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The map label for this gene is panF [H]

Identifier: 222097006

GI number: 222097006

Start: 3291685

End: 3293118

Strand: Reverse

Name: panF [H]

Synonym: BCQ_3346

Alternate gene names: 222097006

Gene position: 3293118-3291685 (Counterclockwise)

Preceding gene: 222097007

Following gene: 222097005

Centisome position: 63.16

GC content: 37.38

Gene sequence:

>1434_bases
ATGAATTGGTATGTAATCATTCCAATGATAATTTCGTTTATCGTTGTATTTTTAATTGGTGTATATGCTTCAAGACGTGT
ACAAGCGACTGCCCATAATAAATTTTTGCAAGAATATTTTTTAGGTGGGCGTGAGCTCGGTGGTTTATTATTAGCAATGA
CAATGATTGCTACGTACGGTAGTGCTAGTAGCTTCATTGGTGGCCCTGGTATAGCATACAATATGGGGCTTGGATGGGTA
TTGTTATCTGCGATTCAAGTTGTAACAGGGTATATCGTTTTAACGGTTATCGGTAAAAAGTTTGCAATTATCGCTAGGAA
GATGGAAGCCATTACTCTTATTGATTATTTAAAGGGAAGATATAATAATAAAGCAGTTGTCATACTTTCTGCGTTATGTA
TTATTATCTTTTTATTTTCAGCAACAGTAGCTCAGTGGGTCGGCGGTGGCCGATTAATTGAGTCGCTAACGGGTCTCTCT
TATACAACAGCACTATTTTTATTTACTTTTTCTGTACTTGTGTACGTATTAATTGGTGGATTTCGTGCAGTTGCTCTATC
AGATACATTATTAGGTATCATTATGTTAGTTGGAACGACAATCATTTTAATTGCTACTGTCATTGCCGGTGGTGGAATTG
AAAAGATTATGCAGGAACTTGTTCAAATCAATCCAAATTTAATTACACCATTCGGAGCGGATGGTAGTTTAACGAAAACA
TATGTGACATCATTTTGGATTTTAATTGGAATTGGCGTTGTCGGTTTACCGCAAATTAGTGTGCGTGCCATGTCTTATAA
AAATTCAAAAGCGATGCATCAAGCGTTAATAATTGGGACGATTGTTGTGGGTACAATTATGATTGGTATGCATTTAACGG
GTGTGTTCGCACGAGTCGTACTTCCAGGTATAACGGTACCAGATAAAGTAATGCCGCTACTCGCGATGGAGGTGTTACCT
CCCTGGTTAGCTGGAGTTTTCTTAGCTGCACCGATGGCAGCGATTATGTCTACAGTAAACTCGCTATTGTTACTTGTAAG
TTCATCAATCATTAAAGATATATACGTAAATTACATAAATAAAGATGCGGCAGATAGTACGATTAGAAAAGGGAGTTTAT
GGATTACTGCTATCGTAGGACTGCTCGTTTATGCAGCAGCAATTAAACCACCTGATTTTTTAATATGGTTGAATTTATTT
TCTTTCGGTGGATTAGAAGCAGCATTCATTTGGCCGATCGTATTAGGGTTATATTGGAGGAAAGGAAATGCAACAGGAGC
GCTTGCATCTATTTTAGTTGGGGTAAGCTCATATATGTGTATCCATCTTTTCTATCCAAATCCGTTCGGTATACATACAG
TTGTCTTCCCAATTTGTTTTGCGTTTATCGCTTATATCGTTGGAAGTATGAGTGCTGTAAAGAAAACAGTATAG

Upstream 100 bases:

>100_bases
CGTTGGATTTATCGTTATGGTTATTTTACTTAGTTTAGTTGTTCGTTTTGTATTTCAAGATATTTCACTCGATGAGGAAG
AAAAAAGTGAGGAATAATAG

Downstream 100 bases:

>100_bases
GTTAGTGGGAGAACGTAGTCCTTAGAGGACTGCGTTTTTTCGTATAAATTTGTTCTTTTTATTCTGTAATCCTGTGAATA
TTCATAAATTAATAACAATT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKT
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVVLPGITVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYIVGSMSAVKKTV

Sequences:

>Translated_477_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKT
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVVLPGITVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYIVGSMSAVKKTV
>Mature_477_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKT
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVVLPGITVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYIVGSMSAVKKTV

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=446, Percent_Identity=28.47533632287, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI157671931, Length=381, Percent_Identity=21.7847769028871, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI14140236, Length=404, Percent_Identity=23.019801980198, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4507035, Length=346, Percent_Identity=23.4104046242775, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4507031, Length=473, Percent_Identity=23.0443974630021, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI167466278, Length=357, Percent_Identity=21.8487394957983, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI87082237, Length=470, Percent_Identity=48.5106382978723, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1787251, Length=448, Percent_Identity=28.3482142857143, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790503, Length=452, Percent_Identity=24.5575221238938, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790113, Length=474, Percent_Identity=24.6835443037975, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573698, Length=395, Percent_Identity=23.5443037974684, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51350; Mature: 51350

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
SASSFIGGPGIAYNMGLGWVLLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLSYTTALFLFTFSVLVYVLIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCHHHH
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVV
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGITVPDKVMPLLAMEVLPPWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYIN
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLFSFGGLEAAFIWPIVLGLYWR
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHC
KGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYIVGSMSAVKKTV
CCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
SASSFIGGPGIAYNMGLGWVLLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLSYTTALFLFTFSVLVYVLIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPNLITPFGADGSLTKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCHHHH
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTIVVGTIMIGMHLTGVFARVV
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGITVPDKVMPLLAMEVLPPWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYIN
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KDAADSTIRKGSLWITAIVGLLVYAAAIKPPDFLIWLNLFSFGGLEAAFIWPIVLGLYWR
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHC
KGNATGALASILVGVSSYMCIHLFYPNPFGIHTVVFPICFAFIAYIVGSMSAVKKTV
CCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]