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The map label for this gene is trpC [H]

Identifier: 222094964

GI number: 222094964

Start: 1291915

End: 1292676

Strand: Direct

Name: trpC [H]

Synonym: BCQ_1302

Alternate gene names: 222094964

Gene position: 1291915-1292676 (Clockwise)

Preceding gene: 222094963

Following gene: 222094965

Centisome position: 24.78

GC content: 35.83

Gene sequence:

>762_bases
GTGGGGACGATTTTAGACAAAATTGTAGATCAAAAGAAAAAGGAAGTTGCGGCATTATATGAAACATATACACCAGTAAA
AGAAAAAAGAAAAACGCGCTCACTTGTAAAGGCTCTAGAGCAATTTACTGTCATTGCAGAAGTAAAGCGAGCATCACCAT
CAAAAGGAGATATTAATTTACATGTTGATGTACGAAAACAAGTGAAGGCATATGAAGAATGCGGCGCTGGTGCAGTTTCT
GTTTTAACAGACGGTCAATTTTTTAAAGGATCATTTTATGATTTACAAACGGCAAGAGAAGAAAGTAGCATTCCGCTTTT
ATGTAAAGATTTCATAATCGATAAGATTCAAATTGATAGAGCGTATGAAGCTGGTGCAGATATTATTTTACTAATCGTAG
CGGCGTTAACGAAAGAGAAATTAAAAGAGTTGTATAGCTACGTACTAGAAAAAGGGTTAGAAGCGATTGTTGAAGTTCAT
GATGAACAGGAATTAGAAATTGCAATTCAATTCAATCCGCACGTTATCGGTATTAACAACCGTAATTTAAAAACATTCGA
AGTCGATTTAAGTCAAACAGAAAAGCTTGGAAAACGATTAAATGAGGAGAAATTACTTTGGATTAGTGAGAGCGGGGTTC
ATTCAAAAGAAGACATGATCCGCGTTAAACGAGCTGGGGCAAAAGGTGTACTAGTTGGAGAAGCGCTTATGACATCGTCT
TCTATTCATACCTTTTTTGAAGATTGTAAGGTGAACATATGA

Upstream 100 bases:

>100_bases
ATAACACTCGCAGCACATAGCATTGACTCTGGAAAAGCATTAGCGAAACTAAACTTATTAATTGCAGCAAGTAACGAAAA
ATTAGAAAGGGTGAATTAAA

Downstream 100 bases:

>100_bases
AAGTGAAAATTTGCGGGATCACTGATATGGAAACAGCAAAACGTGCTTGCGAATACGGAGCTGATGCACTCGGATTTGTT
TTTGCAGAAAGTAAGAGAAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MGTILDKIVDQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKAYEECGAGAVS
VLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVH
DEQELEIAIQFNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGVHSKEDMIRVKRAGAKGVLVGEALMTSS
SIHTFFEDCKVNI

Sequences:

>Translated_253_residues
MGTILDKIVDQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKAYEECGAGAVS
VLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVH
DEQELEIAIQFNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGVHSKEDMIRVKRAGAKGVLVGEALMTSS
SIHTFFEDCKVNI
>Mature_252_residues
GTILDKIVDQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKAYEECGAGAVSV
LTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHD
EQELEIAIQFNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGVHSKEDMIRVKRAGAKGVLVGEALMTSSS
IHTFFEDCKVNI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=253, Percent_Identity=36.3636363636364, Blast_Score=124, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=43.1924882629108, Blast_Score=155, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28446; Mature: 28315

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTILDKIVDQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINL
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
HVDVRKQVKAYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDR
EEEHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQFNPHVIGINN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECC
RNLKTFEVDLSQTEKLGKRLNEEKLLWISESGVHSKEDMIRVKRAGAKGVLVGEALMTSS
CCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHH
SIHTFFEDCKVNI
HHHHHHHHHCCCC
>Mature Secondary Structure 
GTILDKIVDQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINL
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
HVDVRKQVKAYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDR
EEEHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQFNPHVIGINN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECC
RNLKTFEVDLSQTEKLGKRLNEEKLLWISESGVHSKEDMIRVKRAGAKGVLVGEALMTSS
CCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHH
SIHTFFEDCKVNI
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA