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The map label for this gene is 221635867

Identifier: 221635867

GI number: 221635867

Start: 448872

End: 450356

Strand: Reverse

Name: 221635867

Synonym: trd_A0461

Alternate gene names: NA

Gene position: 450356-448872 (Counterclockwise)

Preceding gene: 221635868

Following gene: 221635864

Centisome position: 49.07

GC content: 63.37

Gene sequence:

>1485_bases
ATGACGATGCACGAGGAACTCGCCTACATGAGCGCAACCGAACTCGCCCTCCATATCCGCCGACGCCAACTCTCGCCAGT
CGAGGTCGTGGACGCCTTCATCACTCGGATCGAGCAGCGCAACCCCAGTCTTAACGCCTTCGTTTATTTCGGATTCGACG
AGGCTCGCCAGCGCGCTCGCGACGCCGAGCAGGCCGTGCTGCGCGGCGATCCACTCGGCCCGCTCCATGGTGTACCGACC
GCGATCAAAGATCTTTTTGATTTCAAGCCCGGATGGAAGAGCACCTTCGGTGGCATCCGGGCACTCAAAGACCATGTCGT
CAACGCCTATTGCTTGTTCGCCGAGCGGGTCGAGCGTGCGGGTGCTATCGTCCTGGGCAAGACCAATAGCCCAGTCATGG
GTTTCCGTGGAACCTGCGACAATTATCTCTTCGGTCCTTCGCGCAATCCCTTCGATCTTCGGCGCAACACTGGTGGTTCA
TCTGGCGGGAGCGCCGCTGCAGTGGCCGACGGGCTCGTCCCCTTCGCCGAAGGGACCGACGGCGGCGGCTCGATCCGCAT
CCCCGCCGCATGGTGCGGTGTCTACGGCTACAAGGCCTCCTTTGGCCGCGTTCCCTTCGTTGCCCGTCCCAACGCGTTCG
CTGGCGACACACCGTTCCTCTTCGAGGGTCCTATCACGCGCACCGTCGAGGACGCGGCGCTCGTCCTCTCCGCAATCGCC
GGCTACGATCCACGTGATCCCTTTGCGCTCGACGAGCAGGTCGACTTCCTCGCTGCCACACGCCGCTCGATTCACGGTTG
GCGCATCGGCTACAGCCCCAACTTCGATGTCTTCCCAGTCGAGCCGGAGGTAGCAACGGTGGTGAGCCGAGCAGTGCGCG
CCTTCGAGGAAGCGGGTGCCACCGTCGAAGAAGTACGGATCGGAATAACACGCTCTCAGCGAGAACTCAGCGACCTCTGG
TGTCGCCTCATCATGCCGATCAACTTGTTGACGCTCGACGGGTTCGCGGCGCAGGGGATCGACCTTCTCGGCGAGCACCG
CGACGATTTTCCCCCACAATATCTCGAATGGGTCGAGAAGACTCGCTCGATGACCGCCTTGGATTTCTATCGCGACCAGT
GCATCCGCTCGGAGGTCTACGACGCGATCCAGAGCGTCTTCGAACGCTACGATCTCCTCGTTACACCGACCCTGGCCTGC
CTGCCGGTGGAAAACGCCGATGACGGCAACACCGTCGGGCCGAGCCAAGTAAACGGCGAGTCCGTCGACCCGCTGATCGG
CTGGTGTCTCACCTATCCGGTCAACTTCAGCGGGCATCCGGCAGCCTCGATCCCGGCCGGGCTGAGCGCGAGCGGGTTGC
CGGTCGGGTTGCAGATCATCGGGCGGCGCTACGCCGATGCCGACGTTCTGACCGCGAGCGCGGTCTTCGAGCGGGTGCGT
CCCTGGCAGGAACTCTATCAGCGCTGTGCCGCGCGCCCGCTCTGA

Upstream 100 bases:

>100_bases
GATGGCAGTTCCGCAGAACCCGATGATCTCCTGACGCCAACGGATCGAGTCGCGTTGGCGAAACCTGAACGCACCCGTCA
TGGGCGAAAGGAGAGCTGTC

Downstream 100 bases:

>100_bases
GCTCAGCGACGCGATCGACTCATAGTGTCGGTTTTTGGGCTGCAAGCAAAGCGCTCTCCCCTTGGGCGGCTCGACCCGCC
CCCGAGCGCCCGTTGGCGCA

Product: glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADTsubunit A)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTMHEELAYMSATELALHIRRRQLSPVEVVDAFITRIEQRNPSLNAFVYFGFDEARQRARDAEQAVLRGDPLGPLHGVPT
AIKDLFDFKPGWKSTFGGIRALKDHVVNAYCLFAERVERAGAIVLGKTNSPVMGFRGTCDNYLFGPSRNPFDLRRNTGGS
SGGSAAAVADGLVPFAEGTDGGGSIRIPAAWCGVYGYKASFGRVPFVARPNAFAGDTPFLFEGPITRTVEDAALVLSAIA
GYDPRDPFALDEQVDFLAATRRSIHGWRIGYSPNFDVFPVEPEVATVVSRAVRAFEEAGATVEEVRIGITRSQRELSDLW
CRLIMPINLLTLDGFAAQGIDLLGEHRDDFPPQYLEWVEKTRSMTALDFYRDQCIRSEVYDAIQSVFERYDLLVTPTLAC
LPVENADDGNTVGPSQVNGESVDPLIGWCLTYPVNFSGHPAASIPAGLSASGLPVGLQIIGRRYADADVLTASAVFERVR
PWQELYQRCAARPL

Sequences:

>Translated_494_residues
MTMHEELAYMSATELALHIRRRQLSPVEVVDAFITRIEQRNPSLNAFVYFGFDEARQRARDAEQAVLRGDPLGPLHGVPT
AIKDLFDFKPGWKSTFGGIRALKDHVVNAYCLFAERVERAGAIVLGKTNSPVMGFRGTCDNYLFGPSRNPFDLRRNTGGS
SGGSAAAVADGLVPFAEGTDGGGSIRIPAAWCGVYGYKASFGRVPFVARPNAFAGDTPFLFEGPITRTVEDAALVLSAIA
GYDPRDPFALDEQVDFLAATRRSIHGWRIGYSPNFDVFPVEPEVATVVSRAVRAFEEAGATVEEVRIGITRSQRELSDLW
CRLIMPINLLTLDGFAAQGIDLLGEHRDDFPPQYLEWVEKTRSMTALDFYRDQCIRSEVYDAIQSVFERYDLLVTPTLAC
LPVENADDGNTVGPSQVNGESVDPLIGWCLTYPVNFSGHPAASIPAGLSASGLPVGLQIIGRRYADADVLTASAVFERVR
PWQELYQRCAARPL
>Mature_493_residues
TMHEELAYMSATELALHIRRRQLSPVEVVDAFITRIEQRNPSLNAFVYFGFDEARQRARDAEQAVLRGDPLGPLHGVPTA
IKDLFDFKPGWKSTFGGIRALKDHVVNAYCLFAERVERAGAIVLGKTNSPVMGFRGTCDNYLFGPSRNPFDLRRNTGGSS
GGSAAAVADGLVPFAEGTDGGGSIRIPAAWCGVYGYKASFGRVPFVARPNAFAGDTPFLFEGPITRTVEDAALVLSAIAG
YDPRDPFALDEQVDFLAATRRSIHGWRIGYSPNFDVFPVEPEVATVVSRAVRAFEEAGATVEEVRIGITRSQRELSDLWC
RLIMPINLLTLDGFAAQGIDLLGEHRDDFPPQYLEWVEKTRSMTALDFYRDQCIRSEVYDAIQSVFERYDLLVTPTLACL
PVENADDGNTVGPSQVNGESVDPLIGWCLTYPVNFSGHPAASIPAGLSASGLPVGLQIIGRRYADADVLTASAVFERVRP
WQELYQRCAARPL

Specific function: Unknown

COG id: COG0154

COG function: function code J; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amidase family [H]

Homologues:

Organism=Homo sapiens, GI195972892, Length=502, Percent_Identity=27.8884462151394, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI222831590, Length=538, Percent_Identity=27.5092936802974, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI166795287, Length=294, Percent_Identity=30.2721088435374, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17537465, Length=513, Percent_Identity=26.9005847953216, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71990152, Length=229, Percent_Identity=32.7510917030568, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17538252, Length=295, Percent_Identity=29.1525423728814, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17556264, Length=323, Percent_Identity=26.9349845201238, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17543272, Length=470, Percent_Identity=24.2553191489362, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17556276, Length=338, Percent_Identity=24.5562130177515, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17556278, Length=338, Percent_Identity=24.5562130177515, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538254, Length=318, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320448, Length=238, Percent_Identity=28.9915966386555, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323950, Length=432, Percent_Identity=23.3796296296296, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319685, Length=423, Percent_Identity=26.4775413711584, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644968, Length=507, Percent_Identity=27.0216962524655, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24652985, Length=498, Percent_Identity=28.3132530120482, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922090, Length=498, Percent_Identity=28.3132530120482, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652981, Length=498, Percent_Identity=28.3132530120482, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652983, Length=498, Percent_Identity=28.3132530120482, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21356731, Length=493, Percent_Identity=26.369168356998, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24648113, Length=502, Percent_Identity=30.6772908366534, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI45550774, Length=326, Percent_Identity=28.5276073619632, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI161078093, Length=515, Percent_Identity=26.6019417475728, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24648435, Length=326, Percent_Identity=28.5276073619632, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24648437, Length=326, Percent_Identity=28.5276073619632, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24648441, Length=250, Percent_Identity=27.2, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648439, Length=250, Percent_Identity=27.2, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000120
- InterPro:   IPR020556 [H]

Pfam domain/function: PF01425 Amidase [H]

EC number: =3.5.1.4 [H]

Molecular weight: Translated: 54177; Mature: 54046

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00571 AMIDASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMHEELAYMSATELALHIRRRQLSPVEVVDAFITRIEQRNPSLNAFVYFGFDEARQRAR
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHH
DAEQAVLRGDPLGPLHGVPTAIKDLFDFKPGWKSTFGGIRALKDHVVNAYCLFAERVERA
HHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAIVLGKTNSPVMGFRGTCDNYLFGPSRNPFDLRRNTGGSSGGSAAAVADGLVPFAEGTD
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHCCCCCCCCCC
GGGSIRIPAAWCGVYGYKASFGRVPFVARPNAFAGDTPFLFEGPITRTVEDAALVLSAIA
CCCEEEECHHHHHHHCCCCCCCCCCEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHH
GYDPRDPFALDEQVDFLAATRRSIHGWRIGYSPNFDVFPVEPEVATVVSRAVRAFEEAGA
CCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHCC
TVEEVRIGITRSQRELSDLWCRLIMPINLLTLDGFAAQGIDLLGEHRDDFPPQYLEWVEK
CHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHCHHHHHCCCCCCCHHHHHHHHH
TRSMTALDFYRDQCIRSEVYDAIQSVFERYDLLVTPTLACLPVENADDGNTVGPSQVNGE
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
SVDPLIGWCLTYPVNFSGHPAASIPAGLSASGLPVGLQIIGRRYADADVLTASAVFERVR
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHC
PWQELYQRCAARPL
HHHHHHHHHHCCCC
>Mature Secondary Structure 
TMHEELAYMSATELALHIRRRQLSPVEVVDAFITRIEQRNPSLNAFVYFGFDEARQRAR
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHH
DAEQAVLRGDPLGPLHGVPTAIKDLFDFKPGWKSTFGGIRALKDHVVNAYCLFAERVERA
HHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAIVLGKTNSPVMGFRGTCDNYLFGPSRNPFDLRRNTGGSSGGSAAAVADGLVPFAEGTD
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHCCCCCCCCCC
GGGSIRIPAAWCGVYGYKASFGRVPFVARPNAFAGDTPFLFEGPITRTVEDAALVLSAIA
CCCEEEECHHHHHHHCCCCCCCCCCEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHH
GYDPRDPFALDEQVDFLAATRRSIHGWRIGYSPNFDVFPVEPEVATVVSRAVRAFEEAGA
CCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHCC
TVEEVRIGITRSQRELSDLWCRLIMPINLLTLDGFAAQGIDLLGEHRDDFPPQYLEWVEK
CHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHCHHHHHCCCCCCCHHHHHHHHH
TRSMTALDFYRDQCIRSEVYDAIQSVFERYDLLVTPTLACLPVENADDGNTVGPSQVNGE
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
SVDPLIGWCLTYPVNFSGHPAASIPAGLSASGLPVGLQIIGRRYADADVLTASAVFERVR
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHC
PWQELYQRCAARPL
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]