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The map label for this gene is hemE

Identifier: 222094800

GI number: 222094800

Start: 1123756

End: 1124727

Strand: Direct

Name: hemE

Synonym: BCQ_1138

Alternate gene names: 222094800

Gene position: 1123756-1124727 (Clockwise)

Preceding gene: 222094799

Following gene: 222094801

Centisome position: 21.55

GC content: 39.3

Gene sequence:

>972_bases
ATGCGTCAAGCAGGTCGTTCGCAGCCGGAATATAGAAAGATAAAAGAAAAGTATTCTTTATTTGAAATTACACATAATCC
AGAGTTATGTGCTTACGTTACAAAACTGCCAGTTGATCAGTATAACGTAGACGCAGCAATTCTTTATAAAGATATTATGT
CACCACTACCTGCAATTGGTGTGGATGTAGAAATTAAATCAGGTATTGGCCCAGTTATTGATAATCCAATCCGTTCTTTA
CAAGACGTAGAAAAACTAGGGGAAATCAATCCAGAAGATGACGTACCGTACATATTAGATACAATTCGTTTATTAACGAC
TGAAATGCTAGACGTACCGTTAATCGGTTTTTCAGGAGCTCCATTTACGTTAGCGAGCTATATGATTGAAGGCGGTCCAT
CTCGTAACTACCATAATACGAAAGCGTTTATGTATGCAGAGCCGAAAGCTTGGTTCGCTTTAATGGATAAGCTAGCAGAT
ATGGTTATTACATATTTAAAAGCGCAAATTAACGCAGGAGCAAAAGCAGTTCAAATTTTCGATTCTTGGGTTGGAACAGT
AAACGTAGCAGATTATCGCGTATTTATTAAACCGGCAATGGAGCGTATTTTTGCAGAAGTTCGCACGATGGGTGTACCGA
TGATTATGCACGGCGTAGGAGCTGCACACTTAGTAAATGAATGGCACGACTTACCGCTTGATGTAGTCGGTTTAGACTGG
CGTTTACCAATTGAAGAAGCACGTGCACGCGGCGTTCACAAGGCGGTACAAGGTAATATGGATCCTTCGTTCTTACTTGC
ACCATGGTCTGTTATTGAAGAACATGTAAAAGGTATTTTAGATCAAGGGATGAAACAGCCGGGTTATATCTTTAACTTAG
GTCATGGTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCATGAATACTCTAAAGGGCAG
TTAGCGAAGTAA

Upstream 100 bases:

>100_bases
TGTGGTAAGGAAGGGAGCTAGGGTCTTGGTAAGAACTATAAATGAGACATTTTTAAAAGCATGTAGGGGGGAACGTACTG
ATTATGTACCAGCGTGGTAT

Downstream 100 bases:

>100_bases
AGGAGAATTGTTGTATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATACGGAACGCCATATAAAGAAGAAGATATTGAA
CGTTACTATACACATATTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSL
QDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALMDKLAD
MVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQ
LAK

Sequences:

>Translated_323_residues
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSL
QDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALMDKLAD
MVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQ
LAK
>Mature_323_residues
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSL
QDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALMDKLAD
MVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQ
LAK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=330, Percent_Identity=34.8484848484849, Blast_Score=192, Evalue=5e-49,
Organism=Escherichia coli, GI2367337, Length=325, Percent_Identity=40.9230769230769, Blast_Score=233, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6320252, Length=331, Percent_Identity=32.3262839879154, Blast_Score=172, Evalue=7e-44,
Organism=Drosophila melanogaster, GI221330099, Length=324, Percent_Identity=32.4074074074074, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19921920, Length=324, Percent_Identity=32.4074074074074, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_BACAH (A0RAS3)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_893823.1
- ProteinModelPortal:   A0RAS3
- SMR:   A0RAS3
- STRING:   A0RAS3
- EnsemblBacteria:   EBBACT00000070144
- GeneID:   4545660
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_0950
- eggNOG:   COG0407
- GeneTree:   EBGT00050000000611
- HOGENOM:   HBG628392
- ProtClustDB:   PRK00115
- BioCyc:   BTHU412694:BALH_0950-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 36210; Mature: 36210

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 46-46 BINDING 76-76 BINDING 152-152 BINDING 207-207 BINDING 320-320

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIG
CCCCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
VDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGA
CCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCC
PFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIF
CHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
HHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCEEEEECCC
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPE
CCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
VNPDTLKRLTTFIHEYSKGQLAK
CCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIG
CCCCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
VDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGA
CCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCC
PFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIF
CHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
HHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCEEEEECCC
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPE
CCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
VNPDTLKRLTTFIHEYSKGQLAK
CCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA