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The map label for this gene is hemK [H]

Identifier: 222096949

GI number: 222096949

Start: 3230962

End: 3231615

Strand: Reverse

Name: hemK [H]

Synonym: BCQ_3289

Alternate gene names: 222096949

Gene position: 3231615-3230962 (Counterclockwise)

Preceding gene: 222096950

Following gene: 222096947

Centisome position: 61.98

GC content: 45.57

Gene sequence:

>654_bases
ATGCGAGCCGATGGTTTACCACTTGAATATGTTGTTGGATACGCAAAATTTTGTGGGATGCGGATAGAAGTGGAGCGGGG
TGTTTTTGTGCCTCGTCAACGAACCGAATTTCTTGTTCACCAAGCCGAAGCGCTGTCATGTTTTGGTGATATTGTCGTTG
ATCTCTGTTGTGGTTCAGGTGCTGTCGGTGCAGCTCTAGCGGCAGCTTTAGGAAGAGTTGAATTATATTGTGTTGATATT
GACCCTATTGCGGTACGATGTGCAAGCCGCAATGTAACGAGTTTCGGTGGCCATGTTTTTGAAGGTGATTTGTATAAATC
GTTGCCTCATTCACTTAAAGGCAACGTGAATACCATACTTGCAAACGCACCTTATGTTCCTACTGATGCAATAAAACTGC
TCCCACAGGAAGCTCGCCTATATGAACCAAAGGTGGCGCTTGATGGGGGAGAGGATGGACTTGACATTCAGCGAAGAGTA
GCGAAAGAAGCATTTCTCTGGCTAGCACCTGGAGGTCATCTTTTAATAGAGACGAGCGAAATGCAGGTAGATCAGACCTT
TGAAATCTTTGCTGGTGCTGGGCTTACCACGAAAGTGGCTCGAGATGAGGAATTAGATGCTACTGTTGTTATAGGGTCGA
AAGCTAGTTTTTAG

Upstream 100 bases:

>100_bases
TAACAGGCTTCAGAGCGCGGGGTGTGTTTTCGCAGAAGAAGAGACCAGGTTACTTATTTCAGTAGCCCAAACTCCAGAGG
ACCTCAAGAGAATGGTGGAA

Downstream 100 bases:

>100_bases
CTTAAATTTGTATGTAGCCTTATTCATAAATAAAATGATAATTTTCTAGCAATATATAAATAAAAAACATATGCTTTTAA
TTGAGAAAAGAGATCGAAAA

Product: methyltransferase

Products: NA

Alternate protein names: M.MloHemKP [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MRADGLPLEYVVGYAKFCGMRIEVERGVFVPRQRTEFLVHQAEALSCFGDIVVDLCCGSGAVGAALAAALGRVELYCVDI
DPIAVRCASRNVTSFGGHVFEGDLYKSLPHSLKGNVNTILANAPYVPTDAIKLLPQEARLYEPKVALDGGEDGLDIQRRV
AKEAFLWLAPGGHLLIETSEMQVDQTFEIFAGAGLTTKVARDEELDATVVIGSKASF

Sequences:

>Translated_217_residues
MRADGLPLEYVVGYAKFCGMRIEVERGVFVPRQRTEFLVHQAEALSCFGDIVVDLCCGSGAVGAALAAALGRVELYCVDI
DPIAVRCASRNVTSFGGHVFEGDLYKSLPHSLKGNVNTILANAPYVPTDAIKLLPQEARLYEPKVALDGGEDGLDIQRRV
AKEAFLWLAPGGHLLIETSEMQVDQTFEIFAGAGLTTKVARDEELDATVVIGSKASF
>Mature_217_residues
MRADGLPLEYVVGYAKFCGMRIEVERGVFVPRQRTEFLVHQAEALSCFGDIVVDLCCGSGAVGAALAAALGRVELYCVDI
DPIAVRCASRNVTSFGGHVFEGDLYKSLPHSLKGNVNTILANAPYVPTDAIKLLPQEARLYEPKVALDGGEDGLDIQRRV
AKEAFLWLAPGGHLLIETSEMQVDQTFEIFAGAGLTTKVARDEELDATVVIGSKASF

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=170, Percent_Identity=28.8235294117647, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082085, Length=184, Percent_Identity=33.695652173913, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787463, Length=216, Percent_Identity=28.7037037037037, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582226, Length=188, Percent_Identity=31.9148936170213, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 23361; Mature: 23361

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRADGLPLEYVVGYAKFCGMRIEVERGVFVPRQRTEFLVHQAEALSCFGDIVVDLCCGSG
CCCCCCCHHHHHHHHHHCCEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AVGAALAAALGRVELYCVDIDPIAVRCASRNVTSFGGHVFEGDLYKSLPHSLKGNVNTIL
HHHHHHHHHHCCEEEEEEECCCEEEEECCCCCCCCCCEEEECHHHHHCCHHHCCCCEEEE
ANAPYVPTDAIKLLPQEARLYEPKVALDGGEDGLDIQRRVAKEAFLWLAPGGHLLIETSE
ECCCCCCHHHHHHCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHEEEECCCCEEEEEECC
MQVDQTFEIFAGAGLTTKVARDEELDATVVIGSKASF
CCCCCCEEEHCCCCCEEECCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MRADGLPLEYVVGYAKFCGMRIEVERGVFVPRQRTEFLVHQAEALSCFGDIVVDLCCGSG
CCCCCCCHHHHHHHHHHCCEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AVGAALAAALGRVELYCVDIDPIAVRCASRNVTSFGGHVFEGDLYKSLPHSLKGNVNTIL
HHHHHHHHHHCCEEEEEEECCCEEEEECCCCCCCCCCEEEECHHHHHCCHHHCCCCEEEE
ANAPYVPTDAIKLLPQEARLYEPKVALDGGEDGLDIQRRVAKEAFLWLAPGGHLLIETSE
ECCCCCCHHHHHHCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHEEEECCCCEEEEEECC
MQVDQTFEIFAGAGLTTKVARDEELDATVVIGSKASF
CCCCCCEEEHCCCCCEEECCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]