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The map label for this gene is hemH [H]

Identifier: 222094801

GI number: 222094801

Start: 1124742

End: 1125677

Strand: Direct

Name: hemH [H]

Synonym: BCQ_1139

Alternate gene names: 222094801

Gene position: 1124742-1125677 (Clockwise)

Preceding gene: 222094800

Following gene: 222094802

Centisome position: 21.57

GC content: 38.46

Gene sequence:

>936_bases
ATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATACGGAACGCCATATAAAGAAGAAGATATTGAACGTTACTATACACA
TATTCGCAGAGGAAGAAAGCCAAGTCCTGAAATGCTAGAAGATTTAACAGAGCGTTACCGTGCAATTGGTGGTATTTCTC
CTTTAGCTACTATTACATTAGAGCAAGCTAAGAAGTTAGAGAAGCGTTTAAATGAAGTACAAGATGAAGTCGAGTACCAT
ATGTATCTTGGCTTAAAACATATTGAACCGTTCATTGAAGATGCGGTGAAAGATATGCATAACGACGGTATACAAGATGC
AATCGCACTTGTTCTTGCGCCGCACTATTCTACGTTTAGCGTAAAATCATACGTTGGACGAGCACAAGAAGAAGCTGAGA
AACTTGGAAACTTAACAATTCATGGCATCGATAGCTGGTATAAAGAACCGAAATTTATCCAGTATTGGGTTGATGCAGTG
AAAGGTATATATAACGGTATGTCAGACGCAGAACGTGAAAAAGCAGTATTAATCGTATCAGCTCATAGCTTACCAGAAAA
AATTATCGCAATGGGCGATCCCTATCCAGATCAATTAAATGAAACAGCGGACTATATTGCAAGAGGCGCTGAAGTAGCAA
ACTATGCAGTAGGTTGGCAAAGTGCAGGAAACACACCAGATCCTTGGATTGGTCCAGATGTACAAGATTTAACGAGAGAA
CTAAATGAAAAGCACGGTTATACTTCATTCGTATATGCACCAGTTGGATTTGTTGCGGAACATTTAGAAGTTTTATATGA
CAACGACTTTGAGTGTAAAGTGGTAACGGATGAAATTGGCGCGAAATATTATCGTCCAGAAATGCCAAACGCATCGGATG
CATTTATTGACTGCTTAACAGATGTTGTAGTAAAGAAAAAAGAATCTGTACTGTAA

Upstream 100 bases:

>100_bases
GTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCATGAATACTCTAAAGGGCAGTTAGCG
AAGTAAAGGAGAATTGTTGT

Downstream 100 bases:

>100_bases
GAAGAAAGGGGGAGCCTGCTTGAGGAAAAAAGTTGTGATCATCGGCGGAGGCATCACTGGATTAACAGCAATGTATAACT
TACAAAAAAATATTCATGAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLTDVVVKKKESVL

Sequences:

>Translated_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLTDVVVKKKESVL
>Mature_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLTDVVVKKKESVL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=269, Percent_Identity=30.4832713754647, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=30.4832713754647, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324750, Length=282, Percent_Identity=26.9503546099291, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17864156, Length=328, Percent_Identity=25.3048780487805, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=31.1764705882353, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24651774, Length=253, Percent_Identity=22.5296442687747, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35288; Mature: 35288

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
VKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVS
HHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLT
HHHHCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHCCCCCCCCHHHHHHHHH
DVVVKKKESVL
HHHHHHHHCCC
>Mature Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
VKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVS
HHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLT
HHHHCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHCCCCCCCCHHHHHHHHH
DVVVKKKESVL
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]