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The map label for this gene is pbp2 [H]

Identifier: 222096558

GI number: 222096558

Start: 2832465

End: 2834618

Strand: Reverse

Name: pbp2 [H]

Synonym: BCQ_2898

Alternate gene names: 222096558

Gene position: 2834618-2832465 (Counterclockwise)

Preceding gene: 222096560

Following gene: 222096557

Centisome position: 54.36

GC content: 36.17

Gene sequence:

>2154_bases
ATGAGACAGAAAAAGGAGCAGAAGAAACAATCGAAAAAGAAAAAGACTCATATTCCTTTTCGGTTAAATGTACTATTTTT
TATCGTCTTTCTTTTATTTTCAGCTATTATAATTCAATTAGGTAAAGTACAAATCATTGATGGAGAAACGTATAGAAATG
AAGTGAACAAAAAGGAAGATGTAACGGTAAGTACACCTGTTCCTAGAGGGAAAATGTTTGATCGACAAGGTCAGGTGATT
GTAAATAATAAACCACTACGAACCGTTACATATACGAAAATGAAAGGAGTAGATTCGAAAGAAGTTTTACAAGTAGCAAG
ACAGTTAGCCCAGTTAATTGAAATGTCGCCAGAGGATATAGACAAGTTAACAGAAACAGATAAAAAGGATTTTTGGATGC
AGTTAAATGAAAAGCGGGCAGCAGAAAAAGTAACGAAAGAAGATGAGAGTAAATTTAGGAAGCAGGAGATAGAAGGGAAA
GAATTAGATAAAAAAGTGGAAGAGTTACGTAGGGAAAGAATTACACAAGAAGAATTAAGCGAACTTTCAAAAGAAGACCT
AGAAGTACTAGCTATTAAAAGCAAAATGAATGCGGGATATAAAATGACGCCGCAAATCGTTAAAAAAGATGTAAGTCAAA
ATGAATATGCAGTCGTAAGTGAAAGATTGGCAAGCTTGCCCGGAGTAGATACGACAGTAGACTGGGAACGTGAATACCCA
AATGATAAAATACTTCGTTCTATTCTTGGTAGCGTTTCTACTGAAAATGAAGGATTGCCAAGGGAACAATTAGATTATTA
TTTAGTGCGTGATTATAACCGAAATGACCGCATTGGTAAGAGTTACATCGAAAAGCAATATGAAGACGCATTACATGGAA
CGAAAGAGCAATCTAGAAGCATTACAGATAAAGCAGGAAATATAATCCGGACAGAAAAAGTGACCGAAGGAAAAAGTGGA
AATAATTTAATGTTAACAGTAGATATGGAGTTACAGAAAAAAGTAGAGGAAAGTCTTGAAAAGAATTTACGAGCATTTCA
TTCTGCAGAGCCGATGATGGATCGTGCATTCGTTGTAATGATGAACCCGAAAAACGGTCAAATTTTATCGATGGCAGGAA
AGAAAATTGTAAATAAAGATGGCGGGATGCAAATAGAGGACTATGCTTTAGGGACAATGACAAGTTCTTATGAGTTAGGG
TCAACTGTGAAAGGGGCTACATTATTAGCCGGCTATCAAACTGACACAATTAAGCCGTATACACATTTCTTTGATGCACC
TATGTATTTTAAAGGAAGCTCTAAGCCGAAGAAATCGTGGAAAGACTTTGGTGATATTGATGATTTAAGAGCTTTACAAG
TTTCATCAAACGTATATATGTTTAATACAGCATTAAAGATGGCAGGTATAAATTATGTGCCAAACAATCCATTAGACATT
AAACAAGAGACATTTAATAAAATGCGCTACTATTTTAGACAATTTGGTTTAGGTGTACCGACTGGTATTGACTTGCCGAA
TGAATCGATTGGTCAAATGGGTAGAACGGATAACGTACCTGGTTTTTTACTTGATTATGCGATTGGACAGTACGATACAT
ATACGCCGCTTCAACTTGCTCAATATATTTCAACCATTGCAAACGGTGGTTACAGAATGAAACCGCAAATTGTGCAAGAA
GTGAGAGAACAACCACATAGACCAGAGGATGTTGGAAAAGTTATTCGATCTATTGAACCAGTTATTTTAAATCGAGTGGA
TATGAACACTTCATACATTAATCATGTAAAAGAAGGATTTAGAAGGGTTTTTCAAGAGAATGACGGAACAGGTACTGCAA
CGTTTAAAGGATTACCGTATAAACCAGCTGGAAAAACAGGGACAGCTGAAACTGTGTATGGTGGAGAAAGTGAAATTGGA
AGAGATGAAAACAATAATAGAAAAAAATGTTATAATTTAACTCTTGCCGGTTATGCGCCGTATGATGCTGATCCGGAAGT
AGCTTTTTCAGTTGTTGTACCATGGGTAAATGATGACAAATCAGGAATTAATTCCGCAATTGGTAAAGAGATTTTGGATG
CGTATTTTGAATTGAAAGCGAAAAGAGCAGGTGGAAATCCAGTCCCAGTAGAGCAGCCGAACAAGGCCCAGTAA

Upstream 100 bases:

>100_bases
CTTTTATAATTAATATAAAATTCTATATATATCATATAAATAAATTTGATACATAATGGTTCCATGTAGAAATGTTAATA
GAATGAAGCGAGGGAGCGAA

Downstream 100 bases:

>100_bases
AAATCATATCACTGCATTGAGACATATGGTGCAGTGATATATTTTTTGATTTAAAAAGCGTTTGAATAAGGTGGGAATGG
ATATGAAACAGGAGATTAAA

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MRQKKEQKKQSKKKKTHIPFRLNVLFFIVFLLFSAIIIQLGKVQIIDGETYRNEVNKKEDVTVSTPVPRGKMFDRQGQVI
VNNKPLRTVTYTKMKGVDSKEVLQVARQLAQLIEMSPEDIDKLTETDKKDFWMQLNEKRAAEKVTKEDESKFRKQEIEGK
ELDKKVEELRRERITQEELSELSKEDLEVLAIKSKMNAGYKMTPQIVKKDVSQNEYAVVSERLASLPGVDTTVDWEREYP
NDKILRSILGSVSTENEGLPREQLDYYLVRDYNRNDRIGKSYIEKQYEDALHGTKEQSRSITDKAGNIIRTEKVTEGKSG
NNLMLTVDMELQKKVEESLEKNLRAFHSAEPMMDRAFVVMMNPKNGQILSMAGKKIVNKDGGMQIEDYALGTMTSSYELG
STVKGATLLAGYQTDTIKPYTHFFDAPMYFKGSSKPKKSWKDFGDIDDLRALQVSSNVYMFNTALKMAGINYVPNNPLDI
KQETFNKMRYYFRQFGLGVPTGIDLPNESIGQMGRTDNVPGFLLDYAIGQYDTYTPLQLAQYISTIANGGYRMKPQIVQE
VREQPHRPEDVGKVIRSIEPVILNRVDMNTSYINHVKEGFRRVFQENDGTGTATFKGLPYKPAGKTGTAETVYGGESEIG
RDENNNRKKCYNLTLAGYAPYDADPEVAFSVVVPWVNDDKSGINSAIGKEILDAYFELKAKRAGGNPVPVEQPNKAQ

Sequences:

>Translated_717_residues
MRQKKEQKKQSKKKKTHIPFRLNVLFFIVFLLFSAIIIQLGKVQIIDGETYRNEVNKKEDVTVSTPVPRGKMFDRQGQVI
VNNKPLRTVTYTKMKGVDSKEVLQVARQLAQLIEMSPEDIDKLTETDKKDFWMQLNEKRAAEKVTKEDESKFRKQEIEGK
ELDKKVEELRRERITQEELSELSKEDLEVLAIKSKMNAGYKMTPQIVKKDVSQNEYAVVSERLASLPGVDTTVDWEREYP
NDKILRSILGSVSTENEGLPREQLDYYLVRDYNRNDRIGKSYIEKQYEDALHGTKEQSRSITDKAGNIIRTEKVTEGKSG
NNLMLTVDMELQKKVEESLEKNLRAFHSAEPMMDRAFVVMMNPKNGQILSMAGKKIVNKDGGMQIEDYALGTMTSSYELG
STVKGATLLAGYQTDTIKPYTHFFDAPMYFKGSSKPKKSWKDFGDIDDLRALQVSSNVYMFNTALKMAGINYVPNNPLDI
KQETFNKMRYYFRQFGLGVPTGIDLPNESIGQMGRTDNVPGFLLDYAIGQYDTYTPLQLAQYISTIANGGYRMKPQIVQE
VREQPHRPEDVGKVIRSIEPVILNRVDMNTSYINHVKEGFRRVFQENDGTGTATFKGLPYKPAGKTGTAETVYGGESEIG
RDENNNRKKCYNLTLAGYAPYDADPEVAFSVVVPWVNDDKSGINSAIGKEILDAYFELKAKRAGGNPVPVEQPNKAQ
>Mature_717_residues
MRQKKEQKKQSKKKKTHIPFRLNVLFFIVFLLFSAIIIQLGKVQIIDGETYRNEVNKKEDVTVSTPVPRGKMFDRQGQVI
VNNKPLRTVTYTKMKGVDSKEVLQVARQLAQLIEMSPEDIDKLTETDKKDFWMQLNEKRAAEKVTKEDESKFRKQEIEGK
ELDKKVEELRRERITQEELSELSKEDLEVLAIKSKMNAGYKMTPQIVKKDVSQNEYAVVSERLASLPGVDTTVDWEREYP
NDKILRSILGSVSTENEGLPREQLDYYLVRDYNRNDRIGKSYIEKQYEDALHGTKEQSRSITDKAGNIIRTEKVTEGKSG
NNLMLTVDMELQKKVEESLEKNLRAFHSAEPMMDRAFVVMMNPKNGQILSMAGKKIVNKDGGMQIEDYALGTMTSSYELG
STVKGATLLAGYQTDTIKPYTHFFDAPMYFKGSSKPKKSWKDFGDIDDLRALQVSSNVYMFNTALKMAGINYVPNNPLDI
KQETFNKMRYYFRQFGLGVPTGIDLPNESIGQMGRTDNVPGFLLDYAIGQYDTYTPLQLAQYISTIANGGYRMKPQIVQE
VREQPHRPEDVGKVIRSIEPVILNRVDMNTSYINHVKEGFRRVFQENDGTGTATFKGLPYKPAGKTGTAETVYGGESEIG
RDENNNRKKCYNLTLAGYAPYDADPEVAFSVVVPWVNDDKSGINSAIGKEILDAYFELKAKRAGGNPVPVEQPNKAQ

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=714, Percent_Identity=23.8095238095238, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786272, Length=462, Percent_Identity=24.6753246753247, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 81475; Mature: 81475

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQKKEQKKQSKKKKTHIPFRLNVLFFIVFLLFSAIIIQLGKVQIIDGETYRNEVNKKED
CCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCCC
VTVSTPVPRGKMFDRQGQVIVNNKPLRTVTYTKMKGVDSKEVLQVARQLAQLIEMSPEDI
EEEECCCCCCCCCCCCCCEEECCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCHHHH
DKLTETDKKDFWMQLNEKRAAEKVTKEDESKFRKQEIEGKELDKKVEELRRERITQEELS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHH
ELSKEDLEVLAIKSKMNAGYKMTPQIVKKDVSQNEYAVVSERLASLPGVDTTVDWEREYP
HHHHHHHHEEEEHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCEECCHHCCC
NDKILRSILGSVSTENEGLPREQLDYYLVRDYNRNDRIGKSYIEKQYEDALHGTKEQSRS
CHHHHHHHHHCCCCCCCCCCHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
ITDKAGNIIRTEKVTEGKSGNNLMLTVDMELQKKVEESLEKNLRAFHSAEPMMDRAFVVM
HHHHCCCEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
MNPKNGQILSMAGKKIVNKDGGMQIEDYALGTMTSSYELGSTVKGATLLAGYQTDTIKPY
ECCCCCCEEECCCHHHHCCCCCCEEEEEEHHCCCCCCCCCCCCCCCEEEECCCCCCCCHH
THFFDAPMYFKGSSKPKKSWKDFGDIDDLRALQVSSNVYMFNTALKMAGINYVPNNPLDI
HHHHCCCEEECCCCCCHHHHHCCCCHHHHHHEEECCCEEEEEHHHHHCCCCCCCCCCCCC
KQETFNKMRYYFRQFGLGVPTGIDLPNESIGQMGRTDNVPGFLLDYAIGQYDTYTPLQLA
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHH
QYISTIANGGYRMKPQIVQEVREQPHRPEDVGKVIRSIEPVILNRVDMNTSYINHVKEGF
HHHHHHHCCCEEECHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHH
RRVFQENDGTGTATFKGLPYKPAGKTGTAETVYGGESEIGRDENNNRKKCYNLTLAGYAP
HHHHHCCCCCCEEEECCCCCCCCCCCCCCCEECCCCHHCCCCCCCCCCEEEEEEEECCCC
YDADPEVAFSVVVPWVNDDKSGINSAIGKEILDAYFELKAKRAGGNPVPVEQPNKAQ
CCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRQKKEQKKQSKKKKTHIPFRLNVLFFIVFLLFSAIIIQLGKVQIIDGETYRNEVNKKED
CCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCCC
VTVSTPVPRGKMFDRQGQVIVNNKPLRTVTYTKMKGVDSKEVLQVARQLAQLIEMSPEDI
EEEECCCCCCCCCCCCCCEEECCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCHHHH
DKLTETDKKDFWMQLNEKRAAEKVTKEDESKFRKQEIEGKELDKKVEELRRERITQEELS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHH
ELSKEDLEVLAIKSKMNAGYKMTPQIVKKDVSQNEYAVVSERLASLPGVDTTVDWEREYP
HHHHHHHHEEEEHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCEECCHHCCC
NDKILRSILGSVSTENEGLPREQLDYYLVRDYNRNDRIGKSYIEKQYEDALHGTKEQSRS
CHHHHHHHHHCCCCCCCCCCHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
ITDKAGNIIRTEKVTEGKSGNNLMLTVDMELQKKVEESLEKNLRAFHSAEPMMDRAFVVM
HHHHCCCEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
MNPKNGQILSMAGKKIVNKDGGMQIEDYALGTMTSSYELGSTVKGATLLAGYQTDTIKPY
ECCCCCCEEECCCHHHHCCCCCCEEEEEEHHCCCCCCCCCCCCCCCEEEECCCCCCCCHH
THFFDAPMYFKGSSKPKKSWKDFGDIDDLRALQVSSNVYMFNTALKMAGINYVPNNPLDI
HHHHCCCEEECCCCCCHHHHHCCCCHHHHHHEEECCCEEEEEHHHHHCCCCCCCCCCCCC
KQETFNKMRYYFRQFGLGVPTGIDLPNESIGQMGRTDNVPGFLLDYAIGQYDTYTPLQLA
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHH
QYISTIANGGYRMKPQIVQEVREQPHRPEDVGKVIRSIEPVILNRVDMNTSYINHVKEGF
HHHHHHHCCCEEECHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHH
RRVFQENDGTGTATFKGLPYKPAGKTGTAETVYGGESEIGRDENNNRKKCYNLTLAGYAP
HHHHHCCCCCCEEEECCCCCCCCCCCCCCCEECCCCHHCCCCCCCCCCEEEEEEEECCCC
YDADPEVAFSVVVPWVNDDKSGINSAIGKEILDAYFELKAKRAGGNPVPVEQPNKAQ
CCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]