Click here to switch to the map view.

The map label for this gene is dtd

Identifier: 221633695

GI number: 221633695

Start: 1727963

End: 1728427

Strand: Reverse

Name: dtd

Synonym: trd_1722

Alternate gene names: 221633695

Gene position: 1728427-1727963 (Counterclockwise)

Preceding gene: 221633696

Following gene: 221633694

Centisome position: 86.29

GC content: 64.73

Gene sequence:

>465_bases
GTGCGGGTTCTCCTCCAGCGGGTGAGCGAAGCCAGTGTCACGGTTGATGGAACGTTGGTGAGTTCGATCGGCCAGGGAGT
CCTGCTCTTGGTCGGAGTGCGGCATGGTGACGACCGGGCGACGGCCGAGTGGCTCGCGCACAAAGTCGCGCACTTGCGGA
TCTTCGAGGACGAAGCCGGCAAAATGAACCGCTCGCTCCTCGACGTCGGTGGCAGTGCGCTGGTCGTCTCGCAGTTCACA
CTCTATGCCGATGTGCGCAAAGGACGTCGGCCGAGCTTCATCGAGGCTGCCCCGCCGAACGAGGCGCGACCGCTCGTCGA
TACCTTCGCGGAGACGCTGCGGGCACTCGGTGTACCCGTCGAGACCGGTGTGTTCGGTGCGCACATGGACGTCGCGCTCG
TCAACGATGGGCCGGTCACGATCTGGCTGGACAGTGCGGAACTCCGTGGAGGCTCCCTCGATTAG

Upstream 100 bases:

>100_bases
GGTTCATCGGGCGTGGTGAGGGGATCGCTGCGCTGGCCGTGGCGATGCTCCAGCGCAGCGACGAGGAACACGACTCCGAT
CCGGACGGGAGGTAAGGACA

Downstream 100 bases:

>100_bases
GACTTCTGGGGCTCTTGTCGATCGGTATCCAGTGTTACACTCGCTCCTGGAGGATCGAGTACGAACGGAGAAGCTTCGGT
GTACTGCCCGCAGTGTGGAC

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MRVLLQRVSEASVTVDGTLVSSIGQGVLLLVGVRHGDDRATAEWLAHKVAHLRIFEDEAGKMNRSLLDVGGSALVVSQFT
LYADVRKGRRPSFIEAAPPNEARPLVDTFAETLRALGVPVETGVFGAHMDVALVNDGPVTIWLDSAELRGGSLD

Sequences:

>Translated_154_residues
MRVLLQRVSEASVTVDGTLVSSIGQGVLLLVGVRHGDDRATAEWLAHKVAHLRIFEDEAGKMNRSLLDVGGSALVVSQFT
LYADVRKGRRPSFIEAAPPNEARPLVDTFAETLRALGVPVETGVFGAHMDVALVNDGPVTIWLDSAELRGGSLD
>Mature_154_residues
MRVLLQRVSEASVTVDGTLVSSIGQGVLLLVGVRHGDDRATAEWLAHKVAHLRIFEDEAGKMNRSLLDVGGSALVVSQFT
LYADVRKGRRPSFIEAAPPNEARPLVDTFAETLRALGVPVETGVFGAHMDVALVNDGPVTIWLDSAELRGGSLD

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=148, Percent_Identity=43.2432432432432, Blast_Score=117, Evalue=4e-27,
Organism=Escherichia coli, GI1790320, Length=143, Percent_Identity=51.0489510489511, Blast_Score=142, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI115533292, Length=150, Percent_Identity=39.3333333333333, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=45.2702702702703, Blast_Score=118, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281361569, Length=151, Percent_Identity=42.3841059602649, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_THERP (B9L111)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002522921.1
- GeneID:   7356118
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_1722
- OMA:   MKAVIQR
- ProtClustDB:   CLSK2808146
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16486; Mature: 16486

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLQRVSEASVTVDGTLVSSIGQGVLLLVGVRHGDDRATAEWLAHKVAHLRIFEDEAG
CHHHHHHHCCCCEEECHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHEEEECCCCC
KMNRSLLDVGGSALVVSQFTLYADVRKGRRPSFIEAAPPNEARPLVDTFAETLRALGVPV
HHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCC
ETGVFGAHMDVALVNDGPVTIWLDSAELRGGSLD
CCCEEECCEEEEEECCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MRVLLQRVSEASVTVDGTLVSSIGQGVLLLVGVRHGDDRATAEWLAHKVAHLRIFEDEAG
CHHHHHHHCCCCEEECHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHEEEECCCCC
KMNRSLLDVGGSALVVSQFTLYADVRKGRRPSFIEAAPPNEARPLVDTFAETLRALGVPV
HHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCC
ETGVFGAHMDVALVNDGPVTIWLDSAELRGGSLD
CCCEEECCEEEEEECCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA