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The map label for this gene is zitB [H]

Identifier: 221635607

GI number: 221635607

Start: 183439

End: 184425

Strand: Reverse

Name: zitB [H]

Synonym: trd_A0201

Alternate gene names: 221635607

Gene position: 184425-183439 (Counterclockwise)

Preceding gene: 221635608

Following gene: 221635606

Centisome position: 20.1

GC content: 68.9

Gene sequence:

>987_bases
ATGCACCGGCATGAGCACCAGCACACCCCGGCCAGTCTGCGGGCCGAGTACAAGCAGCGCGCGCTCGCCTGGGCGCTCGG
CATCACGCTGGTCTTCATGGTGGCAGAGGCGATCGGCGGGTGGCTGGCTGGCTCGCTGGCCCTCCTGGCTGATGCCGCCC
ACATGGCGACCGATGCGGCAGCACTCGGACTCGCGCTGTTCGCCAGCCTGCTGGCGCGTCGACCGGCCACGCCGGCGCGC
TCCTACGGCTTCTATCGGGCCGAGGTACTGGCCGCGCTGGCCAATGCCGCCTTCCTCATACTGGTTTGTGCCGGCATCTT
TTGGGAAGCGTTCCAGCGCCTGCTCCATCCTCGGCCGGTCGATGCTCCGCTGATGCTCGCCATCGCGCTGGCTGGGCTGG
CAGCCAATGGCGCAGCAGCGTGGGTTCTCTCGCGCGGCGCGCTGCATCGTCACGACGTCAACCTGCGGAGCGCCTTCCTG
CACGTCCTCGGTGACCTGCTCGGCTCGGTCGCGGCCATCGCCGCCGGCACGATCATCTGGCTGACCGGCTGGACGCCGGT
CGATCCGCTGCTCTCGGCGGCCATCGGGTTGCTCGTCCTGCGCTCCGCCTGGCGTGTGCTCTGGGACTCGGTCGAGGTCC
TGCTGGAAGCCACACCGGCTCACCTCGATCCCGGCGCGATCCGCGCTGCCATGCGCACCGTCCCTGGTGTCGTCGACGTG
CACGATCTCCATGTCTGGACGGTCACCAGCGGCTTCATCGCGCTGAGCGGACACGTCGAAGTGGACGAGACGCGCCCGTG
GCCAGCGGTGCTCCTCGATCTCGCCCAGGTTCTGCGTGACCGCTTCGGGATCCTGCACGTGACGCTCCAACCCGAGGAAC
CGGCTGGGCTCCCGGAAGCATTCCGCGGCTGCTCACTCGATTCACCGGAAGGCTTGCGCAGCTGCCTCTTGCCACTGGCC
GAGGAGACCACCACGAGCCAGCGTTGA

Upstream 100 bases:

>100_bases
CGGGGGAATCCGCAACGAGCAGTCCACCTGGCGGAACTCGCCGCCGAGCGCCTGGCCGATCTCGCAGGCCCGCCAGTGGA
ACAGGGAGAACGCACGATCC

Downstream 100 bases:

>100_bases
CGAGCGCGGTCGACCCGGAACGACAGCCACTGGCGACACGCGTGCAGGCCAGGCCTGCCGGGAAGGCGGCTGCAGGACGA
TCTCTTGCAGGATCCGGTCG

Product: zinc transporter ZitB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MHRHEHQHTPASLRAEYKQRALAWALGITLVFMVAEAIGGWLAGSLALLADAAHMATDAAALGLALFASLLARRPATPAR
SYGFYRAEVLAALANAAFLILVCAGIFWEAFQRLLHPRPVDAPLMLAIALAGLAANGAAAWVLSRGALHRHDVNLRSAFL
HVLGDLLGSVAAIAAGTIIWLTGWTPVDPLLSAAIGLLVLRSAWRVLWDSVEVLLEATPAHLDPGAIRAAMRTVPGVVDV
HDLHVWTVTSGFIALSGHVEVDETRPWPAVLLDLAQVLRDRFGILHVTLQPEEPAGLPEAFRGCSLDSPEGLRSCLLPLA
EETTTSQR

Sequences:

>Translated_328_residues
MHRHEHQHTPASLRAEYKQRALAWALGITLVFMVAEAIGGWLAGSLALLADAAHMATDAAALGLALFASLLARRPATPAR
SYGFYRAEVLAALANAAFLILVCAGIFWEAFQRLLHPRPVDAPLMLAIALAGLAANGAAAWVLSRGALHRHDVNLRSAFL
HVLGDLLGSVAAIAAGTIIWLTGWTPVDPLLSAAIGLLVLRSAWRVLWDSVEVLLEATPAHLDPGAIRAAMRTVPGVVDV
HDLHVWTVTSGFIALSGHVEVDETRPWPAVLLDLAQVLRDRFGILHVTLQPEEPAGLPEAFRGCSLDSPEGLRSCLLPLA
EETTTSQR
>Mature_328_residues
MHRHEHQHTPASLRAEYKQRALAWALGITLVFMVAEAIGGWLAGSLALLADAAHMATDAAALGLALFASLLARRPATPAR
SYGFYRAEVLAALANAAFLILVCAGIFWEAFQRLLHPRPVDAPLMLAIALAGLAANGAAAWVLSRGALHRHDVNLRSAFL
HVLGDLLGSVAAIAAGTIIWLTGWTPVDPLLSAAIGLLVLRSAWRVLWDSVEVLLEATPAHLDPGAIRAAMRTVPGVVDV
HDLHVWTVTSGFIALSGHVEVDETRPWPAVLLDLAQVLRDRFGILHVTLQPEEPAGLPEAFRGCSLDSPEGLRSCLLPLA
EETTTSQR

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21361112, Length=318, Percent_Identity=33.3333333333333, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI52352805, Length=298, Percent_Identity=32.5503355704698, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI21359890, Length=323, Percent_Identity=30.030959752322, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI64762489, Length=286, Percent_Identity=32.5174825174825, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289803013, Length=286, Percent_Identity=32.5174825174825, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289803009, Length=286, Percent_Identity=32.5174825174825, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289803007, Length=286, Percent_Identity=32.5174825174825, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289803003, Length=286, Percent_Identity=32.5174825174825, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI20070323, Length=339, Percent_Identity=27.1386430678466, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI222080086, Length=304, Percent_Identity=26.9736842105263, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI40255009, Length=304, Percent_Identity=26.9736842105263, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI14210520, Length=229, Percent_Identity=28.3842794759825, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI52351208, Length=125, Percent_Identity=41.6, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI52352803, Length=132, Percent_Identity=40.1515151515151, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786966, Length=298, Percent_Identity=45.9731543624161, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1790349, Length=234, Percent_Identity=27.3504273504274, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193210990, Length=314, Percent_Identity=32.484076433121, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17555794, Length=307, Percent_Identity=33.5504885993485, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17555796, Length=303, Percent_Identity=34.3234323432343, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32564488, Length=312, Percent_Identity=28.2051282051282, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17550440, Length=118, Percent_Identity=38.135593220339, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17550442, Length=118, Percent_Identity=38.135593220339, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=192, Percent_Identity=29.6875, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320411, Length=191, Percent_Identity=30.8900523560209, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=159, Percent_Identity=35.8490566037736, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24583858, Length=343, Percent_Identity=26.8221574344023, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24656728, Length=190, Percent_Identity=31.0526315789474, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24656724, Length=190, Percent_Identity=31.0526315789474, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24656720, Length=190, Percent_Identity=31.0526315789474, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24656715, Length=190, Percent_Identity=31.0526315789474, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357035, Length=190, Percent_Identity=31.0526315789474, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24584409, Length=125, Percent_Identity=44, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574430, Length=125, Percent_Identity=44, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585900, Length=151, Percent_Identity=31.1258278145695, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585898, Length=151, Percent_Identity=31.1258278145695, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585896, Length=151, Percent_Identity=31.1258278145695, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921672, Length=151, Percent_Identity=31.1258278145695, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645863, Length=105, Percent_Identity=34.2857142857143, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35091; Mature: 35091

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRHEHQHTPASLRAEYKQRALAWALGITLVFMVAEAIGGWLAGSLALLADAAHMATDAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGLALFASLLARRPATPARSYGFYRAEVLAALANAAFLILVCAGIFWEAFQRLLHPRPV
HHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAPLMLAIALAGLAANGAAAWVLSRGALHRHDVNLRSAFLHVLGDLLGSVAAIAAGTIIW
CHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
LTGWTPVDPLLSAAIGLLVLRSAWRVLWDSVEVLLEATPAHLDPGAIRAAMRTVPGVVDV
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEE
HDLHVWTVTSGFIALSGHVEVDETRPWPAVLLDLAQVLRDRFGILHVTLQPEEPAGLPEA
EHEEEEEEECCEEEEECCEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHH
FRGCSLDSPEGLRSCLLPLAEETTTSQR
HHCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHRHEHQHTPASLRAEYKQRALAWALGITLVFMVAEAIGGWLAGSLALLADAAHMATDAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGLALFASLLARRPATPARSYGFYRAEVLAALANAAFLILVCAGIFWEAFQRLLHPRPV
HHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAPLMLAIALAGLAANGAAAWVLSRGALHRHDVNLRSAFLHVLGDLLGSVAAIAAGTIIW
CHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
LTGWTPVDPLLSAAIGLLVLRSAWRVLWDSVEVLLEATPAHLDPGAIRAAMRTVPGVVDV
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEE
HDLHVWTVTSGFIALSGHVEVDETRPWPAVLLDLAQVLRDRFGILHVTLQPEEPAGLPEA
EHEEEEEEECCEEEEECCEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHH
FRGCSLDSPEGLRSCLLPLAEETTTSQR
HHCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]