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The map label for this gene is ffh [H]

Identifier: 221633791

GI number: 221633791

Start: 1826614

End: 1828080

Strand: Reverse

Name: ffh [H]

Synonym: trd_1818

Alternate gene names: 221633791

Gene position: 1828080-1826614 (Counterclockwise)

Preceding gene: 221633792

Following gene: 221633790

Centisome position: 91.27

GC content: 63.12

Gene sequence:

>1467_bases
ATGTTCGAGGCGCTGACGGACCGCTTGACCCAGGTCTTCCAACGCATCGGTCGCAAGGGGCGCCTCACCGAAGAGGACGT
CGACGAGGCACTACGTGAAGTCCGACGTGCTCTTTTGGAAGCCGACGTCCATTACACGGTCGTGCGTGACTTCATCGCCG
CGGTCCGCGAGCGCGCGATCGGCGAAGAGGTGCTGCGCTCCTTGACGCCAGCGCAGCAAGTGATCGCCATCGTCCACCAG
GAGCTCGTGCGCGTGCTCGGCAGCGAGCGGGTTCCACTCCTGTGGGCGAGCCAGCCGCCGACGATCATCATGCTGGTCGG
CCTGCAGGGTTCGGGCAAAACAACGCAAGTCGCGAAGCTCGGCTATCACCTGCGCAAGGAGGGACGCCGACCACTGCTCG
TAGCGGCCGATATTTACCGGCCGGCTGCGGTCGAGCAGTTGCGGACGCTGGGCAAGCAGCACGATCTTCCCGTCTACGAC
GAAGGGACCAAGGTTGATCCAGTCGAGACCGTCAAGCATGCGGTCAAGGTCGCCCGCGACCAGGGCTATAACCCGGTTAT
CATCGATACAGCTGGTCGGTTGCAGATCGACGAGCCGATGATGCAGGAACTCGAGCGGATGGCCGAAGCAGTCCGCCCGA
CCGAGATCCTGCTCGTCGCCGACGCCATGACCGGGCAAGAGGCAGTCAATGTCGCCAAAGAGTTTCACCGGCGTCTTTCG
CTGACCGGCCTCATCCTGACCAAGCTGGACGGCGACGCGCGCGGTGGAGCTGCGCTCTCTATTCGAGCCGTGGTCGGGGT
TCCCATCAAATTCATCGGAACCGGTGAGCGGGTCGATGCGCTCGAACCCTTTTATCCTGATCGGCTGGCGACCCGCATCC
TGGGGATGGGCGATGTCCTCTCGCTGATCGAAAAAGCGCAGCAGCAGATCAGCCAGGAAGAGGGGAAGAAACTCCAAGAA
AAACTGCTCGCGGGCACCTTCGATCTGGAAGACTTCCTGCGGCAGTTGCAACAGGTCAAGAAGATGGGTCCGCTCACCCA
GCTCCTGGAGATGATCCCCGGTATGGGGCAGCTGCTGCGCCAGCAGCAGGTGCAGATCAGCGACGACGAGTACAAGCGGA
TCGAGGCGATCATCCTTTCGATGACCCCCGAGGAGCGGCGCAACCCGGACATCATCAACTACAGTCGGCGCCGACGCATC
GCGCAGGGGAGCGGCACGACGATCGCTGAGGTCTCGCAGCTGTTGACGCAGTTCAAGCAGATGCAGCGCATGATGGCCGA
ACTCGGACAGCTGGCTGCTGGACGCAGCCGAGGCCCGCTGCGCGGTCTGCTCGGAGCCGGCAACGCATTCCCGAGCTTGC
CGGGGCTGGACGGTTTCCCAGGGATCGGCACTGCCCCAGCTCGACCGCAGCCAGCAGCCCACCACGGTCGACACCAGAGC
AAGAAGAAAAAGAAGAAGCGCCGCTGA

Upstream 100 bases:

>100_bases
TCGCCTACGTAGGGACTGGTGAGAAGCCAACGGACTTTGCCGAATTCGATCCGGAAGCCTACGTCGACGCCCTGTTCTTC
GGGGACGAGGAGGACTGACC

Downstream 100 bases:

>100_bases
GCGGCACGAGGACCACCACTGACCATGACAACACGAATTGCGACGATCACTGGCTATCTCGTTCGGTCGCTCGCTCATCT
TCCCATCTTTTACAAGGTCT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MFEALTDRLTQVFQRIGRKGRLTEEDVDEALREVRRALLEADVHYTVVRDFIAAVRERAIGEEVLRSLTPAQQVIAIVHQ
ELVRVLGSERVPLLWASQPPTIIMLVGLQGSGKTTQVAKLGYHLRKEGRRPLLVAADIYRPAAVEQLRTLGKQHDLPVYD
EGTKVDPVETVKHAVKVARDQGYNPVIIDTAGRLQIDEPMMQELERMAEAVRPTEILLVADAMTGQEAVNVAKEFHRRLS
LTGLILTKLDGDARGGAALSIRAVVGVPIKFIGTGERVDALEPFYPDRLATRILGMGDVLSLIEKAQQQISQEEGKKLQE
KLLAGTFDLEDFLRQLQQVKKMGPLTQLLEMIPGMGQLLRQQQVQISDDEYKRIEAIILSMTPEERRNPDIINYSRRRRI
AQGSGTTIAEVSQLLTQFKQMQRMMAELGQLAAGRSRGPLRGLLGAGNAFPSLPGLDGFPGIGTAPARPQPAAHHGRHQS
KKKKKKRR

Sequences:

>Translated_488_residues
MFEALTDRLTQVFQRIGRKGRLTEEDVDEALREVRRALLEADVHYTVVRDFIAAVRERAIGEEVLRSLTPAQQVIAIVHQ
ELVRVLGSERVPLLWASQPPTIIMLVGLQGSGKTTQVAKLGYHLRKEGRRPLLVAADIYRPAAVEQLRTLGKQHDLPVYD
EGTKVDPVETVKHAVKVARDQGYNPVIIDTAGRLQIDEPMMQELERMAEAVRPTEILLVADAMTGQEAVNVAKEFHRRLS
LTGLILTKLDGDARGGAALSIRAVVGVPIKFIGTGERVDALEPFYPDRLATRILGMGDVLSLIEKAQQQISQEEGKKLQE
KLLAGTFDLEDFLRQLQQVKKMGPLTQLLEMIPGMGQLLRQQQVQISDDEYKRIEAIILSMTPEERRNPDIINYSRRRRI
AQGSGTTIAEVSQLLTQFKQMQRMMAELGQLAAGRSRGPLRGLLGAGNAFPSLPGLDGFPGIGTAPARPQPAAHHGRHQS
KKKKKKRR
>Mature_488_residues
MFEALTDRLTQVFQRIGRKGRLTEEDVDEALREVRRALLEADVHYTVVRDFIAAVRERAIGEEVLRSLTPAQQVIAIVHQ
ELVRVLGSERVPLLWASQPPTIIMLVGLQGSGKTTQVAKLGYHLRKEGRRPLLVAADIYRPAAVEQLRTLGKQHDLPVYD
EGTKVDPVETVKHAVKVARDQGYNPVIIDTAGRLQIDEPMMQELERMAEAVRPTEILLVADAMTGQEAVNVAKEFHRRLS
LTGLILTKLDGDARGGAALSIRAVVGVPIKFIGTGERVDALEPFYPDRLATRILGMGDVLSLIEKAQQQISQEEGKKLQE
KLLAGTFDLEDFLRQLQQVKKMGPLTQLLEMIPGMGQLLRQQQVQISDDEYKRIEAIILSMTPEERRNPDIINYSRRRRI
AQGSGTTIAEVSQLLTQFKQMQRMMAELGQLAAGRSRGPLRGLLGAGNAFPSLPGLDGFPGIGTAPARPQPAAHHGRHQS
KKKKKKRR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=432, Percent_Identity=34.2592592592593, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI226371618, Length=378, Percent_Identity=35.1851851851852, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI23308697, Length=292, Percent_Identity=29.4520547945205, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI295424842, Length=292, Percent_Identity=29.4520547945205, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI89061728, Length=163, Percent_Identity=37.4233128834356, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=51.7647058823529, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=35.2272727272727, Blast_Score=169, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17539958, Length=423, Percent_Identity=31.9148936170213, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI193206261, Length=291, Percent_Identity=30.5841924398625, Blast_Score=124, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6325345, Length=454, Percent_Identity=34.3612334801762, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6320498, Length=206, Percent_Identity=29.6116504854369, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17647949, Length=428, Percent_Identity=33.411214953271, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24641198, Length=299, Percent_Identity=29.0969899665552, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 54299; Mature: 54299

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS50191 CRAL_TRIO ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEALTDRLTQVFQRIGRKGRLTEEDVDEALREVRRALLEADVHYTVVRDFIAAVRERAI
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVLRSLTPAQQVIAIVHQELVRVLGSERVPLLWASQPPTIIMLVGLQGSGKTTQVAKL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEEECCCCCCHHHHHH
GYHLRKEGRRPLLVAADIYRPAAVEQLRTLGKQHDLPVYDEGTKVDPVETVKHAVKVARD
HHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
QGYNPVIIDTAGRLQIDEPMMQELERMAEAVRPTEILLVADAMTGQEAVNVAKEFHRRLS
CCCCCEEEECCCCCEECHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
LTGLILTKLDGDARGGAALSIRAVVGVPIKFIGTGERVDALEPFYPDRLATRILGMGDVL
HHHHEEEECCCCCCCCCEEEEEEHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHCHHHHH
SLIEKAQQQISQEEGKKLQEKLLAGTFDLEDFLRQLQQVKKMGPLTQLLEMIPGMGQLLR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHH
QQQVQISDDEYKRIEAIILSMTPEERRNPDIINYSRRRRIAQGSGTTIAEVSQLLTQFKQ
HHCCCCCCHHHHHHHHHHEECCCHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
MQRMMAELGQLAAGRSRGPLRGLLGAGNAFPSLPGLDGFPGIGTAPARPQPAAHHGRHQS
HHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHH
KKKKKKRR
HHHHHCCC
>Mature Secondary Structure
MFEALTDRLTQVFQRIGRKGRLTEEDVDEALREVRRALLEADVHYTVVRDFIAAVRERAI
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVLRSLTPAQQVIAIVHQELVRVLGSERVPLLWASQPPTIIMLVGLQGSGKTTQVAKL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEEECCCCCCHHHHHH
GYHLRKEGRRPLLVAADIYRPAAVEQLRTLGKQHDLPVYDEGTKVDPVETVKHAVKVARD
HHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
QGYNPVIIDTAGRLQIDEPMMQELERMAEAVRPTEILLVADAMTGQEAVNVAKEFHRRLS
CCCCCEEEECCCCCEECHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
LTGLILTKLDGDARGGAALSIRAVVGVPIKFIGTGERVDALEPFYPDRLATRILGMGDVL
HHHHEEEECCCCCCCCCEEEEEEHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHCHHHHH
SLIEKAQQQISQEEGKKLQEKLLAGTFDLEDFLRQLQQVKKMGPLTQLLEMIPGMGQLLR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHH
QQQVQISDDEYKRIEAIILSMTPEERRNPDIINYSRRRRIAQGSGTTIAEVSQLLTQFKQ
HHCCCCCCHHHHHHHHHHEECCCHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
MQRMMAELGQLAAGRSRGPLRGLLGAGNAFPSLPGLDGFPGIGTAPARPQPAAHHGRHQS
HHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHH
KKKKKKRR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]