGRDLAGACFGIIGFGEIGRRTAKLAQGLG
METIAYDPFAEDADGTRVSRDLSDILAQSDIVSLHCPLTPQTHHLINAERLKVMKSTAFIVNTSRGAVIDEAALLDALKD
GSIAGAALDSFEQEPPAADHPFWALPNLIATPHVGGASRSALRNMALQSAQHIVDVLTGAPFDRRALANQNLAQN

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=299, Percent_Identity=34.1137123745819, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI145580578, Length=306, Percent_Identity=34.640522875817, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4557499, Length=306, Percent_Identity=34.640522875817, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI61743967, Length=292, Percent_Identity=34.2465753424658, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4557497, Length=292, Percent_Identity=34.2465753424658, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI145580575, Length=292, Percent_Identity=34.9315068493151, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI6912396, Length=253, Percent_Identity=32.0158102766798, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1789279, Length=304, Percent_Identity=33.5526315789474, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87082289, Length=266, Percent_Identity=32.7067669172932, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=36.2244897959184, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87081824, Length=231, Percent_Identity=26.4069264069264, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788660, Length=110, Percent_Identity=32.7272727272727, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=33.1147540983607, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25147481, Length=293, Percent_Identity=30.3754266211604, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=300, Percent_Identity=34, Blast_Score=155, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=270, Percent_Identity=33.7037037037037, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324055, Length=270, Percent_Identity=31.1111111111111, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=278, Percent_Identity=27.6978417266187, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=205, Percent_Identity=28.780487804878, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=168, Percent_Identity=32.7380952380952, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=164, Percent_Identity=28.6585365853659, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921140, Length=293, Percent_Identity=34.4709897610922, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24646446, Length=287, Percent_Identity=35.8885017421603, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646448, Length=287, Percent_Identity=35.8885017421603, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646452, Length=287, Percent_Identity=35.8885017421603, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646450, Length=287, Percent_Identity=35.8885017421603, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62472511, Length=287, Percent_Identity=35.8885017421603, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=27.2151898734177, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585516, Length=306, Percent_Identity=27.1241830065359, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28574284, Length=316, Percent_Identity=27.8481012658228, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45551003, Length=316, Percent_Identity=27.8481012658228, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585514, Length=316, Percent_Identity=27.8481012658228, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574282, Length=316, Percent_Identity=27.8481012658228, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552429, Length=316, Percent_Identity=27.8481012658228, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28571528, Length=266, Percent_Identity=28.1954887218045, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33335; Mature: 33204

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGAELAPEATELLKRHAIEIVYADGYSGSENLAEIAKTHAVDAILVRQGQINDQVIASS
CCCCCCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHCCC
SRLRVIAKHGSGVDNIDLDAATSHNIPVLRALAANAQSVAELAITLSVTLMKDIGSLSDT
CCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VKGGAWPKTKYVGRDLAGACFGIIGFGEIGRRTAKLAQGLGMETIAYDPFAEDADGTRVS
HCCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHH
RDLSDILAQSDIVSLHCPLTPQTHHLINAERLKVMKSTAFIVNTSRGAVIDEAALLDALK
HHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHC
DGSIAGAALDSFEQEPPAADHPFWALPNLIATPHVGGASRSALRNMALQSAQHIVDVLTG
CCCCHHHHHHHHCCCCCCCCCCCHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
APFDRRALANQNLAQN
CCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TGAELAPEATELLKRHAIEIVYADGYSGSENLAEIAKTHAVDAILVRQGQINDQVIASS
CCCCCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHCCC
SRLRVIAKHGSGVDNIDLDAATSHNIPVLRALAANAQSVAELAITLSVTLMKDIGSLSDT
CCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VKGGAWPKTKYVGRDLAGACFGIIGFGEIGRRTAKLAQGLGMETIAYDPFAEDADGTRVS
HCCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHH
RDLSDILAQSDIVSLHCPLTPQTHHLINAERLKVMKSTAFIVNTSRGAVIDEAALLDALK
HHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHC
DGSIAGAALDSFEQEPPAADHPFWALPNLIATPHVGGASRSALRNMALQSAQHIVDVLTG
CCCCHHHHHHHHCCCCCCCCCCCHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
APFDRRALANQNLAQN
CCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]