Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 221633935

GI number: 221633935

Start: 1981854

End: 1982735

Strand: Reverse

Name: comEC [H]

Synonym: trd_1963

Alternate gene names: 221633935

Gene position: 1982735-1981854 (Counterclockwise)

Preceding gene: 221633936

Following gene: 221633934

Centisome position: 98.99

GC content: 65.08

Gene sequence:

>882_bases
ATGCGCCGGATCATGCTGCTCCTTCTGCTTCTTGGGATCCTGACCGGCTGCCTGCCAGTCGGTCGTTCCCCTGCTGGCCC
GACCAGCGAGATGACGCTGGCCGTTCTCGATGTCGGCCAGGGGCTAGCGGTCGCCATCGTGACGCCTGACGGACACGCCC
TGGTGTACGATGCGGGGAACAGTCGCCAGGACGCTGAACGGGTGATCATCCCGTTCCTGCGCGCTCGTGGTATCGAGCGT
CTCGACTACGCGGTCCTGAGCCATCCGGATCAGGACCATGTCGGTGGCATGCCGGCGCTCCTGGCGAACTTTCCCGTCGC
TGCCTACGTCGATCCGGTCCTGCCCTCGACCAATCGTGCGTATGCCGAGACATTGCGCCTCGTCGCCGAAAAGGGGATAC
GCCCCATTCGGGCGGAACGCGGCCTGGTCCTGCCGCTCGGCGAGCAGGTCACTGCTCGCGTCCTCTGGCCCGAGCGCCCG
TTCCTGCGAGCGCCAGACGGTACCGTGAGCGACAACGATAACTGTGTGGTGCTGCTCGTCGAGTACGGCGCCATGCGCAT
CCTGCTGCCTGGTGACCTCGAGGAGCGAGGAGAAGCCGAGCTCGTCACGCGCGACGGTGAAGGGCTCCATGCGGATATTC
TGGTCGTCGGCCATCATGGCAGCCGAACGTCGTCGAGCGAACCGTTCCTCGCCGCGGTGCGGCCAGCTGTCGCTCTCATC
TCGGTGGGAGCAGGAAATCCGTACGGACATCCCCATCGGGTAACACTCGACCGGCTGCGACGAGCTGGTGCCCAGATTTA
CCGGACCGATCGCGACGGCAGCGTCCTGGTCGTCACGGATGGGAAGCAGTACGAGATCCGGACAGAGAGGACACGATCAT
GA

Upstream 100 bases:

>100_bases
AGCGACCGATCTGGGCGCTCTGGCTCCTGGCCGTGGCGACCAACCTGACGGTGCTCCAGCGGCTCTGGCTGGTCCGACGC
GCCTCTGGAGCATGAGTCTC

Downstream 100 bases:

>100_bases
CCGCCCTGCGACTCTGGGCGACAGTCGACCGCTTCGAGATGACCGAAGAAGGGCAGGAACTCGCTGTGCTGGTCTTCGAC
GATGGGCAGCAACTCGTCGT

Product: ComE operon protein 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MRRIMLLLLLLGILTGCLPVGRSPAGPTSEMTLAVLDVGQGLAVAIVTPDGHALVYDAGNSRQDAERVIIPFLRARGIER
LDYAVLSHPDQDHVGGMPALLANFPVAAYVDPVLPSTNRAYAETLRLVAEKGIRPIRAERGLVLPLGEQVTARVLWPERP
FLRAPDGTVSDNDNCVVLLVEYGAMRILLPGDLEERGEAELVTRDGEGLHADILVVGHHGSRTSSSEPFLAAVRPAVALI
SVGAGNPYGHPHRVTLDRLRRAGAQIYRTDRDGSVLVVTDGKQYEIRTERTRS

Sequences:

>Translated_293_residues
MRRIMLLLLLLGILTGCLPVGRSPAGPTSEMTLAVLDVGQGLAVAIVTPDGHALVYDAGNSRQDAERVIIPFLRARGIER
LDYAVLSHPDQDHVGGMPALLANFPVAAYVDPVLPSTNRAYAETLRLVAEKGIRPIRAERGLVLPLGEQVTARVLWPERP
FLRAPDGTVSDNDNCVVLLVEYGAMRILLPGDLEERGEAELVTRDGEGLHADILVVGHHGSRTSSSEPFLAAVRPAVALI
SVGAGNPYGHPHRVTLDRLRRAGAQIYRTDRDGSVLVVTDGKQYEIRTERTRS
>Mature_293_residues
MRRIMLLLLLLGILTGCLPVGRSPAGPTSEMTLAVLDVGQGLAVAIVTPDGHALVYDAGNSRQDAERVIIPFLRARGIER
LDYAVLSHPDQDHVGGMPALLANFPVAAYVDPVLPSTNRAYAETLRLVAEKGIRPIRAERGLVLPLGEQVTARVLWPERP
FLRAPDGTVSDNDNCVVLLVEYGAMRILLPGDLEERGEAELVTRDGEGLHADILVVGHHGSRTSSSEPFLAAVRPAVALI
SVGAGNPYGHPHRVTLDRLRRAGAQIYRTDRDGSVLVVTDGKQYEIRTERTRS

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 31715; Mature: 31715

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIMLLLLLLGILTGCLPVGRSPAGPTSEMTLAVLDVGQGLAVAIVTPDGHALVYDAGN
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCEEEEECCC
SRQDAERVIIPFLRARGIERLDYAVLSHPDQDHVGGMPALLANFPVAAYVDPVLPSTNRA
CCCCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHCCCCHHHHHCCCHHHHCCCCCCCCCHH
YAETLRLVAEKGIRPIRAERGLVLPLGEQVTARVLWPERPFLRAPDGTVSDNDNCVVLLV
HHHHHHHHHHHCCCCCHHCCCEEEECCCCEEEEEECCCCCCEECCCCCCCCCCCEEEEEE
EYGAMRILLPGDLEERGEAELVTRDGEGLHADILVVGHHGSRTSSSEPFLAAVRPAVALI
ECCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHHCEEEEE
SVGAGNPYGHPHRVTLDRLRRAGAQIYRTDRDGSVLVVTDGKQYEIRTERTRS
EECCCCCCCCCCCCHHHHHHHCCCEEEEECCCCEEEEEECCCEEEEECCCCCC
>Mature Secondary Structure
MRRIMLLLLLLGILTGCLPVGRSPAGPTSEMTLAVLDVGQGLAVAIVTPDGHALVYDAGN
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCEEEEECCC
SRQDAERVIIPFLRARGIERLDYAVLSHPDQDHVGGMPALLANFPVAAYVDPVLPSTNRA
CCCCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHCCCCHHHHHCCCHHHHCCCCCCCCCHH
YAETLRLVAEKGIRPIRAERGLVLPLGEQVTARVLWPERPFLRAPDGTVSDNDNCVVLLV
HHHHHHHHHHHCCCCCHHCCCEEEECCCCEEEEEECCCCCCEECCCCCCCCCCCEEEEEE
EYGAMRILLPGDLEERGEAELVTRDGEGLHADILVVGHHGSRTSSSEPFLAAVRPAVALI
ECCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHHCEEEEE
SVGAGNPYGHPHRVTLDRLRRAGAQIYRTDRDGSVLVVTDGKQYEIRTERTRS
EECCCCCCCCCCCCHHHHHHHCCCEEEEECCCCEEEEEECCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]