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The map label for this gene is trmA [C]

Identifier: 222094090

GI number: 222094090

Start: 362780

End: 364156

Strand: Direct

Name: trmA [C]

Synonym: BCQ_0383

Alternate gene names: 222094090

Gene position: 362780-364156 (Clockwise)

Preceding gene: 222094086

Following gene: 222094091

Centisome position: 6.96

GC content: 39.29

Gene sequence:

>1377_bases
ATGAGTACAAAAATGACGCCACCAGTTGAAAAAAACGAGTTTATAGATGTAGTATTTGAAGATTTAACACATGATGGTGC
CGGTGTTGCGAAAGTAAAAGGCTATCCTATTTTCGTTAAAAACGGATTACCAGGTGAAGAAGCACAAATTAAAATTATTA
AAGTAAAGAAAAACTTCGCATTCGGTCGTTTAATGAAGCTTCATACAAAGAGCCCATATCGTAAAGATGCAGAATGCCCA
GTGTACAATCAGTGCGGTGGTTGTCAGCTTCAGCATTTAACATATGAAGGGCAATTACAAGCGAAAGAAAAACAAGTACG
CGACGTTATGCAGCGCATCGGCGGATTAAGTGATGTTCCTGTTCATCCTGTACTTGGCATGAAGAATCCGTGGGTATACC
GTAACAAAGCACAAGTACCAATTGGAGAACGTGAAGGTGGACTTGTAGCTGGATTCTATCGTCAAGGAACGCATGACATC
ATTAATATGGAATCGTGTTTAATTCAAGCAGAAGAAAACGATACATTAATTCAAGAAGTAAAACGTATTTGTGAAAAACA
CGGGATTTCAGCGTACAATGAAGAGCGTAACAAAGGAACACTTCGCCACGTAATGGCTCGTTACGGACAAGTAACAGGGG
AAATTATGCTTGTCTTCATTACTCGTACAGCAGAATTACCAAACAAGAAAGCAATCATTGAAGAAATTGCTGCGAAATTC
CCTGAAGTAAAATCGATTGTTCAAAACGTAAACACGAAACGTACAAACGTAATCTTCGGAGACAAAACGACAGTACTGTA
CGGATCAGAATATATTTATGACTTTATTGGCGATATTAAATTTGCGATTTCAGCACGTTCATTCTATCAAGTAAACCCAG
AACAAACGAAAGTGCTGTACGATAAAACGTTAGAATACGCAAAATTAGATGGTAACGAAACAGTAATTGATGCCTATTGC
GGAATTGGATCAATCTCTTTATTCCTAGCGCAAAAAGCGAAAAAAGTGTATGGCGTTGAAATCGTCCCAGAAGCGATTGA
AGACGCAAAGCGTAACGCAGCACTAAACAACATGACAAACGCTGAATTTGGTGTAGGAGAAGCAGAAGTAGTTATTCCAA
AATGGTATAAAGAAGGCGTAATCGCTGACACAATGGTCGTAGATCCACCGCGTAAAGGTTGTGATGAGGCACTATTAAAC
ACAATCATCGACATGAAACCAAAACGCGTTGTATACGTATCATGTAACCCAGCAACATTAGCACGTGACTTAAAAGTACT
AGAAGAAGGCGGATATAAAACGCAGGAAGTACAACCTGTTGATATGTTCCCGCATACGACTCATGTAGAGTGTGTAGCTT
GGCTTAAGTTGGTATAA

Upstream 100 bases:

>100_bases
ACGGAGAACTATCGTCAATAGCTTTTTTTCTTCCAATAGAAATAGACCATATAAGTATGATAAAATGTAACGCAGTGTTA
TGAAAAAGAGAGGTCGGAAA

Downstream 100 bases:

>100_bases
TAGGAAAGCAGTTGATATAGGAAAATCTATACCATCTGCTTTTTGGTTTATTGAGAGTTTGAAATTGTATTCATAGTGAG
AGGATTTGAATTTGAAATGA

Product: RNA methyltransferase protein, trma family (tRNA (uracil-5-)-methyltransferase)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSTKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIIKVKKNFAFGRLMKLHTKSPYRKDAECP
VYNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLSDVPVHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDI
INMESCLIQAEENDTLIQEVKRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKF
PEVKSIVQNVNTKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLYDKTLEYAKLDGNETVIDAYC
GIGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTNAEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLN
TIIDMKPKRVVYVSCNPATLARDLKVLEEGGYKTQEVQPVDMFPHTTHVECVAWLKLV

Sequences:

>Translated_458_residues
MSTKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIIKVKKNFAFGRLMKLHTKSPYRKDAECP
VYNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLSDVPVHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDI
INMESCLIQAEENDTLIQEVKRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKF
PEVKSIVQNVNTKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLYDKTLEYAKLDGNETVIDAYC
GIGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTNAEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLN
TIIDMKPKRVVYVSCNPATLARDLKVLEEGGYKTQEVQPVDMFPHTTHVECVAWLKLV
>Mature_457_residues
STKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIIKVKKNFAFGRLMKLHTKSPYRKDAECPV
YNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLSDVPVHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDII
NMESCLIQAEENDTLIQEVKRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKFP
EVKSIVQNVNTKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLYDKTLEYAKLDGNETVIDAYCG
IGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTNAEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLNT
IIDMKPKRVVYVSCNPATLARDLKVLEEGGYKTQEVQPVDMFPHTTHVECVAWLKLV

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=346, Percent_Identity=28.0346820809249, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI51173878, Length=346, Percent_Identity=28.0346820809249, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI269784680, Length=415, Percent_Identity=24.8192771084337, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI269784676, Length=415, Percent_Identity=24.8192771084337, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI20149688, Length=415, Percent_Identity=24.8192771084337, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI269784678, Length=205, Percent_Identity=32.6829268292683, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1789148, Length=455, Percent_Identity=30.1098901098901, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787083, Length=386, Percent_Identity=26.6839378238342, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790403, Length=181, Percent_Identity=29.8342541436464, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71997438, Length=171, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322909, Length=441, Percent_Identity=25.8503401360544, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24666579, Length=410, Percent_Identity=29.7560975609756, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- InterPro:   IPR003402 [H]

Pfam domain/function: PF02475 Met_10; PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51359; Mature: 51228

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1 ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIIKVKKNFA
CCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCEEEEEEEECCCC
FGRLMKLHTKSPYRKDAECPVYNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLSDVP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCC
VHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDIINMESCLIQAEENDTLIQEV
CCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCHHEEHHHHEEEECCCCHHHHHH
KRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKF
HHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHC
PEVKSIVQNVNTKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLY
HHHHHHHHCCCCCCCEEEECCCEEEEECCHHHHHHHCCCEEEEEECEEEEECHHHHHHHH
DKTLEYAKLDGNETVIDAYCGIGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTN
HHCCHHEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHCCCCC
AEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLNTIIDMKPKRVVYVSCNPATL
CCCCCCCEEEEECCHHCCCCEECEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHH
ARDLKVLEEGGYKTQEVQPVDMFPHTTHVECVAWLKLV
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STKMTPPVEKNEFIDVVFEDLTHDGAGVAKVKGYPIFVKNGLPGEEAQIKIIKVKKNFA
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCEEEEEEEECCCC
FGRLMKLHTKSPYRKDAECPVYNQCGGCQLQHLTYEGQLQAKEKQVRDVMQRIGGLSDVP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCC
VHPVLGMKNPWVYRNKAQVPIGEREGGLVAGFYRQGTHDIINMESCLIQAEENDTLIQEV
CCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCHHEEHHHHEEEECCCCHHHHHH
KRICEKHGISAYNEERNKGTLRHVMARYGQVTGEIMLVFITRTAELPNKKAIIEEIAAKF
HHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHC
PEVKSIVQNVNTKRTNVIFGDKTTVLYGSEYIYDFIGDIKFAISARSFYQVNPEQTKVLY
HHHHHHHHCCCCCCCEEEECCCEEEEECCHHHHHHHCCCEEEEEECEEEEECHHHHHHHH
DKTLEYAKLDGNETVIDAYCGIGSISLFLAQKAKKVYGVEIVPEAIEDAKRNAALNNMTN
HHCCHHEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHCCCCC
AEFGVGEAEVVIPKWYKEGVIADTMVVDPPRKGCDEALLNTIIDMKPKRVVYVSCNPATL
CCCCCCCEEEEECCHHCCCCEECEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHH
ARDLKVLEEGGYKTQEVQPVDMFPHTTHVECVAWLKLV
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA