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The map label for this gene is comA [H]

Identifier: 222094610

GI number: 222094610

Start: 930068

End: 930727

Strand: Direct

Name: comA [H]

Synonym: BCQ_0948

Alternate gene names: 222094610

Gene position: 930068-930727 (Clockwise)

Preceding gene: 222094609

Following gene: 222094611

Centisome position: 17.84

GC content: 31.36

Gene sequence:

>660_bases
ATGATTTCGGTACTTGTAGTAGATGATCATGTCGCAGTAGGGTTAGGGACGAAGGCGTTAATTGAAAAATATGATGATAT
GCACGTAGAGGTAGTACATGATAGTACAGAAGTAGAGCAATTGCTTAAGGATAAAAAGTATGATGTATACTTAATTGATT
TACAAATGCCTAATGTGAATGGCTTAGATTTATCTAAGAAAATTATAAAGTTACATCCAGAGGCATCGATTCTTATTTTT
ACAGGGTTTGATATATTTTCTCATTATAATTTACTTATAGAAAATGGTGTTTTAGGCGTATTAAGTAAAACCTCATCAGA
AGAACAGGTAATTAATTCGATTCGTCATGCGGTGAAAAAAGAGGTAGTTTTATCTTATCAGCTTATTCGACAGTTAAGAA
TAAAAGAAGCGATTTCGAATATAAAGAATAAAGATGGAGAAATTACGAATCAAATTTCATTAAATGAAGATGAAAAACAA
ATCTTAATAGAAGTGAGTAAAGGAAAGACAAATAAAGAGCTTGCTGAAATTTTAAATTTAAGTCAACGTTCTGTAGAGTA
TAAGCTAACGGATATATTCCATAAATTAAAAGTTTCTTCTCGAATGGAAGCTGTGCAGAAGGCGAAAGAATTGTGGTTGA
TTCCGTCGCTTGATTTGTAA

Upstream 100 bases:

>100_bases
AGAAATGACTGTTGAATCAAAACCTAATCGTGGGTTACAAATAATTATTAAATTTTAGATGAATCATCAGATGATACGAT
AATATTGAAAGGGTGATAAT

Downstream 100 bases:

>100_bases
TTTACTAAAGTAATAATGATAAACAAATAGGTTTTTCTTCACGAAAGTGAAGAGAAACCTATTTGTTTATAAAGAGAAGT
ATCGAGATTGCGTTTTAGCG

Product: response regulator

Products: NA

Alternate protein names: Competence protein A [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MISVLVVDDHVAVGLGTKALIEKYDDMHVEVVHDSTEVEQLLKDKKYDVYLIDLQMPNVNGLDLSKKIIKLHPEASILIF
TGFDIFSHYNLLIENGVLGVLSKTSSEEQVINSIRHAVKKEVVLSYQLIRQLRIKEAISNIKNKDGEITNQISLNEDEKQ
ILIEVSKGKTNKELAEILNLSQRSVEYKLTDIFHKLKVSSRMEAVQKAKELWLIPSLDL

Sequences:

>Translated_219_residues
MISVLVVDDHVAVGLGTKALIEKYDDMHVEVVHDSTEVEQLLKDKKYDVYLIDLQMPNVNGLDLSKKIIKLHPEASILIF
TGFDIFSHYNLLIENGVLGVLSKTSSEEQVINSIRHAVKKEVVLSYQLIRQLRIKEAISNIKNKDGEITNQISLNEDEKQ
ILIEVSKGKTNKELAEILNLSQRSVEYKLTDIFHKLKVSSRMEAVQKAKELWLIPSLDL
>Mature_219_residues
MISVLVVDDHVAVGLGTKALIEKYDDMHVEVVHDSTEVEQLLKDKKYDVYLIDLQMPNVNGLDLSKKIIKLHPEASILIF
TGFDIFSHYNLLIENGVLGVLSKTSSEEQVINSIRHAVKKEVVLSYQLIRQLRIKEAISNIKNKDGEITNQISLNEDEKQ
ILIEVSKGKTNKELAEILNLSQRSVEYKLTDIFHKLKVSSRMEAVQKAKELWLIPSLDL

Specific function: Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, d

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=206, Percent_Identity=29.126213592233, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=32.0388349514563, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24903; Mature: 24903

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVLVVDDHVAVGLGTKALIEKYDDMHVEVVHDSTEVEQLLKDKKYDVYLIDLQMPNVN
CEEEEEECCCEEECCCHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCEEEEEEEECCCCC
GLDLSKKIIKLHPEASILIFTGFDIFSHYNLLIENGVLGVLSKTSSEEQVINSIRHAVKK
CCCHHHHHHEECCCCEEEEEECHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHH
EVVLSYQLIRQLRIKEAISNIKNKDGEITNQISLNEDEKQILIEVSKGKTNKELAEILNL
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHHHHCC
SQRSVEYKLTDIFHKLKVSSRMEAVQKAKELWLIPSLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MISVLVVDDHVAVGLGTKALIEKYDDMHVEVVHDSTEVEQLLKDKKYDVYLIDLQMPNVN
CEEEEEECCCEEECCCHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCEEEEEEEECCCCC
GLDLSKKIIKLHPEASILIFTGFDIFSHYNLLIENGVLGVLSKTSSEEQVINSIRHAVKK
CCCHHHHHHEECCCCEEEEEECHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHH
EVVLSYQLIRQLRIKEAISNIKNKDGEITNQISLNEDEKQILIEVSKGKTNKELAEILNL
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHHHHCC
SQRSVEYKLTDIFHKLKVSSRMEAVQKAKELWLIPSLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2507523; 9274030; 9384377 [H]