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The map label for this gene is hisC-1 [H]

Identifier: 222095247

GI number: 222095247

Start: 1558166

End: 1559278

Strand: Direct

Name: hisC-1 [H]

Synonym: BCQ_1587

Alternate gene names: 222095247

Gene position: 1558166-1559278 (Clockwise)

Preceding gene: 222095246

Following gene: 222095248

Centisome position: 29.88

GC content: 35.85

Gene sequence:

>1113_bases
ATGAGAGTAAAAGAACAATTGTTAACTTTGAGAGCATATGTACCTGGGAAAAATATTGAAGAAGTAAAAAGGGAATATGG
ATTATCAAAAATTGTGAAATTAGCATCGAACGAAAATCCATTCGGTTGCTCAGCACGCGTAACAGAAGCATTAACTTCTT
TAGCGAGTCAATACGCTCTTTATCCAGATGGACATGCCTTTGAACTTCGGACACAAGTAGCAAAACATTTAGGTGTTAAA
GCGGAACAACTGTTATTTGGTAGTGGATTAGATGAAGTTATTCAAATGATTAGTCGTGCGTTACTACACGAAGGAACAAA
TGTTGTAATGGCGAATCCAACATTCTCACAATACCATCACCATGCTGTTATTGAAGGAGCAGAAGTTCGTGAAGTACCAC
TTAAAGATGGCGTTCACGATTTAGATGCGATGTTACAGCAAGTAGATGATCAAACGAAGATTGTATGGATTTGTAACCCG
AATAATCCGACAGGTACATATGTAGAAAAACAAAAATTACTTTCATTTTTAGAATCAGTTCCTAAGTCAGCGCTCGTTAT
TATGGACGAAGCATATTATGAATATGCGGGAGCAGAAGACTATCCGCAAACATTACCACTTCTTGAAAAGTATGAAAATC
TTATGGTATTACGTACGTTTTCAAAAGCATATGGTCTAGCTGCTTTCCGTATCGGATATGCAGTTGGTAATACGGAGTTA
ATCGGGCAGCTAGAAGTAGCGAGGTTACCATTTAATACATCGACTGTAGCGCAATCTGTAGCACTTGCTGCATTAGAAGA
TCAAGCATTTTTACAAGAATGTGTGAAAAAGAATGAAGAAGGATTACATCAATATTACGCATTTTGTAAGGAATATAACG
TATTCTATTATCCATCTCAAACAAATTTCATTTTCTTAAAACTCGGTATTCCTGGTAATGAAGCTTTTGAACGATTAATG
AAAAAAGGATATATTGTTCGTTCTGGTGCTGCATTTGGTATCGATGATGGCATTCGTATTACTGTCGGTTTGAAAGAAGA
AAATGATGAAATTATAGAGTTACTGAAAGAACTTGTAAATGAGCAAGTACAGAAAGAGGAAACATATTCTTAA

Upstream 100 bases:

>100_bases
AGAAGCATTTTCGTAATAGTGACAGTTATGATAAACAATTATAGTAAGGGAGTATAACCGTATTGTAATCGAATTGAATA
AAATGACTGGGGGAAGAAAA

Downstream 100 bases:

>100_bases
GAGATTGTGAAGGCTCCTATTAGAGGAGTCTTTTTTATCGCATTAAAAAAGTTGAAGTTTGGTAATTAAGTTGTTCTGTA
AATCAAGATTGGTATGGCTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVPLKDGVHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Sequences:

>Translated_370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVPLKDGVHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS
>Mature_370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVPLKDGVHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=342, Percent_Identity=30.7017543859649, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788722, Length=367, Percent_Identity=26.4305177111717, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788627, Length=239, Percent_Identity=25.1046025104602, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=333, Percent_Identity=30.3303303303303, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41599; Mature: 41599

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYAL
CCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
YPDGHAFELRTQVAKHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHH
CCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHC
HAVIEGAEVREVPLKDGVHDLDAMLQQVDDQTKIVWICNPNNPTGTYVEKQKLLSFLESV
HHHCCCCCCEECCHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
CCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQ
HCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCC
TNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVN
CCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVQKEETYS
HHHHHHHCCC
>Mature Secondary Structure
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYAL
CCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
YPDGHAFELRTQVAKHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHH
CCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHC
HAVIEGAEVREVPLKDGVHDLDAMLQQVDDQTKIVWICNPNNPTGTYVEKQKLLSFLESV
HHHCCCCCCEECCHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
CCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQ
HCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCC
TNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVN
CCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVQKEETYS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]