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The map label for this gene is htrA [H]

Identifier: 221635523

GI number: 221635523

Start: 113862

End: 114668

Strand: Reverse

Name: htrA [H]

Synonym: trd_A0117

Alternate gene names: 221635523

Gene position: 114668-113862 (Counterclockwise)

Preceding gene: 221635524

Following gene: 221635522

Centisome position: 12.49

GC content: 70.76

Gene sequence:

>807_bases
ATGGGGCGAGCCAACTCGCTGCTGCTCGTCGCAGTGTTGTTCGCTGGACTCCTGACGCTGGCGCTGGCTGGGCTGGCCGT
CGCCCGCTGGCGGGCACCGGTCGACGTCCCGGCGCTCGACACGCGGGTGGTGCTCACGGTCACGCCGATCCCGACTGTCC
CGCCACTCACCCCTGCACCGACTGCCCCCGCGCCGACACCGGTCGCGAGCGGCCCAGCTGACCCGGGGGACCGGGCGACG
ATGGTGAACCGCGCGCTCCACGGTGTCCTCCAGGTACGGGTGCCGGACGGCTTGGGAACCGGTTTCGTTTGGGCACGCGA
GAGCGACCGGACGCTCGTCGTCACGGCTGCGCACGTCGTTGCCGGCTGGGAACGTGTCGAGGTGATCGCACCTGATGGGA
CGGCACACCCAGCGACCGTGCGCCAGCGTGACGAGCGCCACGACGTCGCGCTGCTCGAGGCGCCGGCGCTGGTCGGTGTC
CAGCCCCTGCCGCGCGGCCAGTCGCGCCAGCTCCCGCTCGGGAGCGCCCTCACGGCGCTCGGCTACGCACTGGGTGACCA
GCTGCTGGGCGAGCCGACAGTCACGCGTGGTGTGCTCTCTGGACGGCGTACCTTCGATGGCATAGAGTTCCTGCAGACCG
ACGCAGCCCTGAATCCCGGTGTGAGTGGCGGCCCGCTGCTCGACGAGCAGGGCAGAGTCGTCGGGATGGCTATCGGGGGG
ATCCCCTGGGCTGGCGAGATCCCCGCGCAGGGTGTCAACTTTGCGGTCGCGATCGAGGAGATCGAGCAGGTTGTGGCGAT
GGCGTAA

Upstream 100 bases:

>100_bases
GAACGCCTACGAACGAGGGCTCCAAGCGGCGCGACGCTTGGACCAGTTGTTCGCCCAGCGCGACCAGCTGCTGGCGCAGC
TCGGCTTCTAGGAGGCAGGC

Downstream 100 bases:

>100_bases
GCGAAGGAGCCATTGATGAGCAAAGAGCACTCACTCCCTTCCGTCCGCCTCCCTCTCGAGACGTTGACGCCACTCTTCCT
CGGCGGCGCTGACCCGCGCG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MGRANSLLLVAVLFAGLLTLALAGLAVARWRAPVDVPALDTRVVLTVTPIPTVPPLTPAPTAPAPTPVASGPADPGDRAT
MVNRALHGVLQVRVPDGLGTGFVWARESDRTLVVTAAHVVAGWERVEVIAPDGTAHPATVRQRDERHDVALLEAPALVGV
QPLPRGQSRQLPLGSALTALGYALGDQLLGEPTVTRGVLSGRRTFDGIEFLQTDAALNPGVSGGPLLDEQGRVVGMAIGG
IPWAGEIPAQGVNFAVAIEEIEQVVAMA

Sequences:

>Translated_268_residues
MGRANSLLLVAVLFAGLLTLALAGLAVARWRAPVDVPALDTRVVLTVTPIPTVPPLTPAPTAPAPTPVASGPADPGDRAT
MVNRALHGVLQVRVPDGLGTGFVWARESDRTLVVTAAHVVAGWERVEVIAPDGTAHPATVRQRDERHDVALLEAPALVGV
QPLPRGQSRQLPLGSALTALGYALGDQLLGEPTVTRGVLSGRRTFDGIEFLQTDAALNPGVSGGPLLDEQGRVVGMAIGG
IPWAGEIPAQGVNFAVAIEEIEQVVAMA
>Mature_267_residues
GRANSLLLVAVLFAGLLTLALAGLAVARWRAPVDVPALDTRVVLTVTPIPTVPPLTPAPTAPAPTPVASGPADPGDRATM
VNRALHGVLQVRVPDGLGTGFVWARESDRTLVVTAAHVVAGWERVEVIAPDGTAHPATVRQRDERHDVALLEAPALVGVQ
PLPRGQSRQLPLGSALTALGYALGDQLLGEPTVTRGVLSGRRTFDGIEFLQTDAALNPGVSGGPLLDEQGRVVGMAIGGI
PWAGEIPAQGVNFAVAIEEIEQVVAMA

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=181, Percent_Identity=31.4917127071823, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI24308541, Length=191, Percent_Identity=28.2722513089005, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI22129776, Length=196, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786356, Length=165, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789630, Length=224, Percent_Identity=29.0178571428571, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789629, Length=167, Percent_Identity=30.5389221556886, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 27697; Mature: 27566

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRANSLLLVAVLFAGLLTLALAGLAVARWRAPVDVPALDTRVVLTVTPIPTVPPLTPAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
TAPAPTPVASGPADPGDRATMVNRALHGVLQVRVPDGLGTGFVWARESDRTLVVTAAHVV
CCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCCEEEEECCCCEEEEEHHHHH
AGWERVEVIAPDGTAHPATVRQRDERHDVALLEAPALVGVQPLPRGQSRQLPLGSALTAL
CCCEEEEEECCCCCCCCHHHHHCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCHHHHHHH
GYALGDQLLGEPTVTRGVLSGRRTFDGIEFLQTDAALNPGVSGGPLLDEQGRVVGMAIGG
HHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECC
IPWAGEIPAQGVNFAVAIEEIEQVVAMA
CCCCCCCCCCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure 
GRANSLLLVAVLFAGLLTLALAGLAVARWRAPVDVPALDTRVVLTVTPIPTVPPLTPAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
TAPAPTPVASGPADPGDRATMVNRALHGVLQVRVPDGLGTGFVWARESDRTLVVTAAHVV
CCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCCEEEEECCCCEEEEEHHHHH
AGWERVEVIAPDGTAHPATVRQRDERHDVALLEAPALVGVQPLPRGQSRQLPLGSALTAL
CCCEEEEEECCCCCCCCHHHHHCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCHHHHHHH
GYALGDQLLGEPTVTRGVLSGRRTFDGIEFLQTDAALNPGVSGGPLLDEQGRVVGMAIGG
HHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECC
IPWAGEIPAQGVNFAVAIEEIEQVVAMA
CCCCCCCCCCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]