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The map label for this gene is flp [H]

Identifier: 222095832

GI number: 222095832

Start: 2146007

End: 2147464

Strand: Reverse

Name: flp [H]

Synonym: BCQ_2172

Alternate gene names: 222095832

Gene position: 2147464-2146007 (Counterclockwise)

Preceding gene: 222095839

Following gene: 222095825

Centisome position: 41.18

GC content: 36.01

Gene sequence:

>1458_bases
ATGTCTAAAATTGAAACTCCTGTTATATCTTCTTTGCAAACAACTGTTGAAAAAATGATAAAGGATTTAAAGGTTCCTGG
CGCTGCTGTAGCTGTTATAAAAGACGGTGAAGTCATTATTTCAGAAGGCTTTGGCTATCGTAATTTAGACACAAAAGACC
CTGTTACACCGCGTACTTTGTTCGCAATCGGTTCCTCAACGAAAGCTTTTGGCACACTTTCATTATGTTTGTTAGCACAG
CAAAAAAAGTTTAATTGGGATACTCCTGTCCAGTCTTATATACCTAACTTCTCTTTATCTGAACTACTTGCTAGCTCACA
AGTTACAGGACGAGATTTAGCTTCTCATCGCACTGGGGTAAGTCGTCATGATGCTCTTTGGTATAGCTCTTCCTTATCTC
GAAAAGATCTCGTTGAAAAAATAAAACATTTACCACTTGATGCACCGTTCCGCACAGCATTTCTTTATAACAACTTAATG
TATGCAACAATTAGCTACATTGTTGAAAACATTACAAATCAAACGTGGGAGCAATACGCTACAGAACATATTTTAGATCC
TTTAAATATGAGACATACAAATTTCTCTGTTACAGATTCACAAACTACAGATGATTATGCTTTACCTTACGTTGACAATG
AAGGTGAAATAAAAGAAGTTCCATTCCATAACATCGATACAGTCGGAGCTGCTGGATGTATTAATTCTACAATTGAAGAT
ATGGCCAATTGGGTCCTTCTTCACTTAAACAAAGGTAAATTTGGAGATCATGAATTAATCTCCTCTGAATTATTACAACA
AATGTATATACCGCACAATTCCATTCCAGATCAACCAGTTTTATCACTTCCTGAATCTCCATTAAATAGTTATGGGCTTG
GTTGGTTTATTAGCGCTTATCGTGGGAATAAGGTGATTCATCACGGCGGTAATATTGATGGATTTTCAGCGCTTGTTTCT
TTCATACCAACAGAAAACATCGGCCTTGTCATTTTAACGAATGCTGGAGGCACATTACTGCCTACTTATCTCGCTAATCA
AATTTATGACGAACTACTTGAATTAGAATCCATTGATTGGCATAAACGCGCTGTAGAAGATACTGAAAAAATGAAGGAAA
TGATGAAAGAAGCAACTGAATCCATTCCAGAACAAATTAAAGAAACTACACCTTCTCATAAATTAGAGGATTATACTGGT
GCTTTCGAACATCCGGCATACGGAACATTACAAGTATACGAGCGTGATGATTCATTATTTGTGCAATTCATGGAAATGGA
CATTCAATTAACACATCATCATTACGACATCTTCTCTGCAAAAGTTGATTTATTCCAAATGAAGATGAATCTATTATTTG
CATATGAAATGAGTGTGAACGGTGAATTCCCTTCCCTTCAGTTACATGTACCAGCTACATTAAGTACTCAGCCGCTTACA
TTTAAGAAAATTAAATAA

Upstream 100 bases:

>100_bases
CTTACAAAATTATTAACTTTCCATAATTAAAAAGGTTTTTATTTTCTATTACCGAAAGTATTGTGCGGTAGAACAAAATT
TATATTTGGAGGTTAGAAGT

Downstream 100 bases:

>100_bases
GTATTTTGATGGTAAAAAATAAAGGTAGGTGCGAATCACACCTACCTTTTCTATTTCATATCAATCTTATCTGGTTGAAA
CCAAATTGGCTTCGATAACT

Product: penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSKIETPVISSLQTTVEKMIKDLKVPGAAVAVIKDGEVIISEGFGYRNLDTKDPVTPRTLFAIGSSTKAFGTLSLCLLAQ
QKKFNWDTPVQSYIPNFSLSELLASSQVTGRDLASHRTGVSRHDALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLM
YATISYIVENITNQTWEQYATEHILDPLNMRHTNFSVTDSQTTDDYALPYVDNEGEIKEVPFHNIDTVGAAGCINSTIED
MANWVLLHLNKGKFGDHELISSELLQQMYIPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGFSALVS
FIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTEKMKEMMKEATESIPEQIKETTPSHKLEDYTG
AFEHPAYGTLQVYERDDSLFVQFMEMDIQLTHHHYDIFSAKVDLFQMKMNLLFAYEMSVNGEFPSLQLHVPATLSTQPLT
FKKIK

Sequences:

>Translated_485_residues
MSKIETPVISSLQTTVEKMIKDLKVPGAAVAVIKDGEVIISEGFGYRNLDTKDPVTPRTLFAIGSSTKAFGTLSLCLLAQ
QKKFNWDTPVQSYIPNFSLSELLASSQVTGRDLASHRTGVSRHDALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLM
YATISYIVENITNQTWEQYATEHILDPLNMRHTNFSVTDSQTTDDYALPYVDNEGEIKEVPFHNIDTVGAAGCINSTIED
MANWVLLHLNKGKFGDHELISSELLQQMYIPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGFSALVS
FIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTEKMKEMMKEATESIPEQIKETTPSHKLEDYTG
AFEHPAYGTLQVYERDDSLFVQFMEMDIQLTHHHYDIFSAKVDLFQMKMNLLFAYEMSVNGEFPSLQLHVPATLSTQPLT
FKKIK
>Mature_484_residues
SKIETPVISSLQTTVEKMIKDLKVPGAAVAVIKDGEVIISEGFGYRNLDTKDPVTPRTLFAIGSSTKAFGTLSLCLLAQQ
KKFNWDTPVQSYIPNFSLSELLASSQVTGRDLASHRTGVSRHDALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLMY
ATISYIVENITNQTWEQYATEHILDPLNMRHTNFSVTDSQTTDDYALPYVDNEGEIKEVPFHNIDTVGAAGCINSTIEDM
ANWVLLHLNKGKFGDHELISSELLQQMYIPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGFSALVSF
IPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTEKMKEMMKEATESIPEQIKETTPSHKLEDYTGA
FEHPAYGTLQVYERDDSLFVQFMEMDIQLTHHHYDIFSAKVDLFQMKMNLLFAYEMSVNGEFPSLQLHVPATLSTQPLTF
KKIK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI239747261, Length=381, Percent_Identity=23.8845144356955, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI239752721, Length=381, Percent_Identity=23.8845144356955, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI239741085, Length=381, Percent_Identity=23.8845144356955, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI26051231, Length=124, Percent_Identity=32.258064516129, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI26051233, Length=124, Percent_Identity=32.258064516129, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790593, Length=345, Percent_Identity=27.536231884058, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082101, Length=317, Percent_Identity=22.7129337539432, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17550934, Length=188, Percent_Identity=26.5957446808511, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 54638; Mature: 54506

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIETPVISSLQTTVEKMIKDLKVPGAAVAVIKDGEVIISEGFGYRNLDTKDPVTPRTL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCEE
FAIGSSTKAFGTLSLCLLAQQKKFNWDTPVQSYIPNFSLSELLASSQVTGRDLASHRTGV
EEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHCCCCHHHHHHHHCCC
SRHDALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLMYATISYIVENITNQTWEQYA
CHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEHILDPLNMRHTNFSVTDSQTTDDYALPYVDNEGEIKEVPFHNIDTVGAAGCINSTIED
HHHHCCCCCCCCCCEEECCCCCCCCCCCCEECCCCCEEECCCCCCCCCCHHHHHHHHHHH
MANWVLLHLNKGKFGDHELISSELLQQMYIPHNSIPDQPVLSLPESPLNSYGLGWFISAY
HHCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCHHEEEEE
RGNKVIHHGGNIDGFSALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDW
CCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCH
HKRAVEDTEKMKEMMKEATESIPEQIKETTPSHKLEDYTGAFEHPAYGTLQVYERDDSLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEEECCHHHH
VQFMEMDIQLTHHHYDIFSAKVDLFQMKMNLLFAYEMSVNGEFPSLQLHVPATLSTQPLT
HHHHHHCEEEEEEEHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCCCCCCCE
FKKIK
EECCC
>Mature Secondary Structure 
SKIETPVISSLQTTVEKMIKDLKVPGAAVAVIKDGEVIISEGFGYRNLDTKDPVTPRTL
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCEE
FAIGSSTKAFGTLSLCLLAQQKKFNWDTPVQSYIPNFSLSELLASSQVTGRDLASHRTGV
EEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHCCCCHHHHHHHHCCC
SRHDALWYSSSLSRKDLVEKIKHLPLDAPFRTAFLYNNLMYATISYIVENITNQTWEQYA
CHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEHILDPLNMRHTNFSVTDSQTTDDYALPYVDNEGEIKEVPFHNIDTVGAAGCINSTIED
HHHHCCCCCCCCCCEEECCCCCCCCCCCCEECCCCCEEECCCCCCCCCCHHHHHHHHHHH
MANWVLLHLNKGKFGDHELISSELLQQMYIPHNSIPDQPVLSLPESPLNSYGLGWFISAY
HHCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCHHEEEEE
RGNKVIHHGGNIDGFSALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDW
CCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCH
HKRAVEDTEKMKEMMKEATESIPEQIKETTPSHKLEDYTGAFEHPAYGTLQVYERDDSLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEEECCHHHH
VQFMEMDIQLTHHHYDIFSAKVDLFQMKMNLLFAYEMSVNGEFPSLQLHVPATLSTQPLT
HHHHHHCEEEEEEEHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCCCCCCCE
FKKIK
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA