Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 222096609

GI number: 222096609

Start: 2880889

End: 2881707

Strand: Reverse

Name: proC [H]

Synonym: BCQ_2949

Alternate gene names: 222096609

Gene position: 2881707-2880889 (Counterclockwise)

Preceding gene: 222096610

Following gene: 222096608

Centisome position: 55.27

GC content: 33.7

Gene sequence:

>819_bases
ATGAATAAACAAATCGGATTCATCGGATGTGGAAACATGGGTATTGCTATGATAGGTGGGATGATTAAAAAAAATATAGT
TTCTCCAGATCAAATAATTTGTTCAGATTTAAACGTCATTAATTTAAAAAATGCTAGTAATGAATATGGCATAACTATAA
CTACTAACAACAATGAAGTCGCTAACAGTGCTGACATTTTAATTTTATCAATCAAACCAGATTTATACTCATCGGTAATT
AACCAAATAAAAGATCAAATAAAAAATGATGTAATCGTTGTAACTATTGCTGCAGGAAAAAGTATTAAGAGCACTGAGAA
TGAATTTGGTAGAAAGTTAAAAGTTGTTAGAGTAATGCCTAATACACCGGCACTTGTTGGAGAAGGAATGTCTGCGTTAT
GTTTTAATGAAATGGTTACAGAAAAAGATATAAAAGAGGTACTGAACATATTTAATATTTTCGGCCAGACGGAGGTCGTA
AATGAAAAACTAATGGATGTTGTTACATCTATTAGTGGTTCTTCTCCAGCATATGTGTATATGTTTATAGAAGCCATGGC
AGATGCTGCTGTACTTGGCGGTATGCCGAGAAAACAAGCTTATAAATTTGCGGCTCAGGCTGTATTAGGTTCTGCAAAAA
TGGTATTGGAAACAGGAATACATCCAGGTGAATTAAAGGATATGGTTTGTTCTCCAGGTGGAACGACGATAGAAGCTGTA
GTAACGCTAGAAGAAAAAGGTTTAAGAACAGCTATCATTTCAGCTATGAAACGTTGTATGCAAAAATCTATGGAAATGTC
TAGTTTAACTAGTAAGTGA

Upstream 100 bases:

>100_bases
AAATTCTATTGATAAACCCAGTAATTGTAATAACCCTTATTTAGAATAATAATTTCAAAATCAATAAAATTTAGAGTAGA
AGGAGCAAGAGCAAATTATT

Downstream 100 bases:

>100_bases
GAAGCGAATTTATATAATATTTCAAATCTATTTAATGTAAAAGAAATATTATGAGGCTAGTTAATAACTAAGTAAATTTA
TATACAACACTAACGAGACG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MNKQIGFIGCGNMGIAMIGGMIKKNIVSPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIKPDLYSSVI
NQIKDQIKNDVIVVTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVV
NEKLMDVVTSISGSSPAYVYMFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
VTLEEKGLRTAIISAMKRCMQKSMEMSSLTSK

Sequences:

>Translated_272_residues
MNKQIGFIGCGNMGIAMIGGMIKKNIVSPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIKPDLYSSVI
NQIKDQIKNDVIVVTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVV
NEKLMDVVTSISGSSPAYVYMFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
VTLEEKGLRTAIISAMKRCMQKSMEMSSLTSK
>Mature_272_residues
MNKQIGFIGCGNMGIAMIGGMIKKNIVSPDQIICSDLNVINLKNASNEYGITITTNNNEVANSADILILSIKPDLYSSVI
NQIKDQIKNDVIVVTIAAGKSIKSTENEFGRKLKVVRVMPNTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVV
NEKLMDVVTSISGSSPAYVYMFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
VTLEEKGLRTAIISAMKRCMQKSMEMSSLTSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=36.2637362637363, Blast_Score=177, Evalue=9e-45,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=34.4322344322344, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=34.4322344322344, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=34.7014925373134, Blast_Score=172, Evalue=3e-43,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=54.6816479400749, Blast_Score=301, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17569021, Length=261, Percent_Identity=37.5478927203065, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=33.6842105263158, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320861, Length=277, Percent_Identity=29.2418772563177, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=37.4545454545455, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=36.9811320754717, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=43.1952662721894, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29285; Mature: 29285

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQIGFIGCGNMGIAMIGGMIKKNIVSPDQIICSDLNVINLKNASNEYGITITTNNNEV
CCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCCCEEEEECCCCC
ANSADILILSIKPDLYSSVINQIKDQIKNDVIVVTIAAGKSIKSTENEFGRKLKVVRVMP
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHCCEEEEEEECC
NTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVVNEKLMDVVTSISGSSPAYVY
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEE
MFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEE
VTLEEKGLRTAIISAMKRCMQKSMEMSSLTSK
EEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKQIGFIGCGNMGIAMIGGMIKKNIVSPDQIICSDLNVINLKNASNEYGITITTNNNEV
CCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCCCEEEEECCCCC
ANSADILILSIKPDLYSSVINQIKDQIKNDVIVVTIAAGKSIKSTENEFGRKLKVVRVMP
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHCCEEEEEEECC
NTPALVGEGMSALCFNEMVTEKDIKEVLNIFNIFGQTEVVNEKLMDVVTSISGSSPAYVY
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEE
MFIEAMADAAVLGGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEE
VTLEEKGLRTAIISAMKRCMQKSMEMSSLTSK
EEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]