Click here to switch to the map view.

The map label for this gene is ubiE [H]

Identifier: 221636315

GI number: 221636315

Start: 891815

End: 892588

Strand: Reverse

Name: ubiE [H]

Synonym: trd_A0909

Alternate gene names: 221636315

Gene position: 892588-891815 (Counterclockwise)

Preceding gene: 221636316

Following gene: 221636313

Centisome position: 97.26

GC content: 67.05

Gene sequence:

>774_bases
ATGCCCCGCCGTGGTGCACTACAACCGCCAGCGGAAGTCCGGCGTATGTTCGACCGGATCGCCCCGCGCTACGACGTCAT
GAACCGGCTGATGACGTTCGGCCGCGACGTGACCTGGCGCCGAGCAGCTGCCCGTGCCGCCCTCACTCACCAGCCAGCAG
TCGTGCTCGATGTCGCGACGGGTACCGGGGACCTCGCCTTCGAGCTCGCTGCTCAGGGTGCAGCGCGCGTCGTCGCGCTC
GACTTCAGCCGGACGATGCTTCGGCACGCCGCGCGCAAGCGCTCCGCGTCTGGTCTCGATCGGGTCACGCTCCTCTGCGG
GGACGCGATGCGCCTCCCGTTCCGCGATGCCTCGATCGATGCCTGTACGATCGGCTTCGGATTGCGCAATTTTCCGGATT
ACGAGGCAGCGATCCACGAACTCGCCCGCGTCGTGCGCCCCGGCGGCGTACTTGTGATTCTGGAGACGACGCCCTTCCAA
GGACCGCTCGCTCCCCTGCTTCGATTCTATTTCGACTGCTTTGTCCCCTGGCTCGGTGGCCTGGTCAGTGGTGACCGGGC
AGCGTACAGCTATCTCCCCCGCTCGACAGCTGCCTTCCCTACAGCTAGCGAGCTTACGGCGCTCCTACGAGCGGCCGGTT
TCGCTTCCGTGCAGGCCCGGAAACTCATGGCCGGTACCGTCGCGCTCCATATCGCGGTGCGTGCCGAGGGTGGACAGCCC
GCGCGTGATGCGGTGCGAGCTGTACCTGGGTTGACGGAGGCCGCGCGCCGCTAA

Upstream 100 bases:

>100_bases
CTGCGTGCCCTCGAGGGGCATATCCTGGCTATCGGTGAACTGGTCGGCACCTACGGTCGCGAGCCGGTGCGTTAGTATTG
TCGATGGAAAGGGAGACGCG

Downstream 100 bases:

>100_bases
ACGACCCGGCGAGTCGGCGTGCGTTGCCAGCACAAACGGTCGGCGAACCTCATTCCTCCCTGACGGGTCGCACTGCCTCC
CTCAGGCTGACTGCAGTATC

Product: menaquinone biosynthesis methyltransferase UbiE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MPRRGALQPPAEVRRMFDRIAPRYDVMNRLMTFGRDVTWRRAAARAALTHQPAVVLDVATGTGDLAFELAAQGAARVVAL
DFSRTMLRHAARKRSASGLDRVTLLCGDAMRLPFRDASIDACTIGFGLRNFPDYEAAIHELARVVRPGGVLVILETTPFQ
GPLAPLLRFYFDCFVPWLGGLVSGDRAAYSYLPRSTAAFPTASELTALLRAAGFASVQARKLMAGTVALHIAVRAEGGQP
ARDAVRAVPGLTEAARR

Sequences:

>Translated_257_residues
MPRRGALQPPAEVRRMFDRIAPRYDVMNRLMTFGRDVTWRRAAARAALTHQPAVVLDVATGTGDLAFELAAQGAARVVAL
DFSRTMLRHAARKRSASGLDRVTLLCGDAMRLPFRDASIDACTIGFGLRNFPDYEAAIHELARVVRPGGVLVILETTPFQ
GPLAPLLRFYFDCFVPWLGGLVSGDRAAYSYLPRSTAAFPTASELTALLRAAGFASVQARKLMAGTVALHIAVRAEGGQP
ARDAVRAVPGLTEAARR
>Mature_256_residues
PRRGALQPPAEVRRMFDRIAPRYDVMNRLMTFGRDVTWRRAAARAALTHQPAVVLDVATGTGDLAFELAAQGAARVVALD
FSRTMLRHAARKRSASGLDRVTLLCGDAMRLPFRDASIDACTIGFGLRNFPDYEAAIHELARVVRPGGVLVILETTPFQG
PLAPLLRFYFDCFVPWLGGLVSGDRAAYSYLPRSTAAFPTASELTALLRAAGFASVQARKLMAGTVALHIAVRAEGGQPA
RDAVRAVPGLTEAARR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=260, Percent_Identity=31.5384615384615, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI48994983, Length=227, Percent_Identity=37.0044052863436, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17557039, Length=232, Percent_Identity=31.4655172413793, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323526, Length=240, Percent_Identity=27.5, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24641702, Length=244, Percent_Identity=30.7377049180328, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27816; Mature: 27684

Theoretical pI: Translated: 11.28; Mature: 11.28

Prosite motif: PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRRGALQPPAEVRRMFDRIAPRYDVMNRLMTFGRDVTWRRAAARAALTHQPAVVLDVAT
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEC
GTGDLAFELAAQGAARVVALDFSRTMLRHAARKRSASGLDRVTLLCGDAMRLPFRDASID
CCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHEEECCHHCCCCCCCCCC
ACTIGFGLRNFPDYEAAIHELARVVRPGGVLVILETTPFQGPLAPLLRFYFDCFVPWLGG
EEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
LVSGDRAAYSYLPRSTAAFPTASELTALLRAAGFASVQARKLMAGTVALHIAVRAEGGQP
HCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHEEEEEEEEECCCCC
ARDAVRAVPGLTEAARR
HHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
PRRGALQPPAEVRRMFDRIAPRYDVMNRLMTFGRDVTWRRAAARAALTHQPAVVLDVAT
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEC
GTGDLAFELAAQGAARVVALDFSRTMLRHAARKRSASGLDRVTLLCGDAMRLPFRDASID
CCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHEEECCHHCCCCCCCCCC
ACTIGFGLRNFPDYEAAIHELARVVRPGGVLVILETTPFQGPLAPLLRFYFDCFVPWLGG
EEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
LVSGDRAAYSYLPRSTAAFPTASELTALLRAAGFASVQARKLMAGTVALHIAVRAEGGQP
HCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHEEEEEEEEECCCCC
ARDAVRAVPGLTEAARR
HHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA