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The map label for this gene is norA [H]

Identifier: 222094537

GI number: 222094537

Start: 858634

End: 860154

Strand: Reverse

Name: norA [H]

Synonym: BCQ_0875

Alternate gene names: 222094537

Gene position: 860154-858634 (Counterclockwise)

Preceding gene: 222094546

Following gene: 222094536

Centisome position: 16.5

GC content: 36.75

Gene sequence:

>1521_bases
ATGTACACGCCTCTTTCTTCATCATATTGTAAACCTTTTCAAATATATGTAGCGAAAAAGTATATATCCCCTTCTCATTC
ACTACTTTTTGAATCCGCTTTCTTTAAAGAAAAAACAATTTCTATCATTCATAACAACTACCAGTCTATACATCTATACT
TTACATCTTTTTTTCATAGTTGTGTAGTCTTTCCACAAATTTGTCAGTTTTTTACCTCGAAAATTGTTGTACGTTTTCAA
GGCACCTTCCTTGACTGTTTCATTGGCCAATACATATACTCGAAAGAAAAGAGAAATTTTTATATAGGGGATGAATATAT
GGGAGAAGCAATACTCGTAAAACGAGAACCGTTATGGACGAAAGAATTTGTTGCGCTAATTCTAGCAAACTTATGTATGT
TTTTAGGATTTCAAATGTTAATTCCGACTTTACCTGTTTATGTGAAAGAAATTGGAGGTACAAGTTCCAATATTGGATTT
GTTGTCGGTATGTTTACTGTTGCGGCACTTTTTGTTAGACCGCTAACTGGAAATGCCTTGCAAAAATTCAGCAAAAAAAT
CATTTTAATGATCGGTACTGCTATTTGTTTACTCGCTATGGGTAGTTATCTTTTCGCTTCAACTGTTTTCCTATTGCTTG
CCGTTCGAATTTTACACGGAGCTGGTTTTGGTATTACAACGACTACATATGGAACTGTCGTTTCAGATTTAATTCCGCAA
GCTCGCCGCGGTGAAGGCATGGGATATTTCGGTCTTTCTGGAACGATTGCAATGGCGCTCGGTCCACTTATCGGACTTTG
GCTTATGCAAACATATAACTTCACGATTCTTTTTTTATGTGCACTTTCCTGTACAATTGTTTCATTAATATTAACGAAAC
TACTTCAAATCAAAAAATCGCCGCAATCACCACAGCAAACATCTGGTACCTTCCTTGATGGATTTATTGAACGTAAAGCT
TTACTTCCTTCATTATTAATATTATGTATTACATTAATGTACGGGGGAATCGGAAGCTTTATTACGTTATTTGCTACGGA
AGTCGGCATTGCTGATATAAGCCTCTTCTTCTTATTTAATGCACTTGCAATCGCTGTTACTCGTCCATTTTCCGGAAAGT
TATATGATGCGAAAGGTCATTCCTTCGTAATTATTCCAGGAGTTATTATTACGTTTACAGGGATTATTTTATTGTCGTAT
ACAACTACCATTCCAAGCTTAATTATTGCAGCAGCATGCTACGGAAGTGGTTTCGGAGCGATTCAACCTGCACTACAAGC
GTGGATGATTGACCGAGTAGCACCGCACCGACGAGGAGTCGCAACAGCTACATTCTTCTCAGCATTTGACCTTGGAATTG
GTGCTGGCGCGATTATTTTTGGATTCATTGCACATTTTACAAACTACGCAACTGTATATCGTTATTCCTCTCTATTACTT
ATTGCTTTCCTATTCATTTACATCACAAGTGTAAGAAGACAAAAGCATGGAAATAAAAACACAGAAAAAGCTGCTGGATA
A

Upstream 100 bases:

>100_bases
ATACACGAGTAAATCCGTATTTACTTGCTAATGTTAAATACTCTTTATCTTTCTCTACTGTTGAATGTTCTGGATAAATA
GAAATACCTAATCGTCTCAT

Downstream 100 bases:

>100_bases
TTCCAGTGGCTTTTTTATCTTATTTTTGATGTTATAAAATTACATGCATTTTCCTACATATTTTTTAAATTTTCATCAAA
AAATATACGATGAACTCGCA

Product: quinolone resistence nora protein, major facilitator family transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MYTPLSSSYCKPFQIYVAKKYISPSHSLLFESAFFKEKTISIIHNNYQSIHLYFTSFFHSCVVFPQICQFFTSKIVVRFQ
GTFLDCFIGQYIYSKEKRNFYIGDEYMGEAILVKREPLWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGF
VVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQ
ARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKSPQSPQQTSGTFLDGFIERKA
LLPSLLILCITLMYGGIGSFITLFATEVGIADISLFFLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFTGIILLSY
TTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLL
IAFLFIYITSVRRQKHGNKNTEKAAG

Sequences:

>Translated_506_residues
MYTPLSSSYCKPFQIYVAKKYISPSHSLLFESAFFKEKTISIIHNNYQSIHLYFTSFFHSCVVFPQICQFFTSKIVVRFQ
GTFLDCFIGQYIYSKEKRNFYIGDEYMGEAILVKREPLWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGF
VVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQ
ARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKSPQSPQQTSGTFLDGFIERKA
LLPSLLILCITLMYGGIGSFITLFATEVGIADISLFFLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFTGIILLSY
TTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLL
IAFLFIYITSVRRQKHGNKNTEKAAG
>Mature_506_residues
MYTPLSSSYCKPFQIYVAKKYISPSHSLLFESAFFKEKTISIIHNNYQSIHLYFTSFFHSCVVFPQICQFFTSKIVVRFQ
GTFLDCFIGQYIYSKEKRNFYIGDEYMGEAILVKREPLWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGF
VVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQ
ARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKSPQSPQQTSGTFLDGFIERKA
LLPSLLILCITLMYGGIGSFITLFATEVGIADISLFFLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFTGIILLSY
TTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLL
IAFLFIYITSVRRQKHGNKNTEKAAG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55780; Mature: 55780

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00359 RIBOSOMAL_L11 ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTPLSSSYCKPFQIYVAKKYISPSHSLLFESAFFKEKTISIIHNNYQSIHLYFTSFFHS
CCCCCCCCCCCCHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
CVVFPQICQFFTSKIVVRFQGTFLDCFIGQYIYSKEKRNFYIGDEYMGEAILVKREPLWT
HHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCEEECHHHCCCEEEEECCCCCH
KEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
QKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCH
ARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKS
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQSPQQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADISLFFLFN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFTGIILLSYTTTIPSLIIAAACYGSGFGA
HHHHHHCCCCCCCEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IAFLFIYITSVRRQKHGNKNTEKAAG
HHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYTPLSSSYCKPFQIYVAKKYISPSHSLLFESAFFKEKTISIIHNNYQSIHLYFTSFFHS
CCCCCCCCCCCCHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
CVVFPQICQFFTSKIVVRFQGTFLDCFIGQYIYSKEKRNFYIGDEYMGEAILVKREPLWT
HHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCEEECHHHCCCEEEEECCCCCH
KEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
QKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCH
ARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKS
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQSPQQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADISLFFLFN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFTGIILLSYTTTIPSLIIAAACYGSGFGA
HHHHHHCCCCCCCEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IAFLFIYITSVRRQKHGNKNTEKAAG
HHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]