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The map label for this gene is adhB [H]

Identifier: 221635792

GI number: 221635792

Start: 370948

End: 372066

Strand: Reverse

Name: adhB [H]

Synonym: trd_A0386

Alternate gene names: 221635792

Gene position: 372066-370948 (Counterclockwise)

Preceding gene: 221635802

Following gene: 221635791

Centisome position: 40.54

GC content: 63.72

Gene sequence:

>1119_bases
ATGAAGTCCCGCGCCGCGGTCTTGTACGGCCCGACCCGCTCGTTCTCCATCGAGGAGATCGACGTCGACGAGCCGAAAGA
GGGAGAAGTGCTCGTCAAGCTGGTCGCCACTGGACTGTGCCATTCCGATTGGCACTTCGCGACTGGCGCTGCCCCCGTTC
GCTTTCCCATGGTCGTCGGGCACGAAGGTGCTGGCATCGTGGAAAAGGTCGGTCCCGGCGTCAGCGAGGTCCAGCCGGGT
GACCACGTCGTGCTCTGTTACATCCCCGCCTGCGGCAAGTGTCGCTGGTGCCTGAGCGGGCTGGCAGCACTCTGCGATCG
CGGTATCCTTCTGACACAAGGAGCCCAGCTCGATGGGACCTTCCGTTTCCACAAAGACGGGCAAGACATTGCGCAATTCG
CACTCGTCTCGGCCTTCAGCGAGTACACCGTCTGTCCCGTCGATTCGGTGATCAAGATCGATCCCGATCTCCCGCTCGAT
CGCGCCTGCTTGGTCGGCTGTGCGGTGCCCACCGGCTGGGGTGCGGCCGTCAACCGGGCACGCGTGCGACCGGGGGAGAC
GGTGGCCATCTTCGGGACGGGTGGGGTGGGGATGAACGCCGTGCAAGGAGCAGCGCTGGCGGGTGCCGAGAAGGTGATCG
CCATCAATCTGGTGGACTGGAAACTCGAGAAGGCCAAGGAATTCGGCGCGACTCACACGATCAACCCCACCCGCGAGGAT
CCCGTCCAGCGCATCATGGACATCACGCACGGGGTGGGCGCTGATGCCACCATCTTGACCCCGAGCCTGGTGACCCCATC
GCTCCTCACGACTGCGACCCGTGCTACCCGCAAAGCCGGCCGAACCGTCATCGTGGGAGCGATCGGCCGCGACCCCAACG
AGGTGGAAACGCACCCTCTCGACCTCATGTTCATGCTGATGGCGAAGGAGGTCTTCGGCACGATTTTCGGTCATAACGTA
CCGCGCATCGACATCCCACGCTTGCTCGCACTCTACCGGGACGGCAAGCTCAAGCTGGACGAACTCGTCACTCGCCGCTA
CCGGCTCGAGGAGATCAACCAGGCCTATCATGACGTCGAGCGCGGTCAGGTCATCCGCGGCGTGCTCGTCTTCGATTGA

Upstream 100 bases:

>100_bases
TCCTGGCATGTTGGGCAGTCTTGCTCACCGCGCGAGCGTCTGCTATCATCCGCTCGGTCAGCATAGGTTCATCGCTAAAT
CAAGATAAAGGGGGTGTTCG

Downstream 100 bases:

>100_bases
CGAAGCGCGATGTACAGGCTGGTGGAGCGATAGTCCTCCCCACTAGCCTGCTGGCCAGGGTCGCACACCGTCCGGCATCC
GCCACCGACGAGCGAAGATC

Product: alcohol dehydrogenase B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKSRAAVLYGPTRSFSIEEIDVDEPKEGEVLVKLVATGLCHSDWHFATGAAPVRFPMVVGHEGAGIVEKVGPGVSEVQPG
DHVVLCYIPACGKCRWCLSGLAALCDRGILLTQGAQLDGTFRFHKDGQDIAQFALVSAFSEYTVCPVDSVIKIDPDLPLD
RACLVGCAVPTGWGAAVNRARVRPGETVAIFGTGGVGMNAVQGAALAGAEKVIAINLVDWKLEKAKEFGATHTINPTRED
PVQRIMDITHGVGADATILTPSLVTPSLLTTATRATRKAGRTVIVGAIGRDPNEVETHPLDLMFMLMAKEVFGTIFGHNV
PRIDIPRLLALYRDGKLKLDELVTRRYRLEEINQAYHDVERGQVIRGVLVFD

Sequences:

>Translated_372_residues
MKSRAAVLYGPTRSFSIEEIDVDEPKEGEVLVKLVATGLCHSDWHFATGAAPVRFPMVVGHEGAGIVEKVGPGVSEVQPG
DHVVLCYIPACGKCRWCLSGLAALCDRGILLTQGAQLDGTFRFHKDGQDIAQFALVSAFSEYTVCPVDSVIKIDPDLPLD
RACLVGCAVPTGWGAAVNRARVRPGETVAIFGTGGVGMNAVQGAALAGAEKVIAINLVDWKLEKAKEFGATHTINPTRED
PVQRIMDITHGVGADATILTPSLVTPSLLTTATRATRKAGRTVIVGAIGRDPNEVETHPLDLMFMLMAKEVFGTIFGHNV
PRIDIPRLLALYRDGKLKLDELVTRRYRLEEINQAYHDVERGQVIRGVLVFD
>Mature_372_residues
MKSRAAVLYGPTRSFSIEEIDVDEPKEGEVLVKLVATGLCHSDWHFATGAAPVRFPMVVGHEGAGIVEKVGPGVSEVQPG
DHVVLCYIPACGKCRWCLSGLAALCDRGILLTQGAQLDGTFRFHKDGQDIAQFALVSAFSEYTVCPVDSVIKIDPDLPLD
RACLVGCAVPTGWGAAVNRARVRPGETVAIFGTGGVGMNAVQGAALAGAEKVIAINLVDWKLEKAKEFGATHTINPTRED
PVQRIMDITHGVGADATILTPSLVTPSLLTTATRATRKAGRTVIVGAIGRDPNEVETHPLDLMFMLMAKEVFGTIFGHNV
PRIDIPRLLALYRDGKLKLDELVTRRYRLEEINQAYHDVERGQVIRGVLVFD

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=374, Percent_Identity=40.3743315508021, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=38.8739946380697, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI34577061, Length=373, Percent_Identity=38.6058981233244, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=38.0697050938338, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI156523966, Length=374, Percent_Identity=37.4331550802139, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI262073058, Length=373, Percent_Identity=36.1930294906166, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI71743840, Length=373, Percent_Identity=36.1930294906166, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI4501939, Length=366, Percent_Identity=37.431693989071, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI71565152, Length=379, Percent_Identity=37.467018469657, Blast_Score=235, Evalue=5e-62,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=40.2666666666667, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87081918, Length=349, Percent_Identity=31.5186246418338, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1788073, Length=379, Percent_Identity=28.2321899736148, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787863, Length=361, Percent_Identity=26.8698060941828, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082125, Length=382, Percent_Identity=26.1780104712042, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1786825, Length=386, Percent_Identity=27.2020725388601, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788407, Length=352, Percent_Identity=27.2727272727273, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790045, Length=368, Percent_Identity=23.9130434782609, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI226510992, Length=350, Percent_Identity=24.5714285714286, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788075, Length=368, Percent_Identity=24.7282608695652, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786518, Length=368, Percent_Identity=26.3586956521739, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=381, Percent_Identity=37.5328083989501, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI71997431, Length=383, Percent_Identity=37.3368146214099, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17565904, Length=350, Percent_Identity=36.8571428571429, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17562876, Length=379, Percent_Identity=27.1767810026385, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=378, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=374, Percent_Identity=28.6096256684492, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=362, Percent_Identity=27.6243093922652, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=372, Percent_Identity=27.6881720430108, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=383, Percent_Identity=42.2976501305483, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319621, Length=369, Percent_Identity=28.4552845528455, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323729, Length=369, Percent_Identity=27.3712737127371, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=367, Percent_Identity=27.5204359673025, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=356, Percent_Identity=25.2808988764045, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=356, Percent_Identity=25.2808988764045, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=376, Percent_Identity=27.9255319148936, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=366, Percent_Identity=22.9508196721311, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=376, Percent_Identity=38.8297872340425, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17137530, Length=367, Percent_Identity=26.7029972752044, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737897, Length=366, Percent_Identity=26.775956284153, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40112; Mature: 40112

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVLYGPTRSFSIEEIDVDEPKEGEVLVKLVATGLCHSDWHFATGAAPVRFPMVVG
CCCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEC
HEGAGIVEKVGPGVSEVQPGDHVVLCYIPACGKCRWCLSGLAALCDRGILLTQGAQLDGT
CCCCCHHHHHCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCCCE
FRFHKDGQDIAQFALVSAFSEYTVCPVDSVIKIDPDLPLDRACLVGCAVPTGWGAAVNRA
EEECCCCHHHHHHHHHHHHHCCEECCCCCEEEECCCCCCCHHHHEECCCCCCCCHHCCCC
RVRPGETVAIFGTGGVGMNAVQGAALAGAEKVIAINLVDWKLEKAKEFGATHTINPTRED
CCCCCCEEEEEECCCCCCHHHCCHHHCCCCEEEEEEEEHHHHHHHHHCCCCCCCCCCCHH
PVQRIMDITHGVGADATILTPSLVTPSLLTTATRATRKAGRTVIVGAIGRDPNEVETHPL
HHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHH
DLMFMLMAKEVFGTIFGHNVPRIDIPRLLALYRDGKLKLDELVTRRYRLEEINQAYHDVE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RGQVIRGVLVFD
CCCEEEEEEEEC
>Mature Secondary Structure
MKSRAAVLYGPTRSFSIEEIDVDEPKEGEVLVKLVATGLCHSDWHFATGAAPVRFPMVVG
CCCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEC
HEGAGIVEKVGPGVSEVQPGDHVVLCYIPACGKCRWCLSGLAALCDRGILLTQGAQLDGT
CCCCCHHHHHCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCCCE
FRFHKDGQDIAQFALVSAFSEYTVCPVDSVIKIDPDLPLDRACLVGCAVPTGWGAAVNRA
EEECCCCHHHHHHHHHHHHHCCEECCCCCEEEECCCCCCCHHHHEECCCCCCCCHHCCCC
RVRPGETVAIFGTGGVGMNAVQGAALAGAEKVIAINLVDWKLEKAKEFGATHTINPTRED
CCCCCCEEEEEECCCCCCHHHCCHHHCCCCEEEEEEEEHHHHHHHHHCCCCCCCCCCCHH
PVQRIMDITHGVGADATILTPSLVTPSLLTTATRATRKAGRTVIVGAIGRDPNEVETHPL
HHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHH
DLMFMLMAKEVFGTIFGHNVPRIDIPRLLALYRDGKLKLDELVTRRYRLEEINQAYHDVE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RGQVIRGVLVFD
CCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]