Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 221636087

GI number: 221636087

Start: 671738

End: 672586

Strand: Reverse

Name: cobB [H]

Synonym: trd_A0681

Alternate gene names: 221636087

Gene position: 672586-671738 (Counterclockwise)

Preceding gene: 221636089

Following gene: 221636086

Centisome position: 73.29

GC content: 69.49

Gene sequence:

>849_bases
GTGGGCTTGGTAGGATTGGGAACGGAGGGGGAAGCAGCGGTGGACGGCGGAGCGCTCAGTGCGGAGCAGCGGCGGCTGGT
CGAGGCGATCGCGGATGCGCTCTACCAGCGGGGGCCAGGTATGGCCTTCACTGGCGCGGGGATCTCCACCGAGTCCGGGA
TACCGGACTATCGCGGGCCGAACGGGCTGTGGTCGCGCGAGAATCCGACCCGCTACCGCGATTTTCTGAACGACCCTGAG
GTGCGGCGCCGTTACTGGGATCGACGACGCCAACGCTATCCGATCCTCGCCGGGGCGCGGCCCAATGTGGGACACGTGGC
GCTGGCGCGCCTGCAGGCTGCGGGGTATCTGGAGATCATCGTGACGCAGAACATCGATGGGCTGCACCAGAAGGCGGGCA
GTCCGCCGGAGCGGGTAGTCGAGCTGCACGGGACGGCGCATGCCATCCGCTGCCTGTCGTGCGAGCTGCTCTGGCCGGCC
GAGGAGTTCGACCCTGGTCCGCCTGGAACGATCCCGGATTGTCCCGTCTGCGGTGGCCTGGTGAAAGAAGCCACCGTTTC
CTTCGGCGAGCCGGTGCCGCGCCGGATTCTCGAGCATGCGCTGGCGCTCGCCGAAGCGACGCCGGTCATGCTGGTGATCG
GTACCTCGCTCAAGGTCGTGCCGGCGGCTCATGTGCCGCGCCGTGCAGCGCGAGCGGGGGCATTCGTCGCGATCGTCAAT
GACGAACCGACCCCGCTCGACCGGGAAGCGGCAGTCGTCCTCCGGGCTCGGGCCGGGGCCGCGCTCGCCTACCTCGCCGA
ACTCCTCGTCGGTGCGCCGGCCGACTCCGCTCGCGAACGCGCGAGCTGA

Upstream 100 bases:

>100_bases
TCGATACCGCGAGTCGGTTGTCGAGCAGGCGGGCCGCCCGGGAGCAGCGGTTGGGACACGCGAACGGGACGACGTGAAAC
GGGCAGCCCGTCAGGCTCTC

Downstream 100 bases:

>100_bases
GCCAGCGACCGAGCTCGGTGAACGAAACGGCAGATCCCGCACGCGACCGTTCGCGCTGGGATACCGGCGGACAGCCGCAC
CGCCCAGCGACCGAGCGTTC

Product: NAD-dependent deacetylase 1 (Regulatory protein SIR2homolog 1)

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MGLVGLGTEGEAAVDGGALSAEQRRLVEAIADALYQRGPGMAFTGAGISTESGIPDYRGPNGLWSRENPTRYRDFLNDPE
VRRRYWDRRRQRYPILAGARPNVGHVALARLQAAGYLEIIVTQNIDGLHQKAGSPPERVVELHGTAHAIRCLSCELLWPA
EEFDPGPPGTIPDCPVCGGLVKEATVSFGEPVPRRILEHALALAEATPVMLVIGTSLKVVPAAHVPRRAARAGAFVAIVN
DEPTPLDREAAVVLRARAGAALAYLAELLVGAPADSARERAS

Sequences:

>Translated_282_residues
MGLVGLGTEGEAAVDGGALSAEQRRLVEAIADALYQRGPGMAFTGAGISTESGIPDYRGPNGLWSRENPTRYRDFLNDPE
VRRRYWDRRRQRYPILAGARPNVGHVALARLQAAGYLEIIVTQNIDGLHQKAGSPPERVVELHGTAHAIRCLSCELLWPA
EEFDPGPPGTIPDCPVCGGLVKEATVSFGEPVPRRILEHALALAEATPVMLVIGTSLKVVPAAHVPRRAARAGAFVAIVN
DEPTPLDREAAVVLRARAGAALAYLAELLVGAPADSARERAS
>Mature_281_residues
GLVGLGTEGEAAVDGGALSAEQRRLVEAIADALYQRGPGMAFTGAGISTESGIPDYRGPNGLWSRENPTRYRDFLNDPEV
RRRYWDRRRQRYPILAGARPNVGHVALARLQAAGYLEIIVTQNIDGLHQKAGSPPERVVELHGTAHAIRCLSCELLWPAE
EFDPGPPGTIPDCPVCGGLVKEATVSFGEPVPRRILEHALALAEATPVMLVIGTSLKVVPAAHVPRRAARAGAFVAIVND
EPTPLDREAAVVLRARAGAALAYLAELLVGAPADSARERAS

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=253, Percent_Identity=34.3873517786561, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI63054862, Length=208, Percent_Identity=36.5384615384615, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI6912660, Length=224, Percent_Identity=36.6071428571429, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI300797577, Length=258, Percent_Identity=29.4573643410853, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI300795542, Length=233, Percent_Identity=33.0472103004292, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI300797597, Length=248, Percent_Identity=29.0322580645161, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI6912664, Length=246, Percent_Identity=32.1138211382114, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13787215, Length=229, Percent_Identity=33.6244541484716, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13775602, Length=204, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI13775600, Length=204, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI300797705, Length=190, Percent_Identity=33.1578947368421, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI7657575, Length=248, Percent_Identity=28.6290322580645, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI308199517, Length=243, Percent_Identity=34.5679012345679, Blast_Score=95, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17567771, Length=256, Percent_Identity=33.984375, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71990482, Length=256, Percent_Identity=33.59375, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71990487, Length=258, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17505510, Length=255, Percent_Identity=27.0588235294118, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17541892, Length=195, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325242, Length=234, Percent_Identity=31.6239316239316, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320163, Length=244, Percent_Identity=24.5901639344262, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571445, Length=273, Percent_Identity=34.0659340659341, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24645650, Length=268, Percent_Identity=26.865671641791, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571443, Length=223, Percent_Identity=31.8385650224215, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571441, Length=223, Percent_Identity=31.8385650224215, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648389, Length=200, Percent_Identity=31.5, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17137536, Length=222, Percent_Identity=29.7297297297297, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30065; Mature: 29933

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLVGLGTEGEAAVDGGALSAEQRRLVEAIADALYQRGPGMAFTGAGISTESGIPDYRGP
CCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
NGLWSRENPTRYRDFLNDPEVRRRYWDRRRQRYPILAGARPNVGHVALARLQAAGYLEII
CCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCEEEEE
VTQNIDGLHQKAGSPPERVVELHGTAHAIRCLSCELLWPAEEFDPGPPGTIPDCPVCGGL
EECCCCHHHHHCCCCHHHHHHHCCCHHHHHHHEEEEECCHHHCCCCCCCCCCCCCCHHHH
VKEATVSFGEPVPRRILEHALALAEATPVMLVIGTSLKVVPAAHVPRRAARAGAFVAIVN
HHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCHHHHHCCCEEEEEC
DEPTPLDREAAVVLRARAGAALAYLAELLVGAPADSARERAS
CCCCCCCCHHHEEEHHHCCHHHHHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure 
GLVGLGTEGEAAVDGGALSAEQRRLVEAIADALYQRGPGMAFTGAGISTESGIPDYRGP
CEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
NGLWSRENPTRYRDFLNDPEVRRRYWDRRRQRYPILAGARPNVGHVALARLQAAGYLEII
CCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCEEEEE
VTQNIDGLHQKAGSPPERVVELHGTAHAIRCLSCELLWPAEEFDPGPPGTIPDCPVCGGL
EECCCCHHHHHCCCCHHHHHHHCCCHHHHHHHEEEEECCHHHCCCCCCCCCCCCCCHHHH
VKEATVSFGEPVPRRILEHALALAEATPVMLVIGTSLKVVPAAHVPRRAARAGAFVAIVN
HHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCHHHHHCCCEEEEEC
DEPTPLDREAAVVLRARAGAALAYLAELLVGAPADSARERAS
CCCCCCCCHHHEEEHHHCCHHHHHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA