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The map label for this gene is comP [H]

Identifier: 222094609

GI number: 222094609

Start: 927734

End: 930025

Strand: Direct

Name: comP [H]

Synonym: BCQ_0947

Alternate gene names: 222094609

Gene position: 927734-930025 (Clockwise)

Preceding gene: 222094608

Following gene: 222094610

Centisome position: 17.79

GC content: 27.05

Gene sequence:

>2292_bases
ATGATAAAGAAAATGTGGAAATTTAAGGTTCAGTTTTTTATTTTATTACTAACGATTGTAGTTAGTTGGTACTGTGCTAG
CTTAATAAAAAATTATCCTGAAACTGGAATATCGGTAAAATATAATTCTGACCAGTATGTTATATGTGATCTCTCGAAAT
ATAGCTGGGCAGGGAAACGAGATTTTCAAATTGGAGACATTATAGAACAGATTGATGGTGAACCGCCATCTAAACATTTT
ACAGTTTCATCGTACCATTCAATTGAACAGGTGAAAAAAATAACGTTAAATAGGAATGGAGAAATAAAAGAGTTTGAGAT
AGAGTACCCGCCTTATAGTAAACAAGTTTTCTATCATCTTATTATTCCTATTGGTTTTTATATAGTATGTCTTTTAATGG
TATTATACTTATTAATATTTGTTCCGGAAATAAATCGTAGTACAAATGATTTATTATATTTTTTAATTTCACTTGGAGTT
AGTTTCATTAGTATTATAGCTGCTCAAAGAAAAGATACTTTATCCTTTATTGTGGCGTCACTTTCACTAGTATGTGTATT
TACTTTCTTTATAAGATTTATGAAAATGTACTTCTCTAATAATCAAATAAAGTTTTTAACACCAAAACAGTTAAAAATTT
TAAATTTCATATCAATATTTCTCGTTATATTAAGCATTCTTATACACATAAAATATAATGAATGGGCTAATTTATTTACA
ATTACTTTGAGTGCGCTACTATTTTTGTTTACAGTGTATCTTTTAGTAAGATTTTATTTTAAAAGTGGAAATAGCAGTTA
CTTTAAATATTTAAAAATTATTATTATTAGTTTTTTAGTGTCAGCAATTCCATTTATATGTTTATATTTAATTCCGAATT
TGTTTTATGGAGAAGAGTTTATAAGTAGCGAAACGACAGGCATATTTTTCTTATTTATTCCGATTTGTATTTTTTATTTA
GTAATCTCAGGGAAGATGTTTAATTTTAAATTTATTATTCAGCGACTTCCGTATTATATAGTTTTATCAGTAGGCGTTAA
CATGTTCTGTGCAGTATTAGGTATGGTCATCTTTGAAGACAGCGATGACCATTTATTAAAATGGGTTAAATTTAGAATAA
TTTCTATTATAATCTGTATTTGTTTTTTATACATTAAAGATTATATAGATTTAAAGCTAAGAAAAAGTTTGTATCATCAT
CAAAAAAATTATCAATTTAGTTTGCATCGTTTCTTACACCAAGCGAAAAATGAATATAAATTGCCCAATCTTATTTATAG
TATAAGAAGAGAAATATCAGATATATTGAAAATTGAAGAAACGTGTTGTGTGGAAATAAATAAGAGAGAACATTCTATTC
ATGTTCTCGAGAGTGAATATATTCCAAGAAGAACAATAGAAGCATTATTTAATCATCAGTTGGACACGTATCAAGTAGGT
TCCATCATACAGCTGGATAATCATTTTGGGTGTGTTCTTTCTATTTCAGGAGAAAAAATGATTATTTTAGTATGTAATCA
TAGTGAAAAAGAAAATTTAAATATAGATGAAATGGTTTGGATAGAAACATTATGTAATTATACAGATTTACTATTAGAAT
GCTCTAATCAAATTGAAGATTTATTAAAACAATTACAAGAAATAAATGATTTTGAGCAACCACCAATGTGGTTGGCAAGG
CTTATGTTTAAACTATCTGAAAAAGAAAGAACGAATCTTGCAAGTGATATACATGATGGAGTTTTACAAGATCAAATACG
TTTGTCTCGAAAATTTGAGAGTTATAAAGCTCGTGTTCAAGATGAAGAAACGAAAAAAATATTGAATGAAATTGAAGATG
AACTATTAGATCATATTTATACAATTCGGGAAACATGTAATAATTTGAGACCACCATTTCTATATGAGTTAGGTTTAAAA
CAAGCACTCATAAATTTATTTAAACAAATTAATTTAAAAGCGACATTTTTCTTTTATTATGATATTCCTGAACGAATTGT
TGCACCAAGTGTTGAACATGAACAAGCAATTTATCGAATTATGCAAGAGTTATTAAATAACGCTATGAAACATTCAAAAG
CAACAAACGTAACAGTAAGATTATTTGAAAAAGACGAGCATTTATATTTAACTTATATAGATAATGGAGTTGGGATTGAG
TTAGATGAAGTAAACTATTCTTACAACACATTAGGCTTGTCTGGGATTGTTACTAGAATCCAAAGTTTGAATGGAGAAAT
GACTGTTGAATCAAAACCTAATCGTGGGTTACAAATAATTATTAAATTTTAG

Upstream 100 bases:

>100_bases
CTACTTCTTTTATGAAGTGGGGTTATTTTTAATTTTTCGTTAAGGGTGTAAAATACTATTTTTGTTTGGGGATTGTGTGT
ATTCGAAAAGGAGTTATGCA

Downstream 100 bases:

>100_bases
ATGAATCATCAGATGATACGATAATATTGAAAGGGTGATAATATGATTTCGGTACTTGTAGTAGATGATCATGTCGCAGT
AGGGTTAGGGACGAAGGCGT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MIKKMWKFKVQFFILLLTIVVSWYCASLIKNYPETGISVKYNSDQYVICDLSKYSWAGKRDFQIGDIIEQIDGEPPSKHF
TVSSYHSIEQVKKITLNRNGEIKEFEIEYPPYSKQVFYHLIIPIGFYIVCLLMVLYLLIFVPEINRSTNDLLYFLISLGV
SFISIIAAQRKDTLSFIVASLSLVCVFTFFIRFMKMYFSNNQIKFLTPKQLKILNFISIFLVILSILIHIKYNEWANLFT
ITLSALLFLFTVYLLVRFYFKSGNSSYFKYLKIIIISFLVSAIPFICLYLIPNLFYGEEFISSETTGIFFLFIPICIFYL
VISGKMFNFKFIIQRLPYYIVLSVGVNMFCAVLGMVIFEDSDDHLLKWVKFRIISIIICICFLYIKDYIDLKLRKSLYHH
QKNYQFSLHRFLHQAKNEYKLPNLIYSIRREISDILKIEETCCVEINKREHSIHVLESEYIPRRTIEALFNHQLDTYQVG
SIIQLDNHFGCVLSISGEKMIILVCNHSEKENLNIDEMVWIETLCNYTDLLLECSNQIEDLLKQLQEINDFEQPPMWLAR
LMFKLSEKERTNLASDIHDGVLQDQIRLSRKFESYKARVQDEETKKILNEIEDELLDHIYTIRETCNNLRPPFLYELGLK
QALINLFKQINLKATFFFYYDIPERIVAPSVEHEQAIYRIMQELLNNAMKHSKATNVTVRLFEKDEHLYLTYIDNGVGIE
LDEVNYSYNTLGLSGIVTRIQSLNGEMTVESKPNRGLQIIIKF

Sequences:

>Translated_763_residues
MIKKMWKFKVQFFILLLTIVVSWYCASLIKNYPETGISVKYNSDQYVICDLSKYSWAGKRDFQIGDIIEQIDGEPPSKHF
TVSSYHSIEQVKKITLNRNGEIKEFEIEYPPYSKQVFYHLIIPIGFYIVCLLMVLYLLIFVPEINRSTNDLLYFLISLGV
SFISIIAAQRKDTLSFIVASLSLVCVFTFFIRFMKMYFSNNQIKFLTPKQLKILNFISIFLVILSILIHIKYNEWANLFT
ITLSALLFLFTVYLLVRFYFKSGNSSYFKYLKIIIISFLVSAIPFICLYLIPNLFYGEEFISSETTGIFFLFIPICIFYL
VISGKMFNFKFIIQRLPYYIVLSVGVNMFCAVLGMVIFEDSDDHLLKWVKFRIISIIICICFLYIKDYIDLKLRKSLYHH
QKNYQFSLHRFLHQAKNEYKLPNLIYSIRREISDILKIEETCCVEINKREHSIHVLESEYIPRRTIEALFNHQLDTYQVG
SIIQLDNHFGCVLSISGEKMIILVCNHSEKENLNIDEMVWIETLCNYTDLLLECSNQIEDLLKQLQEINDFEQPPMWLAR
LMFKLSEKERTNLASDIHDGVLQDQIRLSRKFESYKARVQDEETKKILNEIEDELLDHIYTIRETCNNLRPPFLYELGLK
QALINLFKQINLKATFFFYYDIPERIVAPSVEHEQAIYRIMQELLNNAMKHSKATNVTVRLFEKDEHLYLTYIDNGVGIE
LDEVNYSYNTLGLSGIVTRIQSLNGEMTVESKPNRGLQIIIKF
>Mature_763_residues
MIKKMWKFKVQFFILLLTIVVSWYCASLIKNYPETGISVKYNSDQYVICDLSKYSWAGKRDFQIGDIIEQIDGEPPSKHF
TVSSYHSIEQVKKITLNRNGEIKEFEIEYPPYSKQVFYHLIIPIGFYIVCLLMVLYLLIFVPEINRSTNDLLYFLISLGV
SFISIIAAQRKDTLSFIVASLSLVCVFTFFIRFMKMYFSNNQIKFLTPKQLKILNFISIFLVILSILIHIKYNEWANLFT
ITLSALLFLFTVYLLVRFYFKSGNSSYFKYLKIIIISFLVSAIPFICLYLIPNLFYGEEFISSETTGIFFLFIPICIFYL
VISGKMFNFKFIIQRLPYYIVLSVGVNMFCAVLGMVIFEDSDDHLLKWVKFRIISIIICICFLYIKDYIDLKLRKSLYHH
QKNYQFSLHRFLHQAKNEYKLPNLIYSIRREISDILKIEETCCVEINKREHSIHVLESEYIPRRTIEALFNHQLDTYQVG
SIIQLDNHFGCVLSISGEKMIILVCNHSEKENLNIDEMVWIETLCNYTDLLLECSNQIEDLLKQLQEINDFEQPPMWLAR
LMFKLSEKERTNLASDIHDGVLQDQIRLSRKFESYKARVQDEETKKILNEIEDELLDHIYTIRETCNNLRPPFLYELGLK
QALINLFKQINLKATFFFYYDIPERIVAPSVEHEQAIYRIMQELLNNAMKHSKATNVTVRLFEKDEHLYLTYIDNGVGIE
LDEVNYSYNTLGLSGIVTRIQSLNGEMTVESKPNRGLQIIIKF

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=202, Percent_Identity=29.2079207920792, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 89823; Mature: 89823

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKMWKFKVQFFILLLTIVVSWYCASLIKNYPETGISVKYNSDQYVICDLSKYSWAGKR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECHHCCCCCCC
DFQIGDIIEQIDGEPPSKHFTVSSYHSIEQVKKITLNRNGEIKEFEIEYPPYSKQVFYHL
CCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHH
IIPIGFYIVCLLMVLYLLIFVPEINRSTNDLLYFLISLGVSFISIIAAQRKDTLSFIVAS
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLVCVFTFFIRFMKMYFSNNQIKFLTPKQLKILNFISIFLVILSILIHIKYNEWANLFT
HHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ITLSALLFLFTVYLLVRFYFKSGNSSYFKYLKIIIISFLVSAIPFICLYLIPNLFYGEEF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ISSETTGIFFLFIPICIFYLVISGKMFNFKFIIQRLPYYIVLSVGVNMFCAVLGMVIFED
HCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
SDDHLLKWVKFRIISIIICICFLYIKDYIDLKLRKSLYHHQKNYQFSLHRFLHQAKNEYK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
LPNLIYSIRREISDILKIEETCCVEINKREHSIHVLESEYIPRRTIEALFNHQLDTYQVG
CHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCHHHHHHHHCCCCCCEECC
SIIQLDNHFGCVLSISGEKMIILVCNHSEKENLNIDEMVWIETLCNYTDLLLECSNQIED
CEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKQLQEINDFEQPPMWLARLMFKLSEKERTNLASDIHDGVLQDQIRLSRKFESYKARVQ
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEETKKILNEIEDELLDHIYTIRETCNNLRPPFLYELGLKQALINLFKQINLKATFFFYY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DIPERIVAPSVEHEQAIYRIMQELLNNAMKHSKATNVTVRLFEKDEHLYLTYIDNGVGIE
ECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCEE
LDEVNYSYNTLGLSGIVTRIQSLNGEMTVESKPNRGLQIIIKF
EECCCCCCHHCCHHHHHHHHHHCCCCEEECCCCCCCEEEEEEC
>Mature Secondary Structure
MIKKMWKFKVQFFILLLTIVVSWYCASLIKNYPETGISVKYNSDQYVICDLSKYSWAGKR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECHHCCCCCCC
DFQIGDIIEQIDGEPPSKHFTVSSYHSIEQVKKITLNRNGEIKEFEIEYPPYSKQVFYHL
CCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHH
IIPIGFYIVCLLMVLYLLIFVPEINRSTNDLLYFLISLGVSFISIIAAQRKDTLSFIVAS
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLVCVFTFFIRFMKMYFSNNQIKFLTPKQLKILNFISIFLVILSILIHIKYNEWANLFT
HHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ITLSALLFLFTVYLLVRFYFKSGNSSYFKYLKIIIISFLVSAIPFICLYLIPNLFYGEEF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ISSETTGIFFLFIPICIFYLVISGKMFNFKFIIQRLPYYIVLSVGVNMFCAVLGMVIFED
HCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
SDDHLLKWVKFRIISIIICICFLYIKDYIDLKLRKSLYHHQKNYQFSLHRFLHQAKNEYK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
LPNLIYSIRREISDILKIEETCCVEINKREHSIHVLESEYIPRRTIEALFNHQLDTYQVG
CHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCHHHHHHHHCCCCCCEECC
SIIQLDNHFGCVLSISGEKMIILVCNHSEKENLNIDEMVWIETLCNYTDLLLECSNQIED
CEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKQLQEINDFEQPPMWLARLMFKLSEKERTNLASDIHDGVLQDQIRLSRKFESYKARVQ
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEETKKILNEIEDELLDHIYTIRETCNNLRPPFLYELGLKQALINLFKQINLKATFFFYY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DIPERIVAPSVEHEQAIYRIMQELLNNAMKHSKATNVTVRLFEKDEHLYLTYIDNGVGIE
ECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCEE
LDEVNYSYNTLGLSGIVTRIQSLNGEMTVESKPNRGLQIIIKF
EECCCCCCHHCCHHHHHHHHHHCCCCEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859 [H]